Prognostic Nutritional Index and Lung Immune Prognostic Index as Prognostic Predictors for Combination Therapies of Immune Checkpoint Inhibitors and Cytotoxic Anticancer Chemotherapy for Patients with Advanced Non-Small Cell Lung Cancer

Satomi Tanaka; Junji Uchino; Takashi Yokoi; Takashi Kijima; Yasuhiro Goto; Yoshifumi Suga; Yuki Katayama; Ryota Nakamura; Kenji Morimoto; Akira Nakao; Makoto Hibino; Nozomi Tani; Takayuki Takeda; Hiroyuki Yamaguchi; Yusuke Tachibana; Chieko Takumi; Noriya Hiraoka; Masafumi Takeshita; Keisuke Onoi; Yusuke Chihara; Ryusuke Taniguchi; Takahiro Yamada; Yohei Matsui; Osamu Hiranuma; Yoshie Morimoto; Masahiro Iwasaku; Shinsaku Tokuda; Yoshiko Kaneko; Tadaaki Yamada; Koichi Takayama

doi:10.3390/diagnostics12020423

Prognostic Nutritional Index and Lung Immune Prognostic Index as Prognostic Predictors for Combination Therapies of Immune Checkpoint Inhibitors and Cytotoxic Anticancer Chemotherapy for Patients with Advanced Non-Small Cell Lung Cancer

Satomi Tanaka
, Junji Uchino
, Takashi Yokoi
, Takashi Kijima
, Yasuhiro Goto
, Yoshifumi Suga
, Yuki Katayama
, Ryota Nakamura
, Kenji Morimoto
, Akira Nakao
, Makoto Hibino
, Nozomi Tani
, Takayuki Takeda
, Hiroyuki Yamaguchi
, Yusuke Tachibana
, Chieko Takumi
, Noriya Hiraoka
, Masafumi Takeshita
, Keisuke Onoi
, Yusuke Chihara

Ryusuke Taniguchi, Takahiro Yamada, Yohei Matsui, Osamu Hiranuma, Yoshie Morimoto, Masahiro Iwasaku, Shinsaku Tokuda, Yoshiko Kaneko, Tadaaki Yamada, Koichi Takayama

Respiratory Medicine & Clinical Allergy

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

Combination therapy with immune checkpoint inhibitors and cytotoxic chemotherapies (chemoimmunotherapy) is associated with significantly better survival outcomes than cytotoxic chemotherapies alone in patients with advanced non-small cell lung cancer (NSCLC). However, there are no prognostic markers for chemoimmunotherapy. The prognostic nutritional index (PNI) and lung immune prognostic index (LIPI) are prognostic biomarkers for immune checkpoint.

Original language	English
Article number	423
Journal	Diagnostics
Volume	12
Issue number	2
DOIs	https://doi.org/10.3390/diagnostics12020423
Publication status	Published - 02-2022

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Clinical Biochemistry

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Tanaka, S., Uchino, J., Yokoi, T., Kijima, T., Goto, Y., Suga, Y., Katayama, Y., Nakamura, R., Morimoto, K., Nakao, A., Hibino, M., Tani, N., Takeda, T., Yamaguchi, H., Tachibana, Y., Takumi, C., Hiraoka, N., Takeshita, M., Onoi, K., ... Takayama, K. (2022). Prognostic Nutritional Index and Lung Immune Prognostic Index as Prognostic Predictors for Combination Therapies of Immune Checkpoint Inhibitors and Cytotoxic Anticancer Chemotherapy for Patients with Advanced Non-Small Cell Lung Cancer. Diagnostics, 12(2), Article 423. https://doi.org/10.3390/diagnostics12020423

@article{884e41bd2b00437784f6f249b85feafd,

title = "Prognostic Nutritional Index and Lung Immune Prognostic Index as Prognostic Predictors for Combination Therapies of Immune Checkpoint Inhibitors and Cytotoxic Anticancer Chemotherapy for Patients with Advanced Non-Small Cell Lung Cancer",

abstract = "Combination therapy with immune checkpoint inhibitors and cytotoxic chemotherapies (chemoimmunotherapy) is associated with significantly better survival outcomes than cytotoxic chemotherapies alone in patients with advanced non-small cell lung cancer (NSCLC). However, there are no prognostic markers for chemoimmunotherapy. The prognostic nutritional index (PNI) and lung immune prognostic index (LIPI) are prognostic biomarkers for immune checkpoint.",

keywords = "Advanced non-small cell lung cancer, Chemoimmunotherapy, Lung immune prognostic index, Prognostic nutritional index, Programmed cell death ligand 1",

author = "Satomi Tanaka and Junji Uchino and Takashi Yokoi and Takashi Kijima and Yasuhiro Goto and Yoshifumi Suga and Yuki Katayama and Ryota Nakamura and Kenji Morimoto and Akira Nakao and Makoto Hibino and Nozomi Tani and Takayuki Takeda and Hiroyuki Yamaguchi and Yusuke Tachibana and Chieko Takumi and Noriya Hiraoka and Masafumi Takeshita and Keisuke Onoi and Yusuke Chihara and Ryusuke Taniguchi and Takahiro Yamada and Yohei Matsui and Osamu Hiranuma and Yoshie Morimoto and Masahiro Iwasaku and Shinsaku Tokuda and Yoshiko Kaneko and Tadaaki Yamada and Koichi Takayama",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

