Prognostic value of left atrial volume index in patents with first acute myocardial infarction

Eirin Sakaguchi, Akira Yamada, Kunihiko Sugimoto, Yoshihiro Ito, Kenji Shiino, Kayoko Takada, Masatsugu Iwase, Yukio Ozaki

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Aims: We evaluated the usefulness of left atrial volume index (LAVI) and the degree of changes in LAVI (delta LAVI) during hospitalization for the prediction of prognosis after acute myocardial infarction (AMI) Methods and results: We investigated 205 consecutive patients with first AMI. They underwent echocardiography on admission as well as at discharge. Delta LAVI was calculated by subtracting the value on admission from that at discharge. The primary endpoints were major cardiac events (MACE): cardiac death due to heart failure and heart failure hospitalization. During a mean follow-up of 26 months, MACE occurred in 29 patients. Patients were divided into two groups according to the optimal cut-off values of LAVI (32.0 mL/m2) at discharge and delta LAVI (2.5 mL/m2) derived from receiver operating characteristic curves, respectively; Group I: LAVI ≤ 32.0 mL/m2, Group II: LAVI > 32.0 mL/m2 and Group A: delta LAVI ≤ 2.5 mL/m2, Group B: delta LAVI > 2.5 mL/m2. In comparisons of two groups, respectively, the incidence of MACE between the groups showed significant differences [Group I (3.8%) vs. Group II (32.0%): P < 0.001, log-rank, Group A (7.4%) vs. Group B (20.0%): P = 0.0079, log-rank]. In multivariate analysis, LAVI at discharge [risk ratio (RR): 1.077, 95% CI: 1.035-1.124, P = 0.0002] and delta LAVI (RR: 1.056, 95% CI: 1.012-1.108, P = 0.0109) were significant. LAVI > 32.0 mL/m2 at discharge (sensitivity: 93%, specificity: 69%) and delta LAVI > 2.5 mL/m2 (sensitivity: 79%, specificity: 50%) were predictors of MACE. Conclusion: LAVI at discharge and delta LAVI would be useful predictors for MACE after first AMI.

Original languageEnglish
Pages (from-to)440-444
Number of pages5
JournalEuropean Journal of Echocardiography
Volume12
Issue number6
DOIs
Publication statusPublished - 01-06-2011

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Patents
Myocardial Infarction
Hospitalization
Heart Failure
Sensitivity and Specificity
ROC Curve
Echocardiography
Incidence

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Sakaguchi, Eirin ; Yamada, Akira ; Sugimoto, Kunihiko ; Ito, Yoshihiro ; Shiino, Kenji ; Takada, Kayoko ; Iwase, Masatsugu ; Ozaki, Yukio. / Prognostic value of left atrial volume index in patents with first acute myocardial infarction. In: European Journal of Echocardiography. 2011 ; Vol. 12, No. 6. pp. 440-444.
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abstract = "Aims: We evaluated the usefulness of left atrial volume index (LAVI) and the degree of changes in LAVI (delta LAVI) during hospitalization for the prediction of prognosis after acute myocardial infarction (AMI) Methods and results: We investigated 205 consecutive patients with first AMI. They underwent echocardiography on admission as well as at discharge. Delta LAVI was calculated by subtracting the value on admission from that at discharge. The primary endpoints were major cardiac events (MACE): cardiac death due to heart failure and heart failure hospitalization. During a mean follow-up of 26 months, MACE occurred in 29 patients. Patients were divided into two groups according to the optimal cut-off values of LAVI (32.0 mL/m2) at discharge and delta LAVI (2.5 mL/m2) derived from receiver operating characteristic curves, respectively; Group I: LAVI ≤ 32.0 mL/m2, Group II: LAVI > 32.0 mL/m2 and Group A: delta LAVI ≤ 2.5 mL/m2, Group B: delta LAVI > 2.5 mL/m2. In comparisons of two groups, respectively, the incidence of MACE between the groups showed significant differences [Group I (3.8{\%}) vs. Group II (32.0{\%}): P < 0.001, log-rank, Group A (7.4{\%}) vs. Group B (20.0{\%}): P = 0.0079, log-rank]. In multivariate analysis, LAVI at discharge [risk ratio (RR): 1.077, 95{\%} CI: 1.035-1.124, P = 0.0002] and delta LAVI (RR: 1.056, 95{\%} CI: 1.012-1.108, P = 0.0109) were significant. LAVI > 32.0 mL/m2 at discharge (sensitivity: 93{\%}, specificity: 69{\%}) and delta LAVI > 2.5 mL/m2 (sensitivity: 79{\%}, specificity: 50{\%}) were predictors of MACE. Conclusion: LAVI at discharge and delta LAVI would be useful predictors for MACE after first AMI.",
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Prognostic value of left atrial volume index in patents with first acute myocardial infarction. / Sakaguchi, Eirin; Yamada, Akira; Sugimoto, Kunihiko; Ito, Yoshihiro; Shiino, Kenji; Takada, Kayoko; Iwase, Masatsugu; Ozaki, Yukio.

