Prognostic impact of lipid contents on the target lesion in patients with drug eluting stent implantation

Soichiro Kumagai, Hiroaki Takashima, Katsuhisa Waseda, Hirohiko Ando, Akihiro Suzuki, Tadayuki Uetani, Ken Harada, Tomohiro Yoshida, Ayako Kunimura, Yusaku Shimbo, Katsuhide Kitagawa, Kazuhiro Harada, Hideki Ishii, Daiji Yoshikawa, Tatsuaki Matsubara, Toyoaki Murohara, Tetsuya Amano

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


We sought to determine the morphologic predictors of major adverse cardiac events (MACEs) after successful percutaneous coronary intervention (PCI) with drug-eluting stents (DES), using integrated backscatter intravascular ultrasound (IB-IVUS). Conventional IVUS and IB-IVUS were performed in 260 consecutive patients who underwent PCI with DES. Three-dimensional analyses were performed to determine plaque volume and the volume of each plaque component (lipid, fibrous, and calcification). Patients were divided into two groups according to the median lipid volume (LV) in the target lesion. MACEs were defined as death, nonfatal myocardial infarction, and any repeat revascularization. The median follow-up interval was 1285 days. MACEs were observed in 64 patients (24.6 %). Patients having a larger LV compared with their counterparts had worse long-term clinical outcomes regarding mortality (3.8 vs. 0 %, P = 0.02) and MACEs (31.5 vs. 17.7 %, P = 0.008) by log-rank test. After adjustment for confounders, large LV (odds ratio 1.95, 95 % confidence interval 1.14–3.33, P = 0.02) was significantly and independently associated with MACEs. The assessment of coronary plaque characteristics in the target lesion may be useful to predict long-term outcome following successful coronary intervention.

Original languageEnglish
Pages (from-to)761-768
Number of pages8
JournalHeart and Vessels
Issue number6
Publication statusPublished - 11-2013

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine


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