Prognostic value of combined tumor marker and controlling nutritional status (CONUT) score in colorectal cancer patients

Manabu Yamamoto, Hiroaki Saito, Chihiro Uejima, Akimitsu Tanio, Yoichiro Tada, Tomoyuki Matsunaga, Teruhisa Sakamoto, Soichiro Honjo, Keigo Ashida, Yoshiyuki Fujiwara

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15 Citations (Scopus)


Background Nutritional status is strongly associated with prognosis in cancer patients. Controlling Nutritional Status (CONUT) score is a nutritional marker based on serum albumin, cholesterol, and total lymphocyte count. We investigated the prognostic significance of a combination of the tumor marker carcinoembryonic antigen (CEA) and CONUT score (T-CONUT) in colorectal cancer (CRC) patients. Methods A total of 522 patients who underwent surgery for CRC at our hospital were retrospectively enrolled in this study. Results Patients were divided into groups based on the results of receiver operating characteristic (ROC) curve analysis as follows: CONUThigh (CONUT score ≥ 3) and CONUTlow (CONUT score < 3), and CEAlow (< 5 ng/mL) and CEAhigh (≥ 5 ng/mL). The 5-year overall survival (OS) rates of patients in the CONUTlow and CONUThigh groups were 76.0% and 53.9%, respectively (P < 0.0001), and in the CEAlow and CEAhigh groups were 80.7% and 47.6%, respectively (P < 0.0001). Regarding T-CONUT, the 5-year OS rates of patients with CEAlow/CONUTlow, CEAlow/CONUThigh, CEAhigh/CONUTlow, and CEAhigh/ CONUThigh were 84.7%, 69%, 55.3%, and 36.1%, respectively (P < 0.0001). Multivariate analysis identified T-CONUT score as an independent prognostic indicator in CRC patients. Conclusion T-CONUT may be a useful tool for predicting prognosis in CRC patients.

Original languageEnglish
Pages (from-to)124-130
Number of pages7
JournalYonago Acta Medica
Issue number1
Publication statusPublished - 2019

All Science Journal Classification (ASJC) codes

  • Medicine(all)


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