PROKR2 is associated with methamphetamine dependence in the Japanese population

Taro Kishi, Tsuyoshi Kitajima, Tomoko Tsunoka, Takenori Okumura, Tomo Okochi, Kunihiro Kawashima, Toshiya Inada, Hiroshi Ujike, Mitsuhiko Yamada, Naohisa Uchimura, Ichiro Sora, Masaomi Iyo, Norio Ozaki, Nakao Iwata

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: Many patients with drug addiction are reported to have comorbid mood disorders. One of the suggested pathophysiological mechanisms for mood disorders is disruption of circadian rhythms. Several animal studies have shown that methamphetamine altered the expression of circadian clock molecules in the brain. Therefore, it is possible that mood disorders and drug addiction have common susceptibility genes. Recently, we reported that the prokineticin 2 receptor gene (PROKR2) was associated with mood disorders including major depressive disorder and bipolar disorder in the Japanese population. In the present study, therefore, we conducted an association analysis of tagging SNPs in PROKR2 with Japanese methamphetamine dependence patients. Methods: Using five tagging SNPs in PROKR2, we conducted a genetic association analysis of case-control samples (199 methamphetamine dependence patients and 337 healthy controls). The age and sex of the control subjects did not differ from those of the methamphetamine dependence patients. Results: We detected a significant association between PROKR2 and methamphetamine dependence patients in allele/genotype-wise and haplotype-wise analysis. Conclusion: Our results suggest that PROKR2 may play a role in the pathophysiology of methamphetamine dependence in the Japanese population. However, because we did not perform a mutation scan of PROKR2, a replication study using a larger sample may be required for conclusive results.

Original languageEnglish
Pages (from-to)1033-1036
Number of pages4
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume34
Issue number6
DOIs
Publication statusPublished - 01-08-2010

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Methamphetamine
Mood Disorders
Population
Substance-Related Disorders
Single Nucleotide Polymorphism
Circadian Clocks
Major Depressive Disorder
Circadian Rhythm
Bipolar Disorder
Haplotypes
Genes
Alleles
Genotype
Mutation
Brain

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Biological Psychiatry

Cite this

Kishi, Taro ; Kitajima, Tsuyoshi ; Tsunoka, Tomoko ; Okumura, Takenori ; Okochi, Tomo ; Kawashima, Kunihiro ; Inada, Toshiya ; Ujike, Hiroshi ; Yamada, Mitsuhiko ; Uchimura, Naohisa ; Sora, Ichiro ; Iyo, Masaomi ; Ozaki, Norio ; Iwata, Nakao. / PROKR2 is associated with methamphetamine dependence in the Japanese population. In: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2010 ; Vol. 34, No. 6. pp. 1033-1036.
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abstract = "Background: Many patients with drug addiction are reported to have comorbid mood disorders. One of the suggested pathophysiological mechanisms for mood disorders is disruption of circadian rhythms. Several animal studies have shown that methamphetamine altered the expression of circadian clock molecules in the brain. Therefore, it is possible that mood disorders and drug addiction have common susceptibility genes. Recently, we reported that the prokineticin 2 receptor gene (PROKR2) was associated with mood disorders including major depressive disorder and bipolar disorder in the Japanese population. In the present study, therefore, we conducted an association analysis of tagging SNPs in PROKR2 with Japanese methamphetamine dependence patients. Methods: Using five tagging SNPs in PROKR2, we conducted a genetic association analysis of case-control samples (199 methamphetamine dependence patients and 337 healthy controls). The age and sex of the control subjects did not differ from those of the methamphetamine dependence patients. Results: We detected a significant association between PROKR2 and methamphetamine dependence patients in allele/genotype-wise and haplotype-wise analysis. Conclusion: Our results suggest that PROKR2 may play a role in the pathophysiology of methamphetamine dependence in the Japanese population. However, because we did not perform a mutation scan of PROKR2, a replication study using a larger sample may be required for conclusive results.",
author = "Taro Kishi and Tsuyoshi Kitajima and Tomoko Tsunoka and Takenori Okumura and Tomo Okochi and Kunihiro Kawashima and Toshiya Inada and Hiroshi Ujike and Mitsuhiko Yamada and Naohisa Uchimura and Ichiro Sora and Masaomi Iyo and Norio Ozaki and Nakao Iwata",
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Kishi, T, Kitajima, T, Tsunoka, T, Okumura, T, Okochi, T, Kawashima, K, Inada, T, Ujike, H, Yamada, M, Uchimura, N, Sora, I, Iyo, M, Ozaki, N & Iwata, N 2010, 'PROKR2 is associated with methamphetamine dependence in the Japanese population', Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 34, no. 6, pp. 1033-1036. https://doi.org/10.1016/j.pnpbp.2010.05.018

