Prognostic values of C-reactive protein levels on clinical outcome after mplantation of sirolimus-eluting stents in patients on hemodialysise

Hideki Ishii, Takanobu Toriyama, Toru Aoyama, Hiroshi Takahashi, Tetsuya Amano, Mutsuharu Hayashi, Miho Tanaka, Yoshihiro Kawamura, Yoshinari Yasuda, Yukio Yuzawa, Shoichi Maruyama, Seiichi Matsuo, Tatsuaki Matsubara, Toyoaki Murohara

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Abstract

Background - Percutaneous coronary intervention (PCI) using drug-eluting stents significantly reduces the risk of restenosis in the general population. However, in patients on hemodialysis, adverse cardiac events are frequently seen even if treated with drug-eluting stents. Recent studies suggest that C-reactive protein (CRP) reflects vascular wall inflammation and can predict adverse cardiac events. We evaluated possible prognostic values of CRP on outcomes in patients on hemodialysis undergoing PCI with drug eluting stents. Methods and Results - A total of 167 patients undergoing PCI with sirolimus-eluting stents for stable angina (322 lesions) were enrolled. They were divided into tertiles according to serum CRP levels. We analyzed the incidence of major adverse cardiovascular events including cardiovascular death, nonfatal myocardial infarction, and target lesion revascularization after PCI as well as quantitative coronary angiographic data. The mean follow-up was 31 months (SD, 14). Major adverse cardiac events occurred in 11 patients (19.6%) of the lowest tertile, in 22 patients (39.3%) of the middle tertile, and in 28 patients (50.9%) of the highest tertile during follow-up period (P=0.0009). There was a progressive increase in neointimal growth after sirolimus-eluting stent implantation during follow-up because preprocedural CRP levels were higher, despite similar angiographic data just after PCI. Angiographic restenosis at 6 to 8 months after PCI was seen in 10.6% in the lowest tertile, 17.9% in the middle tertile, and 32.0% in the highest tertile (P=0.0007). Conclusions - Increased preprocedural serum CRP levels would predict higher major adverse cardiac events and restenosis rates after sirolimus-eluting stents implantation in patients on hemodialysis.

Original languageEnglish
Pages (from-to)513-518
Number of pages6
JournalCirculation: Cardiovascular Interventions
Volume2
Issue number6
DOIs
Publication statusPublished - 01-12-2009
Externally publishedYes

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Sirolimus
C-Reactive Protein
Percutaneous Coronary Intervention
Stents
Drug-Eluting Stents
Renal Dialysis
Blood Proteins
Stable Angina
Blood Vessels
Myocardial Infarction
Inflammation
Incidence
Growth
Population

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Ishii, Hideki ; Toriyama, Takanobu ; Aoyama, Toru ; Takahashi, Hiroshi ; Amano, Tetsuya ; Hayashi, Mutsuharu ; Tanaka, Miho ; Kawamura, Yoshihiro ; Yasuda, Yoshinari ; Yuzawa, Yukio ; Maruyama, Shoichi ; Matsuo, Seiichi ; Matsubara, Tatsuaki ; Murohara, Toyoaki. / Prognostic values of C-reactive protein levels on clinical outcome after mplantation of sirolimus-eluting stents in patients on hemodialysise. In: Circulation: Cardiovascular Interventions. 2009 ; Vol. 2, No. 6. pp. 513-518.
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title = "Prognostic values of C-reactive protein levels on clinical outcome after mplantation of sirolimus-eluting stents in patients on hemodialysise",
abstract = "Background - Percutaneous coronary intervention (PCI) using drug-eluting stents significantly reduces the risk of restenosis in the general population. However, in patients on hemodialysis, adverse cardiac events are frequently seen even if treated with drug-eluting stents. Recent studies suggest that C-reactive protein (CRP) reflects vascular wall inflammation and can predict adverse cardiac events. We evaluated possible prognostic values of CRP on outcomes in patients on hemodialysis undergoing PCI with drug eluting stents. Methods and Results - A total of 167 patients undergoing PCI with sirolimus-eluting stents for stable angina (322 lesions) were enrolled. They were divided into tertiles according to serum CRP levels. We analyzed the incidence of major adverse cardiovascular events including cardiovascular death, nonfatal myocardial infarction, and target lesion revascularization after PCI as well as quantitative coronary angiographic data. The mean follow-up was 31 months (SD, 14). Major adverse cardiac events occurred in 11 patients (19.6{\%}) of the lowest tertile, in 22 patients (39.3{\%}) of the middle tertile, and in 28 patients (50.9{\%}) of the highest tertile during follow-up period (P=0.0009). There was a progressive increase in neointimal growth after sirolimus-eluting stent implantation during follow-up because preprocedural CRP levels were higher, despite similar angiographic data just after PCI. Angiographic restenosis at 6 to 8 months after PCI was seen in 10.6{\%} in the lowest tertile, 17.9{\%} in the middle tertile, and 32.0{\%} in the highest tertile (P=0.0007). Conclusions - Increased preprocedural serum CRP levels would predict higher major adverse cardiac events and restenosis rates after sirolimus-eluting stents implantation in patients on hemodialysis.",
author = "Hideki Ishii and Takanobu Toriyama and Toru Aoyama and Hiroshi Takahashi and Tetsuya Amano and Mutsuharu Hayashi and Miho Tanaka and Yoshihiro Kawamura and Yoshinari Yasuda and Yukio Yuzawa and Shoichi Maruyama and Seiichi Matsuo and Tatsuaki Matsubara and Toyoaki Murohara",
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Ishii, H, Toriyama, T, Aoyama, T, Takahashi, H, Amano, T, Hayashi, M, Tanaka, M, Kawamura, Y, Yasuda, Y, Yuzawa, Y, Maruyama, S, Matsuo, S, Matsubara, T & Murohara, T 2009, 'Prognostic values of C-reactive protein levels on clinical outcome after mplantation of sirolimus-eluting stents in patients on hemodialysise', Circulation: Cardiovascular Interventions, vol. 2, no. 6, pp. 513-518. https://doi.org/10.1161/CIRCINTERVENTIONS.109.889915

