Prolonged selective neutropenia after allogeneic bone marrow transplantation

Possible effect of presensitization by donor lymphocytes prior to transplant

Masayuki Towatari, Koichi Miyamura, Yoshiki Akatsuka, Kazuhito Yamamoto, Saburo Minami, Yoshihisa Kodera

Research output: Contribution to journalArticle

Abstract

Selective neutropenia lasting over five months occurred in a 17-year- old adolescent male who received all allogeneic bone marrow transplantation (BMT) from an HLA-identical sibling for severe aplastic anemia. Bone marrow specimens showed maturation arrest of myeloid precursor cells despite sustained engraftment. Cytogenetic analyses revealed complete donor-type chimerism in hematopoietic cells and mixed lymphoid chimerism. The patient received a second BMT from the same donor following more intensive conditioning, including total body irradiation. neutrophil recovery was rapid and complete donor-type hematopoietic and lymphoid chimerism was observed within three weeks of the second transplant. The present case suggests that prolonged selective neutropenia following BMT is due to residual host- derived immunity which is resistant to the standard immunosuppressive conditioning used prior to BMT for asplastic anemia.

Original languageEnglish
Pages (from-to)513-516
Number of pages4
JournalInternational Journal of Hematology
Volume66
Issue number4
Publication statusPublished - 01-12-1997
Externally publishedYes

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Homologous Transplantation
Neutropenia
Bone Marrow Transplantation
Chimerism
Tissue Donors
Lymphocytes
Transplants
Aplastic Anemia
Whole-Body Irradiation
Cytogenetic Analysis
Myeloid Cells
Immunosuppressive Agents
Anemia
Siblings
Immunity
Neutrophils
Bone Marrow
Conditioning (Psychology)

All Science Journal Classification (ASJC) codes

  • Hematology

Cite this

Towatari, Masayuki ; Miyamura, Koichi ; Akatsuka, Yoshiki ; Yamamoto, Kazuhito ; Minami, Saburo ; Kodera, Yoshihisa. / Prolonged selective neutropenia after allogeneic bone marrow transplantation : Possible effect of presensitization by donor lymphocytes prior to transplant. In: International Journal of Hematology. 1997 ; Vol. 66, No. 4. pp. 513-516.
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Prolonged selective neutropenia after allogeneic bone marrow transplantation : Possible effect of presensitization by donor lymphocytes prior to transplant. / Towatari, Masayuki; Miyamura, Koichi; Akatsuka, Yoshiki; Yamamoto, Kazuhito; Minami, Saburo; Kodera, Yoshihisa.

In: International Journal of Hematology, Vol. 66, No. 4, 01.12.1997, p. 513-516.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prolonged selective neutropenia after allogeneic bone marrow transplantation

T2 - Possible effect of presensitization by donor lymphocytes prior to transplant

AU - Towatari, Masayuki

AU - Miyamura, Koichi

AU - Akatsuka, Yoshiki

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AU - Minami, Saburo

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