PROKR2 is associated with methamphetamine dependence in the Japanese population. / Kishi, Taro; Kitajima, Tsuyoshi; Tsunoka, Tomoko; Okumura, Takenori; Okochi, Tomo; Kawashima, Kunihiro; Inada, Toshiya; Ujike, Hiroshi; Yamada, Mitsuhiko; Uchimura, Naohisa; Sora, Ichiro; Iyo, Masaomi; Ozaki, Norio; Iwata, Nakao.

In: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 34, No. 6, 01.08.2010, p. 1033-1036.

Research output: Contribution to journalArticle

TY - JOUR

T1 - PROKR2 is associated with methamphetamine dependence in the Japanese population

AU - Kishi, Taro

AU - Kitajima, Tsuyoshi

AU - Tsunoka, Tomoko

AU - Okumura, Takenori

AU - Okochi, Tomo

AU - Kawashima, Kunihiro

AU - Inada, Toshiya

AU - Ujike, Hiroshi

AU - Yamada, Mitsuhiko

AU - Uchimura, Naohisa

AU - Sora, Ichiro

AU - Iyo, Masaomi

AU - Ozaki, Norio

AU - Iwata, Nakao

PY - 2010/8/1

Y1 - 2010/8/1

N2 - Background: Many patients with drug addiction are reported to have comorbid mood disorders. One of the suggested pathophysiological mechanisms for mood disorders is disruption of circadian rhythms. Several animal studies have shown that methamphetamine altered the expression of circadian clock molecules in the brain. Therefore, it is possible that mood disorders and drug addiction have common susceptibility genes. Recently, we reported that the prokineticin 2 receptor gene (PROKR2) was associated with mood disorders including major depressive disorder and bipolar disorder in the Japanese population. In the present study, therefore, we conducted an association analysis of tagging SNPs in PROKR2 with Japanese methamphetamine dependence patients. Methods: Using five tagging SNPs in PROKR2, we conducted a genetic association analysis of case-control samples (199 methamphetamine dependence patients and 337 healthy controls). The age and sex of the control subjects did not differ from those of the methamphetamine dependence patients. Results: We detected a significant association between PROKR2 and methamphetamine dependence patients in allele/genotype-wise and haplotype-wise analysis. Conclusion: Our results suggest that PROKR2 may play a role in the pathophysiology of methamphetamine dependence in the Japanese population. However, because we did not perform a mutation scan of PROKR2, a replication study using a larger sample may be required for conclusive results.

AB - Background: Many patients with drug addiction are reported to have comorbid mood disorders. One of the suggested pathophysiological mechanisms for mood disorders is disruption of circadian rhythms. Several animal studies have shown that methamphetamine altered the expression of circadian clock molecules in the brain. Therefore, it is possible that mood disorders and drug addiction have common susceptibility genes. Recently, we reported that the prokineticin 2 receptor gene (PROKR2) was associated with mood disorders including major depressive disorder and bipolar disorder in the Japanese population. In the present study, therefore, we conducted an association analysis of tagging SNPs in PROKR2 with Japanese methamphetamine dependence patients. Methods: Using five tagging SNPs in PROKR2, we conducted a genetic association analysis of case-control samples (199 methamphetamine dependence patients and 337 healthy controls). The age and sex of the control subjects did not differ from those of the methamphetamine dependence patients. Results: We detected a significant association between PROKR2 and methamphetamine dependence patients in allele/genotype-wise and haplotype-wise analysis. Conclusion: Our results suggest that PROKR2 may play a role in the pathophysiology of methamphetamine dependence in the Japanese population. However, because we did not perform a mutation scan of PROKR2, a replication study using a larger sample may be required for conclusive results.

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