Prognostic values of C-reactive protein levels on clinical outcome after mplantation of sirolimus-eluting stents in patients on hemodialysise. / Ishii, Hideki; Toriyama, Takanobu; Aoyama, Toru; Takahashi, Hiroshi; Amano, Tetsuya; Hayashi, Mutsuharu; Tanaka, Miho; Kawamura, Yoshihiro; Yasuda, Yoshinari; Yuzawa, Yukio; Maruyama, Shoichi; Matsuo, Seiichi; Matsubara, Tatsuaki; Murohara, Toyoaki.

In: Circulation: Cardiovascular Interventions, Vol. 2, No. 6, 01.12.2009, p. 513-518.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prognostic values of C-reactive protein levels on clinical outcome after mplantation of sirolimus-eluting stents in patients on hemodialysise

AU - Ishii, Hideki

AU - Toriyama, Takanobu

AU - Aoyama, Toru

AU - Takahashi, Hiroshi

AU - Amano, Tetsuya

AU - Hayashi, Mutsuharu

AU - Tanaka, Miho

AU - Kawamura, Yoshihiro

AU - Yasuda, Yoshinari

AU - Yuzawa, Yukio

AU - Maruyama, Shoichi

AU - Matsuo, Seiichi

AU - Matsubara, Tatsuaki

AU - Murohara, Toyoaki

PY - 2009/12/1

Y1 - 2009/12/1

N2 - Background - Percutaneous coronary intervention (PCI) using drug-eluting stents significantly reduces the risk of restenosis in the general population. However, in patients on hemodialysis, adverse cardiac events are frequently seen even if treated with drug-eluting stents. Recent studies suggest that C-reactive protein (CRP) reflects vascular wall inflammation and can predict adverse cardiac events. We evaluated possible prognostic values of CRP on outcomes in patients on hemodialysis undergoing PCI with drug eluting stents. Methods and Results - A total of 167 patients undergoing PCI with sirolimus-eluting stents for stable angina (322 lesions) were enrolled. They were divided into tertiles according to serum CRP levels. We analyzed the incidence of major adverse cardiovascular events including cardiovascular death, nonfatal myocardial infarction, and target lesion revascularization after PCI as well as quantitative coronary angiographic data. The mean follow-up was 31 months (SD, 14). Major adverse cardiac events occurred in 11 patients (19.6%) of the lowest tertile, in 22 patients (39.3%) of the middle tertile, and in 28 patients (50.9%) of the highest tertile during follow-up period (P=0.0009). There was a progressive increase in neointimal growth after sirolimus-eluting stent implantation during follow-up because preprocedural CRP levels were higher, despite similar angiographic data just after PCI. Angiographic restenosis at 6 to 8 months after PCI was seen in 10.6% in the lowest tertile, 17.9% in the middle tertile, and 32.0% in the highest tertile (P=0.0007). Conclusions - Increased preprocedural serum CRP levels would predict higher major adverse cardiac events and restenosis rates after sirolimus-eluting stents implantation in patients on hemodialysis.

AB - Background - Percutaneous coronary intervention (PCI) using drug-eluting stents significantly reduces the risk of restenosis in the general population. However, in patients on hemodialysis, adverse cardiac events are frequently seen even if treated with drug-eluting stents. Recent studies suggest that C-reactive protein (CRP) reflects vascular wall inflammation and can predict adverse cardiac events. We evaluated possible prognostic values of CRP on outcomes in patients on hemodialysis undergoing PCI with drug eluting stents. Methods and Results - A total of 167 patients undergoing PCI with sirolimus-eluting stents for stable angina (322 lesions) were enrolled. They were divided into tertiles according to serum CRP levels. We analyzed the incidence of major adverse cardiovascular events including cardiovascular death, nonfatal myocardial infarction, and target lesion revascularization after PCI as well as quantitative coronary angiographic data. The mean follow-up was 31 months (SD, 14). Major adverse cardiac events occurred in 11 patients (19.6%) of the lowest tertile, in 22 patients (39.3%) of the middle tertile, and in 28 patients (50.9%) of the highest tertile during follow-up period (P=0.0009). There was a progressive increase in neointimal growth after sirolimus-eluting stent implantation during follow-up because preprocedural CRP levels were higher, despite similar angiographic data just after PCI. Angiographic restenosis at 6 to 8 months after PCI was seen in 10.6% in the lowest tertile, 17.9% in the middle tertile, and 32.0% in the highest tertile (P=0.0007). Conclusions - Increased preprocedural serum CRP levels would predict higher major adverse cardiac events and restenosis rates after sirolimus-eluting stents implantation in patients on hemodialysis.

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U2 - 10.1161/CIRCINTERVENTIONS.109.889915

DO - 10.1161/CIRCINTERVENTIONS.109.889915

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