TY - JOUR
T1 - Prognostic impact of C-reactive protein-albumin ratio for the lethality in castration-resistant prostate cancer
AU - Uchimoto, Taizo
AU - Komura, Kazumasa
AU - Fujiwara, Yuya
AU - Saito, Kenkichi
AU - Tanda, Naoki
AU - Matsunaga, Tomohisa
AU - Ichihashi, Atsushi
AU - Tsutsumi, Takeshi
AU - Tsujino, Takuya
AU - Yoshikawa, Yuki
AU - Nishimoto, Yudai
AU - Takai, Tomoaki
AU - Minami, Koichiro
AU - Taniguchi, Kohei
AU - Tanaka, Tomohito
AU - Uehara, Hirofumi
AU - Hirano, Hajime
AU - Nomi, Hayahito
AU - Ibuki, Naokazu
AU - Takahara, Kiyoshi
AU - Inamoto, Teruo
AU - Azuma, Haruhito
N1 - Publisher Copyright:
© 2019, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2020/1/1
Y1 - 2020/1/1
N2 - This study aimed to assess the clinical value of C-reactive protein-albumin ratio (CAR) at the initiation of first-line treatment for castration-resistant prostate cancer (CRPC). We identified 221 CRPC patients treated with either androgen-signaling inhibitors (ASIs: abiraterone and enzalutamide) or docetaxel as the first-line treatment. The value of CAR was evaluated at the initiation of first-line treatment. The optimal cutoff value of CAR for the prediction of lethality was defined by the receiver operating characteristic curve and the Youden Index. The primary endpoints of the study included overall survival (OS) and cancer-specific survival (CSS). The median age was 74 years. The optimal cutoff value of CAR in newly diagnosed CRPC patients was 0.5 (CAR > 0.5: n = 77 and CAR ≤ 0.5: n = 144). The 3-year OS and CSS rate in patients with CAR > 0.5 were significantly lower than those with CAR ≤ 0.5 (OS: 30.9% vs 55.5%, p < 0.001) (CSS: 42.5% vs 65.4%, p < 0.001). A multivariate analysis consistently demonstrated that CAR was an independent predictor for both OS and CSS. When stratified by the first-line treatments, patients with CAR > 0.5 has significantly shorter CSS than those with CAR ≤ 0.5 in abiraterone (median of 23 vs 49 months, p < 0.001) and enzalutamide (median of 23 vs 41 months, p = 0.0016), whereas no difference was observed in patients treated with docetaxel as the first-line treatment (median of 34 and 37 months, p = 0.7708). Despite the limited cohort size and retrospective design, increased CAR seemed to serve as an independent predictor of OS and CSS for patients newly diagnosed with CRPC.
AB - This study aimed to assess the clinical value of C-reactive protein-albumin ratio (CAR) at the initiation of first-line treatment for castration-resistant prostate cancer (CRPC). We identified 221 CRPC patients treated with either androgen-signaling inhibitors (ASIs: abiraterone and enzalutamide) or docetaxel as the first-line treatment. The value of CAR was evaluated at the initiation of first-line treatment. The optimal cutoff value of CAR for the prediction of lethality was defined by the receiver operating characteristic curve and the Youden Index. The primary endpoints of the study included overall survival (OS) and cancer-specific survival (CSS). The median age was 74 years. The optimal cutoff value of CAR in newly diagnosed CRPC patients was 0.5 (CAR > 0.5: n = 77 and CAR ≤ 0.5: n = 144). The 3-year OS and CSS rate in patients with CAR > 0.5 were significantly lower than those with CAR ≤ 0.5 (OS: 30.9% vs 55.5%, p < 0.001) (CSS: 42.5% vs 65.4%, p < 0.001). A multivariate analysis consistently demonstrated that CAR was an independent predictor for both OS and CSS. When stratified by the first-line treatments, patients with CAR > 0.5 has significantly shorter CSS than those with CAR ≤ 0.5 in abiraterone (median of 23 vs 49 months, p < 0.001) and enzalutamide (median of 23 vs 41 months, p = 0.0016), whereas no difference was observed in patients treated with docetaxel as the first-line treatment (median of 34 and 37 months, p = 0.7708). Despite the limited cohort size and retrospective design, increased CAR seemed to serve as an independent predictor of OS and CSS for patients newly diagnosed with CRPC.
UR - http://www.scopus.com/inward/record.url?scp=85075376011&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85075376011&partnerID=8YFLogxK
U2 - 10.1007/s12032-019-1332-7
DO - 10.1007/s12032-019-1332-7
M3 - Article
C2 - 31754918
AN - SCOPUS:85075376011
SN - 1357-0560
VL - 37
JO - Medical Oncology
JF - Medical Oncology
IS - 1
M1 - 9
ER -