Prognostic factors of hydrops fetalis with pleural effusion

Atsushi Nakayama, Makoto Oshiro, Yasumasa Yamada, Tetsuo Hattori, Yasuhiro Wakano, Seiji Hayashi, Minoru Kokubo, Koji Takemoto, Shigeru Honda, Kuniko Ieda, Hikaru Yamamoto, Masanori Kouwaki, Kyoko Yokoi, Osamu Shinohara, Takenori Kato, Masafumi Miyata, Taihei Tanaka, Masahiro Hayakawa

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Background: Hydrops fetalis (HF) has a low survival rate, particularly in the case of preterm birth. In addition, the severity index of HF has not been fully investigated yet. The aim of this study was to clarify the prognostic factors of HF with pleural effusion. Methods: All live-born HF patients with pleural effusion, except for chromosomal abnormality or complex congenital heart disease, born from 2009 to 2013 in Aichi Prefecture in Japan were included. Prenatal, perinatal, and postnatal information was obtained from the medical records and was retrospectively analyzed. Results: Forty-one HF patients with pleural effusion were included, and 28 patients (68%) survived. On multivariate logistic stepwise analysis, gestational birth week (OR, 0.71; 95% CI: 0.52–0.96, P = 0.027) and standard deviation (SD) score of the birthweight (OR, 1.74; 95% CI: 1.01–2.99, P = 0.045) were significant factors for postnatal death. All patients with both ≥32 gestational weeks and <3.0 birthweight SD score survived. Conclusions: Combined with the gestational weeks data, birthweight SD score may be useful to estimate the prognosis of HF with pleural effusion.

Original languageEnglish
Pages (from-to)1053-1057
Number of pages5
JournalPediatrics International
Issue number10
Publication statusPublished - 10-2017

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health


Dive into the research topics of 'Prognostic factors of hydrops fetalis with pleural effusion'. Together they form a unique fingerprint.

Cite this