month = feb,

doi = "10.3390/diagnostics12020423",

language = "English",

volume = "12",

journal = "Diagnostics",

issn = "2075-4418",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "2",

}

Tanaka, S, Uchino, J, Yokoi, T, Kijima, T, Goto, Y, Suga, Y, Katayama, Y, Nakamura, R, Morimoto, K, Nakao, A, Hibino, M, Tani, N, Takeda, T, Yamaguchi, H, Tachibana, Y, Takumi, C, Hiraoka, N, Takeshita, M, Onoi, K, Chihara, Y, Taniguchi, R, Yamada, T, Matsui, Y, Hiranuma, O, Morimoto, Y, Iwasaku, M, Tokuda, S, Kaneko, Y, Yamada, T & Takayama, K 2022, 'Prognostic Nutritional Index and Lung Immune Prognostic Index as Prognostic Predictors for Combination Therapies of Immune Checkpoint Inhibitors and Cytotoxic Anticancer Chemotherapy for Patients with Advanced Non-Small Cell Lung Cancer', Diagnostics, vol. 12, no. 2, 423. https://doi.org/10.3390/diagnostics12020423

Prognostic Nutritional Index and Lung Immune Prognostic Index as Prognostic Predictors for Combination Therapies of Immune Checkpoint Inhibitors and Cytotoxic Anticancer Chemotherapy for Patients with Advanced Non-Small Cell Lung Cancer. / Tanaka, Satomi; Uchino, Junji; Yokoi, Takashi et al.
In: Diagnostics, Vol. 12, No. 2, 423, 02.2022.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Prognostic Nutritional Index and Lung Immune Prognostic Index as Prognostic Predictors for Combination Therapies of Immune Checkpoint Inhibitors and Cytotoxic Anticancer Chemotherapy for Patients with Advanced Non-Small Cell Lung Cancer

AU - Tanaka, Satomi

AU - Uchino, Junji

AU - Yokoi, Takashi

AU - Kijima, Takashi

AU - Goto, Yasuhiro

AU - Suga, Yoshifumi

AU - Katayama, Yuki

AU - Nakamura, Ryota

AU - Morimoto, Kenji

AU - Nakao, Akira

AU - Hibino, Makoto

AU - Tani, Nozomi

AU - Takeda, Takayuki

AU - Yamaguchi, Hiroyuki

AU - Tachibana, Yusuke

AU - Takumi, Chieko

AU - Hiraoka, Noriya

AU - Takeshita, Masafumi

AU - Onoi, Keisuke

AU - Chihara, Yusuke

AU - Taniguchi, Ryusuke

AU - Yamada, Takahiro

AU - Matsui, Yohei

AU - Hiranuma, Osamu

AU - Morimoto, Yoshie

AU - Iwasaku, Masahiro

AU - Tokuda, Shinsaku

AU - Kaneko, Yoshiko

AU - Yamada, Tadaaki

AU - Takayama, Koichi

PY - 2022/2

Y1 - 2022/2

N2 - Combination therapy with immune checkpoint inhibitors and cytotoxic chemotherapies (chemoimmunotherapy) is associated with significantly better survival outcomes than cytotoxic chemotherapies alone in patients with advanced non-small cell lung cancer (NSCLC). However, there are no prognostic markers for chemoimmunotherapy. The prognostic nutritional index (PNI) and lung immune prognostic index (LIPI) are prognostic biomarkers for immune checkpoint.

AB - Combination therapy with immune checkpoint inhibitors and cytotoxic chemotherapies (chemoimmunotherapy) is associated with significantly better survival outcomes than cytotoxic chemotherapies alone in patients with advanced non-small cell lung cancer (NSCLC). However, there are no prognostic markers for chemoimmunotherapy. The prognostic nutritional index (PNI) and lung immune prognostic index (LIPI) are prognostic biomarkers for immune checkpoint.

KW - Advanced non-small cell lung cancer

KW - Chemoimmunotherapy

KW - Lung immune prognostic index

KW - Prognostic nutritional index

KW - Programmed cell death ligand 1

UR - https://www.scopus.com/pages/publications/85124263716

UR - https://www.scopus.com/pages/publications/85124263716#tab=citedBy

U2 - 10.3390/diagnostics12020423

DO - 10.3390/diagnostics12020423

M3 - Article

AN - SCOPUS:85124263716

SN - 2075-4418

VL - 12

JO - Diagnostics

JF - Diagnostics

IS - 2

M1 - 423

ER -

Prognostic Nutritional Index and Lung Immune Prognostic Index as Prognostic Predictors for Combination Therapies of Immune Checkpoint Inhibitors and Cytotoxic Anticancer Chemotherapy for Patients with Advanced Non-Small Cell Lung Cancer

Abstract

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