Prognostic impact of preoperative albumin-to-globulin ratio in patients with colon cancer undergoing surgery with curative intent

Hiroyuki Fujikawa; Yuji Toiyama; Yasuhiro Inoue; Hiroki Imaoka; Tadanobu Shimura; Masato Okigami; Hiromi Yasuda; Junichiro Hiro; Shigeyuki Yoshiyama; Susumu Saigusa; Minako Kobayashi; Masaki Ohi; Toshimitsu Araki; Yasuhiko Mohri; Masato Kusunoki

doi:10.21873/anticanres.11452

Prognostic impact of preoperative albumin-to-globulin ratio in patients with colon cancer undergoing surgery with curative intent

Hiroyuki Fujikawa, Yuji Toiyama, Yasuhiro Inoue, Hiroki Imaoka, Tadanobu Shimura, Masato Okigami, Hiromi Yasuda, Junichiro Hiro, Shigeyuki Yoshiyama, Susumu Saigusa, Minako Kobayashi, Masaki Ohi, Toshimitsu Araki, Yasuhiko Mohri, Masato Kusunoki

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

Aim: To identify predictors of poor prognosis of patients with colon cancer (CC) who underwent surgery with curative intent, we investigated the association between the albumin to globulin ratio (AGR) with clinicopathological findings such as overall (OS) and disease-free (DFS) survival. Patients and Methods: We conducted a retrospective study of clinicopathological findings, including preoperative laboratory data, for 248 patients with stage I-III CC. Results: Patients with low AGR had shorter DFS and OS compared to those with high AGR. Multivariate analyses identified low AGR as an independent variable independently associated with recurrence and poor prognosis of patients with CC who underwent surgery with curative intent regardless of lymphnode metastasis. Conclusion: The preoperative AGR was an independent predictor of recurrence and poor prognosis of patients with CC who underwent surgery with curative intent. The AGR indicates that these patients may benefit from intensive adjuvant therapy.

Original language	English
Pages (from-to)	1335-1342
Number of pages	8
Journal	Anticancer research
Volume	37
Issue number	3
DOIs	https://doi.org/10.21873/anticanres.11452
Publication status	Published - 03-2017
Externally published	Yes

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.21873/anticanres.11452

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Fujikawa, H., Toiyama, Y., Inoue, Y., Imaoka, H., Shimura, T., Okigami, M., Yasuda, H., Hiro, J., Yoshiyama, S., Saigusa, S., Kobayashi, M., Ohi, M., Araki, T., Mohri, Y., & Kusunoki, M. (2017). Prognostic impact of preoperative albumin-to-globulin ratio in patients with colon cancer undergoing surgery with curative intent. Anticancer research, 37(3), 1335-1342. https://doi.org/10.21873/anticanres.11452

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title = "Prognostic impact of preoperative albumin-to-globulin ratio in patients with colon cancer undergoing surgery with curative intent",

abstract = "Aim: To identify predictors of poor prognosis of patients with colon cancer (CC) who underwent surgery with curative intent, we investigated the association between the albumin to globulin ratio (AGR) with clinicopathological findings such as overall (OS) and disease-free (DFS) survival. Patients and Methods: We conducted a retrospective study of clinicopathological findings, including preoperative laboratory data, for 248 patients with stage I-III CC. Results: Patients with low AGR had shorter DFS and OS compared to those with high AGR. Multivariate analyses identified low AGR as an independent variable independently associated with recurrence and poor prognosis of patients with CC who underwent surgery with curative intent regardless of lymphnode metastasis. Conclusion: The preoperative AGR was an independent predictor of recurrence and poor prognosis of patients with CC who underwent surgery with curative intent. The AGR indicates that these patients may benefit from intensive adjuvant therapy.",

author = "Hiroyuki Fujikawa and Yuji Toiyama and Yasuhiro Inoue and Hiroki Imaoka and Tadanobu Shimura and Masato Okigami and Hiromi Yasuda and Junichiro Hiro and Shigeyuki Yoshiyama and Susumu Saigusa and Minako Kobayashi and Masaki Ohi and Toshimitsu Araki and Yasuhiko Mohri and Masato Kusunoki",

year = "2017",

month = mar,

doi = "10.21873/anticanres.11452",

language = "English",

volume = "37",

pages = "1335--1342",

journal = "Anticancer research",

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publisher = "International Institute of Anticancer Research",

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}

Fujikawa, H, Toiyama, Y, Inoue, Y, Imaoka, H, Shimura, T, Okigami, M, Yasuda, H, Hiro, J, Yoshiyama, S, Saigusa, S, Kobayashi, M, Ohi, M, Araki, T, Mohri, Y & Kusunoki, M 2017, 'Prognostic impact of preoperative albumin-to-globulin ratio in patients with colon cancer undergoing surgery with curative intent', Anticancer research, vol. 37, no. 3, pp. 1335-1342. https://doi.org/10.21873/anticanres.11452

TY - JOUR

T1 - Prognostic impact of preoperative albumin-to-globulin ratio in patients with colon cancer undergoing surgery with curative intent

AU - Fujikawa, Hiroyuki

AU - Toiyama, Yuji

AU - Inoue, Yasuhiro

AU - Imaoka, Hiroki

AU - Shimura, Tadanobu

AU - Okigami, Masato

AU - Yasuda, Hiromi

AU - Hiro, Junichiro

AU - Yoshiyama, Shigeyuki

AU - Saigusa, Susumu

AU - Kobayashi, Minako

AU - Ohi, Masaki

AU - Araki, Toshimitsu

AU - Mohri, Yasuhiko

AU - Kusunoki, Masato

PY - 2017/3

Y1 - 2017/3

N2 - Aim: To identify predictors of poor prognosis of patients with colon cancer (CC) who underwent surgery with curative intent, we investigated the association between the albumin to globulin ratio (AGR) with clinicopathological findings such as overall (OS) and disease-free (DFS) survival. Patients and Methods: We conducted a retrospective study of clinicopathological findings, including preoperative laboratory data, for 248 patients with stage I-III CC. Results: Patients with low AGR had shorter DFS and OS compared to those with high AGR. Multivariate analyses identified low AGR as an independent variable independently associated with recurrence and poor prognosis of patients with CC who underwent surgery with curative intent regardless of lymphnode metastasis. Conclusion: The preoperative AGR was an independent predictor of recurrence and poor prognosis of patients with CC who underwent surgery with curative intent. The AGR indicates that these patients may benefit from intensive adjuvant therapy.

AB - Aim: To identify predictors of poor prognosis of patients with colon cancer (CC) who underwent surgery with curative intent, we investigated the association between the albumin to globulin ratio (AGR) with clinicopathological findings such as overall (OS) and disease-free (DFS) survival. Patients and Methods: We conducted a retrospective study of clinicopathological findings, including preoperative laboratory data, for 248 patients with stage I-III CC. Results: Patients with low AGR had shorter DFS and OS compared to those with high AGR. Multivariate analyses identified low AGR as an independent variable independently associated with recurrence and poor prognosis of patients with CC who underwent surgery with curative intent regardless of lymphnode metastasis. Conclusion: The preoperative AGR was an independent predictor of recurrence and poor prognosis of patients with CC who underwent surgery with curative intent. The AGR indicates that these patients may benefit from intensive adjuvant therapy.

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Prognostic impact of preoperative albumin-to-globulin ratio in patients with colon cancer undergoing surgery with curative intent

Abstract

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