TY - JOUR
T1 - Prognostic Significance of Platelet-Based Inflammatory Indicators in Patients with Gastric Cancer
AU - Saito, Hiroaki
AU - Kono, Yusuke
AU - Murakami, Yuki
AU - Shishido, Yuji
AU - Kuroda, Hirohiko
AU - Matsunaga, Tomoyuki
AU - Fukumoto, Yoji
AU - Osaki, Tomohiro
AU - Ashida, Keigo
AU - Fujiwara, Yoshiyuki
N1 - Publisher Copyright:
© 2018, Société Internationale de Chirurgie.
PY - 2018/8/1
Y1 - 2018/8/1
N2 - Background: Thrombocytosis develops in association with malignant tumors and may reflect the inflammation status in cancer patients. This study retrospectively investigated the prognostic significance of two platelet-based inflammatory indicators, the platelet × C-reactive protein multiplier value (P-CRP), and platelet-lymphocyte ratio (PLR), in gastric cancer patients. Methods: The 453 enrolled patients had a histopathological diagnosis of gastric adenocarcinoma and underwent curative surgery. Results: P-CRP correlated significantly with age, tumor size, depth of invasion, lymph node metastasis, and disease stage. A high PLR correlated significantly with tumor size, depth of invasion, lymph node metastasis, lymphatic involvement, venous involvement, and disease stage. In the ROC analysis, the optimal cutoff value of P-CRP and PLR was 3.689 and 173.3, respectively. Five-year survival rates were 62.9 and 82.1% in patients with P-CRPHigh (≥3.689) and P-CRPLow (<3.698), respectively (P < 0.0001). Five-year survival rates were 66.3 and 81.3% in patients with PLRHigh (≥173.3) and PLRLow (<173.3), respectively (P = 0.0022). The prognosis of the P-CRPHigh/PLRHigh group was significantly worse than that of the P-CRPHigh or PLRHigh and P-CRPLow/PLRLow groups in terms of overall survival (P < 0.0001) and disease-specific survival (P = 0.029). In a multivariate analysis, the combination of P-CRP and PLR was an independent prognostic indicator. Conclusions: The combination of P-CRP and PLR may be useful in predicting prognosis in gastric cancer patients.
AB - Background: Thrombocytosis develops in association with malignant tumors and may reflect the inflammation status in cancer patients. This study retrospectively investigated the prognostic significance of two platelet-based inflammatory indicators, the platelet × C-reactive protein multiplier value (P-CRP), and platelet-lymphocyte ratio (PLR), in gastric cancer patients. Methods: The 453 enrolled patients had a histopathological diagnosis of gastric adenocarcinoma and underwent curative surgery. Results: P-CRP correlated significantly with age, tumor size, depth of invasion, lymph node metastasis, and disease stage. A high PLR correlated significantly with tumor size, depth of invasion, lymph node metastasis, lymphatic involvement, venous involvement, and disease stage. In the ROC analysis, the optimal cutoff value of P-CRP and PLR was 3.689 and 173.3, respectively. Five-year survival rates were 62.9 and 82.1% in patients with P-CRPHigh (≥3.689) and P-CRPLow (<3.698), respectively (P < 0.0001). Five-year survival rates were 66.3 and 81.3% in patients with PLRHigh (≥173.3) and PLRLow (<173.3), respectively (P = 0.0022). The prognosis of the P-CRPHigh/PLRHigh group was significantly worse than that of the P-CRPHigh or PLRHigh and P-CRPLow/PLRLow groups in terms of overall survival (P < 0.0001) and disease-specific survival (P = 0.029). In a multivariate analysis, the combination of P-CRP and PLR was an independent prognostic indicator. Conclusions: The combination of P-CRP and PLR may be useful in predicting prognosis in gastric cancer patients.
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U2 - 10.1007/s00268-018-4527-8
DO - 10.1007/s00268-018-4527-8
M3 - Article
C2 - 29464343
AN - SCOPUS:85042236131
SN - 0364-2313
VL - 42
SP - 2542
EP - 2550
JO - World Journal of Surgery
JF - World Journal of Surgery
IS - 8
ER -
