Prognostic value of CD208-positive cell infiltration in gastric cancer

Sumiya Ishigami, Shinichi Ueno, Masataka Matsumoto, Hiroshi Okumura, Takaaki Arigami, Yasuto Uchikado, Tetsuro Setoyama, Hideo Arima, Ken Sasaki, Masaki Kitazono, Hiroyuki Shinchi, Yuko Kijima, Shoji Natsugoe

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

Background and aim: A new marker, CD208, was recently explored as a mature interdigitating dendritic cell (DC), and the correlation between the infiltration of CD208-positive cells and clinical factors has been reported in various types of cancers. In this study, we tried to clarify the clinical implication of CD208-positive cell infiltration in gastric cancer immunohistochemically. Patients and methods: A total of 128 gastric cancer patients who underwent a curative operation were enrolled. DCs in tumor nests were identified with two DC markers, CD208 and S-100 protein (S100), by immunohistochemistry. The correlation between clinicopathological features and the CD208- or S100-positive cell infiltration degree was analyzed. Results: Infiltration of S100-positive cells did not correlate with the degree of CD208-positive cell infiltration. Patients with high CD208-positive cell infiltration in the peritumor had a poorer surgical outcome than those with low CD208 infiltration (p < 0.05). Multivariate analysis revealed that CD208-positive cell infiltration was not an independent prognostic factor. Conclusion: We showed that intratumoral CD208-positive cells, as mature DCs, had an inverse correlation to patients' postoperative outcome in gastric cancer, unlike a conventional DC marker. Evaluation of CD208-positive cell infiltration with S100-positive cell infiltration in gastric cancer is useful to predict antitumor immunological conditions in gastric cancer.

Original languageEnglish
Pages (from-to)389-395
Number of pages7
JournalCancer Immunology, Immunotherapy
Volume59
Issue number3
DOIs
Publication statusPublished - 01-03-2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Oncology
  • Cancer Research

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