Prolonged selective neutropenia after allogeneic bone marrow transplantation: Possible effect of presensitization by donor lymphocytes prior to transplant

Masayuki Towatari, Koichi Miyamura, Yoshiki Akatsuka, Kazuhito Yamamoto, Saburo Minami, Yoshihisa Kodera

Research output: Contribution to journalArticlepeer-review

Abstract

Selective neutropenia lasting over five months occurred in a 17-year- old adolescent male who received all allogeneic bone marrow transplantation (BMT) from an HLA-identical sibling for severe aplastic anemia. Bone marrow specimens showed maturation arrest of myeloid precursor cells despite sustained engraftment. Cytogenetic analyses revealed complete donor-type chimerism in hematopoietic cells and mixed lymphoid chimerism. The patient received a second BMT from the same donor following more intensive conditioning, including total body irradiation. neutrophil recovery was rapid and complete donor-type hematopoietic and lymphoid chimerism was observed within three weeks of the second transplant. The present case suggests that prolonged selective neutropenia following BMT is due to residual host- derived immunity which is resistant to the standard immunosuppressive conditioning used prior to BMT for asplastic anemia.

Original languageEnglish
Pages (from-to)513-516
Number of pages4
JournalInternational Journal of Hematology
Volume66
Issue number4
DOIs
Publication statusPublished - 12-1997

All Science Journal Classification (ASJC) codes

  • Hematology

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