Prognostication by inflammation-based score in patients with locally advanced pancreatic cancer treated with chemoradiotherapy

Hiroshi Kurahara, Kosei Maemura, Yuko Mataki, Masahiko Sakoda, Satoshi Iino, Kiyokazu Hiwatashi, Yota Kawasaki, Takaaki Arigami, Sumiya Ishigami, Yuko Kijima, Hiroyuki Shinchi, Sonshin Takao, Shoji Natsugoe

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13 Citations (Scopus)

Abstract

Background An association between inflammatory/immunonutritional status and patient prognosis has been reported in various types of cancer. The aim of this study was to evaluate the utility of inflammatory/immunonutritional factors as therapeutic predictors for patients with locally advanced pancreatic cancer treated with chemoradiotherapy (CRT). Methods Ninety-six patients with histologically proven locally advanced pancreatic adenocarcinoma who underwent CRT were enrolled in this study. We evaluated significance of inflammation-based factors as predictors of therapeutic effect and prognosis. Results The median progression free survival (PFS) and overall survival (OS) of all patients was 10 and 18 months, respectively. A Glasgow prognostic score (GPS) of 2 and plasma fibrinogen levels ≥ 400 mg/dL were independent predictors of poor PFS and OS. A prognostic nutritional index (PNI) ≥ 45 was a predictor of a significantly better reduction rate of the primary tumor. The prognosis between patients with GPS 0/1 and fibrinogen <400 mg/dL, GPS 2 or fibrinogen ≥400 mg/dL, and GPS 2 and fibrinogen ≥400 mg/dL were significantly different. Patients with GPS 2 and/or plasma fibrinogen ≥ 400 mg/dL had significantly higher incidence of metastasis within 6 months after CRT. Conclusions GPS, fibrinogen, PNI are useful therapeutic and prognostic predictors in patients with locally advanced pancreatic cancer treated with CRT.

Original languageEnglish
Pages (from-to)688-693
Number of pages6
JournalPancreatology
Volume15
Issue number6
DOIs
Publication statusPublished - 01-01-2015
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Gastroenterology

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    Kurahara, H., Maemura, K., Mataki, Y., Sakoda, M., Iino, S., Hiwatashi, K., Kawasaki, Y., Arigami, T., Ishigami, S., Kijima, Y., Shinchi, H., Takao, S., & Natsugoe, S. (2015). Prognostication by inflammation-based score in patients with locally advanced pancreatic cancer treated with chemoradiotherapy. Pancreatology, 15(6), 688-693. https://doi.org/10.1016/j.pan.2015.09.015