In: European Journal of Echocardiography, Vol. 12, No. 6, 01.06.2011, p. 440-444.

Research output: Contribution to journalArticle

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T1 - Prognostic value of left atrial volume index in patents with first acute myocardial infarction

AU - Sakaguchi, Eirin

AU - Yamada, Akira

AU - Sugimoto, Kunihiko

AU - Ito, Yoshihiro

AU - Shiino, Kenji

AU - Takada, Kayoko

AU - Iwase, Masatsugu

AU - Ozaki, Yukio

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N2 - Aims: We evaluated the usefulness of left atrial volume index (LAVI) and the degree of changes in LAVI (delta LAVI) during hospitalization for the prediction of prognosis after acute myocardial infarction (AMI) Methods and results: We investigated 205 consecutive patients with first AMI. They underwent echocardiography on admission as well as at discharge. Delta LAVI was calculated by subtracting the value on admission from that at discharge. The primary endpoints were major cardiac events (MACE): cardiac death due to heart failure and heart failure hospitalization. During a mean follow-up of 26 months, MACE occurred in 29 patients. Patients were divided into two groups according to the optimal cut-off values of LAVI (32.0 mL/m2) at discharge and delta LAVI (2.5 mL/m2) derived from receiver operating characteristic curves, respectively; Group I: LAVI ≤ 32.0 mL/m2, Group II: LAVI > 32.0 mL/m2 and Group A: delta LAVI ≤ 2.5 mL/m2, Group B: delta LAVI > 2.5 mL/m2. In comparisons of two groups, respectively, the incidence of MACE between the groups showed significant differences [Group I (3.8%) vs. Group II (32.0%): P < 0.001, log-rank, Group A (7.4%) vs. Group B (20.0%): P = 0.0079, log-rank]. In multivariate analysis, LAVI at discharge [risk ratio (RR): 1.077, 95% CI: 1.035-1.124, P = 0.0002] and delta LAVI (RR: 1.056, 95% CI: 1.012-1.108, P = 0.0109) were significant. LAVI > 32.0 mL/m2 at discharge (sensitivity: 93%, specificity: 69%) and delta LAVI > 2.5 mL/m2 (sensitivity: 79%, specificity: 50%) were predictors of MACE. Conclusion: LAVI at discharge and delta LAVI would be useful predictors for MACE after first AMI.

AB - Aims: We evaluated the usefulness of left atrial volume index (LAVI) and the degree of changes in LAVI (delta LAVI) during hospitalization for the prediction of prognosis after acute myocardial infarction (AMI) Methods and results: We investigated 205 consecutive patients with first AMI. They underwent echocardiography on admission as well as at discharge. Delta LAVI was calculated by subtracting the value on admission from that at discharge. The primary endpoints were major cardiac events (MACE): cardiac death due to heart failure and heart failure hospitalization. During a mean follow-up of 26 months, MACE occurred in 29 patients. Patients were divided into two groups according to the optimal cut-off values of LAVI (32.0 mL/m2) at discharge and delta LAVI (2.5 mL/m2) derived from receiver operating characteristic curves, respectively; Group I: LAVI ≤ 32.0 mL/m2, Group II: LAVI > 32.0 mL/m2 and Group A: delta LAVI ≤ 2.5 mL/m2, Group B: delta LAVI > 2.5 mL/m2. In comparisons of two groups, respectively, the incidence of MACE between the groups showed significant differences [Group I (3.8%) vs. Group II (32.0%): P < 0.001, log-rank, Group A (7.4%) vs. Group B (20.0%): P = 0.0079, log-rank]. In multivariate analysis, LAVI at discharge [risk ratio (RR): 1.077, 95% CI: 1.035-1.124, P = 0.0002] and delta LAVI (RR: 1.056, 95% CI: 1.012-1.108, P = 0.0109) were significant. LAVI > 32.0 mL/m2 at discharge (sensitivity: 93%, specificity: 69%) and delta LAVI > 2.5 mL/m2 (sensitivity: 79%, specificity: 50%) were predictors of MACE. Conclusion: LAVI at discharge and delta LAVI would be useful predictors for MACE after first AMI.

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