TY - JOUR
T1 - Prognostic value of the combination of pre- and postoperative C-reactive protein in colorectal cancer patients
AU - Yamamoto, Manabu
AU - Saito, Hiroaki
AU - Uejima, Chihiro
AU - Tanio, Akimitsu
AU - Takaya, Seigo
AU - Sakamoto, Teruhisa
AU - Honjo, Soichiro
AU - Maeta, Yoshihiko
AU - Ashida, Keigo
AU - Fujiwara, Yoshiyuki
N1 - Publisher Copyright:
© 2018, Springer Nature Singapore Pte Ltd.
PY - 2018/11/1
Y1 - 2018/11/1
N2 - Purpose: Inflammation is closely related to cancer development and progression. This retrospective study investigated the prognostic value of the combination of pre- and postoperative C-reactive protein (CRP) levels in patients with colorectal cancer (CRC). Methods: The subjects of this study were 406 patients who underwent surgery for CRC. Results: Based on receiver-operating characteristic analysis, patients were divided into the following groups: those with a preoperative CRP of ≥ 0.5 mg/dL (pre-CRPHigh), those with a preoperative CRP of < 0.5 mg/dL (pre-CRPLow), those with a postoperative CRP of ≥ 17.0 mg/dL (post-CRPHigh), and those with a postoperative CRP of < 17.0 mg/dL (post-CRPLow). They were then allocated to one of the following three groups: Group A, comprised of those in the pre-CRPHigh and post-CRPHigh groups; Group B, comprised of those in either the pre-CRPHigh and post-CRPLow or pre-CRPLow and post-CRPHigh groups; and Group C, comprised of those in the pre-CRPLow and post-CRPLow groups. The disease-specific 5-year survival rates were 53.8%, 72.8%, and 87.2% in Groups A, B, and C, respectively, and these differences were significant. Finally, multivariate analysis revealed that the combination of pre- and postoperative CRP levels was an independent prognostic indicator. Conclusions: The combination of pre- and postoperative CRP was predictive of the prognosis of CRC patients.
AB - Purpose: Inflammation is closely related to cancer development and progression. This retrospective study investigated the prognostic value of the combination of pre- and postoperative C-reactive protein (CRP) levels in patients with colorectal cancer (CRC). Methods: The subjects of this study were 406 patients who underwent surgery for CRC. Results: Based on receiver-operating characteristic analysis, patients were divided into the following groups: those with a preoperative CRP of ≥ 0.5 mg/dL (pre-CRPHigh), those with a preoperative CRP of < 0.5 mg/dL (pre-CRPLow), those with a postoperative CRP of ≥ 17.0 mg/dL (post-CRPHigh), and those with a postoperative CRP of < 17.0 mg/dL (post-CRPLow). They were then allocated to one of the following three groups: Group A, comprised of those in the pre-CRPHigh and post-CRPHigh groups; Group B, comprised of those in either the pre-CRPHigh and post-CRPLow or pre-CRPLow and post-CRPHigh groups; and Group C, comprised of those in the pre-CRPLow and post-CRPLow groups. The disease-specific 5-year survival rates were 53.8%, 72.8%, and 87.2% in Groups A, B, and C, respectively, and these differences were significant. Finally, multivariate analysis revealed that the combination of pre- and postoperative CRP levels was an independent prognostic indicator. Conclusions: The combination of pre- and postoperative CRP was predictive of the prognosis of CRC patients.
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U2 - 10.1007/s00595-018-1689-9
DO - 10.1007/s00595-018-1689-9
M3 - Article
C2 - 29946884
AN - SCOPUS:85049103555
SN - 0941-1291
VL - 48
SP - 986
EP - 993
JO - Surgery Today
JF - Surgery Today
IS - 11
ER -
