TY - JOUR
T1 - Prognostic significance of l-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in stage I pulmonary adenocarcinoma
AU - Kaira, Kyoichi
AU - Oriuchi, Noboru
AU - Imai, Hisao
AU - Shimizu, Kimihiro
AU - Yanagitani, Noriko
AU - Sunaga, Noriaki
AU - Hisada, Takeshi
AU - Ishizuka, Tamotsu
AU - Kanai, Yoshikatsu
AU - Nakajima, Takashi
AU - Mori, Masatomo
PY - 2009/10
Y1 - 2009/10
N2 - Background: The purpose of this study was to evaluate the prognostic value of l-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in patients with stage I pulmonary adenocarcinoma. Methods: A total of 139 consecutive patients with pathologic stage I pulmonary adenocarcinoma were retrospectively reviewed. Expression of LAT1, CD98, Ki-67 labeling index, vascular endothelial growth factor (VEGF) and microvessel density (MVD) was also evaluated immunohistochemically and correlated with the prognosis of patients after complete resection of the tumor. Results: LAT1 and CD98 expression were positive in 23% (32/139) and 22% (31/139), respectively (p = 0.887). LAT1 with CD98 expression was recognized in 15% (21/139). LAT1 expression was significantly correlated with CD98, Ki-67 labeling index, VEGF, and MVD. The 5-year survival rates of LAT1-positive and -negative patients and CD98-positive and -negative patients, were 60.2 and 95.2% (p < 0.0001) and 72.5 and 93.4% (p = 0.0008), respectively. Univariate analysis disclosed that cellular proliferation and MVD in the tumor were significant prognostic factors. However, multivariate analysis confirmed that positive expression of LAT1 and CD98 was an independent factor for predicting a poor prognosis. Conclusion: The overexpression of LAT1 and CD98 is a pathological factor to predict the prognosis in patients with resectable stage I pulmonary adenocarcinoma.
AB - Background: The purpose of this study was to evaluate the prognostic value of l-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in patients with stage I pulmonary adenocarcinoma. Methods: A total of 139 consecutive patients with pathologic stage I pulmonary adenocarcinoma were retrospectively reviewed. Expression of LAT1, CD98, Ki-67 labeling index, vascular endothelial growth factor (VEGF) and microvessel density (MVD) was also evaluated immunohistochemically and correlated with the prognosis of patients after complete resection of the tumor. Results: LAT1 and CD98 expression were positive in 23% (32/139) and 22% (31/139), respectively (p = 0.887). LAT1 with CD98 expression was recognized in 15% (21/139). LAT1 expression was significantly correlated with CD98, Ki-67 labeling index, VEGF, and MVD. The 5-year survival rates of LAT1-positive and -negative patients and CD98-positive and -negative patients, were 60.2 and 95.2% (p < 0.0001) and 72.5 and 93.4% (p = 0.0008), respectively. Univariate analysis disclosed that cellular proliferation and MVD in the tumor were significant prognostic factors. However, multivariate analysis confirmed that positive expression of LAT1 and CD98 was an independent factor for predicting a poor prognosis. Conclusion: The overexpression of LAT1 and CD98 is a pathological factor to predict the prognosis in patients with resectable stage I pulmonary adenocarcinoma.
KW - Amino acid transporter
KW - Angiogenesis
KW - CD98
KW - Ki-67
KW - LAT1
KW - Prognostic factor
KW - Pulmonary adenocarcinoma
UR - https://www.scopus.com/pages/publications/68949201631
UR - https://www.scopus.com/inward/citedby.url?scp=68949201631&partnerID=8YFLogxK
U2 - 10.1016/j.lungcan.2008.12.015
DO - 10.1016/j.lungcan.2008.12.015
M3 - Article
C2 - 19171406
AN - SCOPUS:68949201631
SN - 0169-5002
VL - 66
SP - 120
EP - 126
JO - Lung Cancer
JF - Lung Cancer
IS - 1
ER -
