TY - JOUR
T1 - Prolonged selective neutropenia after allogeneic bone marrow transplantation
T2 - Possible effect of presensitization by donor lymphocytes prior to transplant
AU - Towatari, Masayuki
AU - Miyamura, Koichi
AU - Akatsuka, Yoshiki
AU - Yamamoto, Kazuhito
AU - Minami, Saburo
AU - Kodera, Yoshihisa
PY - 1997/12
Y1 - 1997/12
N2 - Selective neutropenia lasting over five months occurred in a 17-year- old adolescent male who received all allogeneic bone marrow transplantation (BMT) from an HLA-identical sibling for severe aplastic anemia. Bone marrow specimens showed maturation arrest of myeloid precursor cells despite sustained engraftment. Cytogenetic analyses revealed complete donor-type chimerism in hematopoietic cells and mixed lymphoid chimerism. The patient received a second BMT from the same donor following more intensive conditioning, including total body irradiation. neutrophil recovery was rapid and complete donor-type hematopoietic and lymphoid chimerism was observed within three weeks of the second transplant. The present case suggests that prolonged selective neutropenia following BMT is due to residual host- derived immunity which is resistant to the standard immunosuppressive conditioning used prior to BMT for asplastic anemia.
AB - Selective neutropenia lasting over five months occurred in a 17-year- old adolescent male who received all allogeneic bone marrow transplantation (BMT) from an HLA-identical sibling for severe aplastic anemia. Bone marrow specimens showed maturation arrest of myeloid precursor cells despite sustained engraftment. Cytogenetic analyses revealed complete donor-type chimerism in hematopoietic cells and mixed lymphoid chimerism. The patient received a second BMT from the same donor following more intensive conditioning, including total body irradiation. neutrophil recovery was rapid and complete donor-type hematopoietic and lymphoid chimerism was observed within three weeks of the second transplant. The present case suggests that prolonged selective neutropenia following BMT is due to residual host- derived immunity which is resistant to the standard immunosuppressive conditioning used prior to BMT for asplastic anemia.
UR - http://www.scopus.com/inward/record.url?scp=0031404733&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031404733&partnerID=8YFLogxK
U2 - 10.1016/s0925-5710(97)00071-6
DO - 10.1016/s0925-5710(97)00071-6
M3 - Article
C2 - 9479877
AN - SCOPUS:0031404733
SN - 0925-5710
VL - 66
SP - 513
EP - 516
JO - International Journal of Hematology
JF - International Journal of Hematology
IS - 4
ER -