TY - JOUR
T1 - Prognostic impact of lipid contents on the target lesion in patients with drug eluting stent implantation
AU - Kumagai, Soichiro
AU - Takashima, Hiroaki
AU - Waseda, Katsuhisa
AU - Ando, Hirohiko
AU - Suzuki, Akihiro
AU - Uetani, Tadayuki
AU - Harada, Ken
AU - Yoshida, Tomohiro
AU - Kunimura, Ayako
AU - Shimbo, Yusaku
AU - Kitagawa, Katsuhide
AU - Harada, Kazuhiro
AU - Ishii, Hideki
AU - Yoshikawa, Daiji
AU - Matsubara, Tatsuaki
AU - Murohara, Toyoaki
AU - Amano, Tetsuya
N1 - Publisher Copyright:
© 2013, Springer Japan.
PY - 2013/11
Y1 - 2013/11
N2 - We sought to determine the morphologic predictors of major adverse cardiac events (MACEs) after successful percutaneous coronary intervention (PCI) with drug-eluting stents (DES), using integrated backscatter intravascular ultrasound (IB-IVUS). Conventional IVUS and IB-IVUS were performed in 260 consecutive patients who underwent PCI with DES. Three-dimensional analyses were performed to determine plaque volume and the volume of each plaque component (lipid, fibrous, and calcification). Patients were divided into two groups according to the median lipid volume (LV) in the target lesion. MACEs were defined as death, nonfatal myocardial infarction, and any repeat revascularization. The median follow-up interval was 1285 days. MACEs were observed in 64 patients (24.6 %). Patients having a larger LV compared with their counterparts had worse long-term clinical outcomes regarding mortality (3.8 vs. 0 %, P = 0.02) and MACEs (31.5 vs. 17.7 %, P = 0.008) by log-rank test. After adjustment for confounders, large LV (odds ratio 1.95, 95 % confidence interval 1.14–3.33, P = 0.02) was significantly and independently associated with MACEs. The assessment of coronary plaque characteristics in the target lesion may be useful to predict long-term outcome following successful coronary intervention.
AB - We sought to determine the morphologic predictors of major adverse cardiac events (MACEs) after successful percutaneous coronary intervention (PCI) with drug-eluting stents (DES), using integrated backscatter intravascular ultrasound (IB-IVUS). Conventional IVUS and IB-IVUS were performed in 260 consecutive patients who underwent PCI with DES. Three-dimensional analyses were performed to determine plaque volume and the volume of each plaque component (lipid, fibrous, and calcification). Patients were divided into two groups according to the median lipid volume (LV) in the target lesion. MACEs were defined as death, nonfatal myocardial infarction, and any repeat revascularization. The median follow-up interval was 1285 days. MACEs were observed in 64 patients (24.6 %). Patients having a larger LV compared with their counterparts had worse long-term clinical outcomes regarding mortality (3.8 vs. 0 %, P = 0.02) and MACEs (31.5 vs. 17.7 %, P = 0.008) by log-rank test. After adjustment for confounders, large LV (odds ratio 1.95, 95 % confidence interval 1.14–3.33, P = 0.02) was significantly and independently associated with MACEs. The assessment of coronary plaque characteristics in the target lesion may be useful to predict long-term outcome following successful coronary intervention.
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U2 - 10.1007/s00380-013-0430-2
DO - 10.1007/s00380-013-0430-2
M3 - Article
C2 - 24142068
AN - SCOPUS:84936748097
SN - 0910-8327
VL - 29
SP - 761
EP - 768
JO - Heart and Vessels
JF - Heart and Vessels
IS - 6
ER -