Prognostic significance of Wilms tumor 1 mRNA expression levels in peripheral blood and bone marrow in patients with myelodysplastic syndromes

Sumiko Kobayashi, Yasunori Ueda, Yasuhito Nannya, Hirohiko Shibayama, Hideto Tamura, Kiyoyuki Ogata, Yoshiki Akatsuka, Kensuke Usuki, Yoshikazu Ito, Masaya Okada, Takahiro Suzuki, Tomoko Hata, Akira Matsuda, Kaoru Tohyama, Keiji Kakumoto, Daisuke Koga, Kinuko Mitani, Tomoki Naoe, Haruo Sugiyama, Fumimaro Takaku

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6 Citations (Scopus)

Abstract

BACKGROUND: This present study was designed to follow up 82 patients among 115 MDS patients registered in study ODK- 0801 for 5 years, to analyze the relationship between the WT1 mRNA expression level and prognosis. OBJECTIVE: This study aimed to investigate the clinical utility of WT1 mRNA expression levels. METHODS: After study ODK-0801, we investigated the conditions of the same patients once a year, including any clinical and laboratory findings supporting the diagnosis, and treatment among the living patients. RESULTS: When we assessed the survival time of 82 MDS patients by WT1 mRNA expression level, there were significant differences between the < 500 and ≥ 104 copies/μg RNA groups and between the 500-104 and ≥ 104 copies/μg RNA groups for BM levels (p < 0.01). Examination of the time of freedom from acute myeloid leukemia (AML) transformation indicated that a high WT1 mRNA expression level (> 104 copies/μg RNA) was a strong prognostic factor for a short time to AML transformation. CONCLUSION: The results indicate that the tumorigenesis of MDS is likely to originate at the stem cell level, suggesting that the WT1 mRNA level measurement in the BM is an effective prognostic marker in patients with MDS.

Original languageEnglish
Pages (from-to)21-32
Number of pages12
JournalCancer Biomarkers
Volume17
Issue number1
DOIs
Publication statusPublished - 2016

All Science Journal Classification (ASJC) codes

  • Oncology
  • Genetics
  • Cancer Research

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    Kobayashi, S., Ueda, Y., Nannya, Y., Shibayama, H., Tamura, H., Ogata, K., Akatsuka, Y., Usuki, K., Ito, Y., Okada, M., Suzuki, T., Hata, T., Matsuda, A., Tohyama, K., Kakumoto, K., Koga, D., Mitani, K., Naoe, T., Sugiyama, H., & Takaku, F. (2016). Prognostic significance of Wilms tumor 1 mRNA expression levels in peripheral blood and bone marrow in patients with myelodysplastic syndromes. Cancer Biomarkers, 17(1), 21-32. https://doi.org/10.3233/CBM-160612