Progress in molecularly targeted therapies for acute myeloid leukemia

Akihiro Tomita

doi:10.11406/rinketsu.56.130

Progress in molecularly targeted therapies for acute myeloid leukemia

Akihiro Tomita

Research output: Contribution to journal › Article › peer-review

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Abstract

Genetic abnormalities including specific point mutations have recently been confirmed by applying comprehensive genome sequencing analyses. Molecular targeting therapies, which focus on the mutated proteins and over-expressed proteins in acute myeloid leukemia (AML) cells, are now being developed in clinical studies and/or based on in vitro analyses. This manuscript summarizes the genetic abnormalities in AML cells and some of the current molecular targeting therapies including FLT3 inhibitors (e.g. AC220; Quizartinib), Polo like kinase 1 (PLK1) inhibitors (e.g. BI-6727; Volasertib), IDH2 inhibitors (e.g. AG-221), and XPO1 inhibitors (e.g. KPT-330; Selinexor).

Original language	English
Pages (from-to)	130-138
Number of pages	9
Journal	[Rinshō ketsueki] The Japanese journal of clinical hematology
Volume	56
Issue number	2
DOIs	https://doi.org/10.11406/rinketsu.56.130
Publication status	Published - 01-02-2015
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Medicine

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abstract = "Genetic abnormalities including specific point mutations have recently been confirmed by applying comprehensive genome sequencing analyses. Molecular targeting therapies, which focus on the mutated proteins and over-expressed proteins in acute myeloid leukemia (AML) cells, are now being developed in clinical studies and/or based on in vitro analyses. This manuscript summarizes the genetic abnormalities in AML cells and some of the current molecular targeting therapies including FLT3 inhibitors (e.g. AC220; Quizartinib), Polo like kinase 1 (PLK1) inhibitors (e.g. BI-6727; Volasertib), IDH2 inhibitors (e.g. AG-221), and XPO1 inhibitors (e.g. KPT-330; Selinexor). ",

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Progress in molecularly targeted therapies for acute myeloid leukemia

Abstract

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