Promising efficacy of the sirolimus-eluting stent in patients with acute myocardial infarction

Tomoko Gochi, Hisashi Umeda, Naoki Yoshida, Hironobu Maekawa, Kosuke Watanabe, Taro Okada, Toshiaki Katoh, Toru Asai, Tomomitsu Tani, Masaki Yokoya, Yoshimasa Murakami, Toyoaki Matsushita, Takeshi Shimizu, Yukio Ozaki, Shinya Hiramitsu, Toyoaki Murohara, Masanori Nomura, Shinichiro Morimoto, Hitoshi Hishida

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objectives. This study investigated the safety and efficacy of sirolimus-eluting stents (SESs) on early and late outcomes in patients with acute myocardial infarction. Methods. A series of 100 consecutive patients (September 2004 to November 2005) with acute myocardial infarction undergoing primary stenting using SES(≤ 24 hr)was compared with 100 consecutive patients (September 2003 to August 2004) treated with bare metal stent (BMS). The frequency of major adverse cardiac events (MACE) and stent thrombosis, and status of ticlopidine administration were assessed at 270 days. Results. The rates of premature discontinuation of ticlopidine (SES group < 3 months: 11%, BMS group < 1 month: 11%, p = NS)and stent thrombosis (SES group: 1%, BMS group: 0%, p = NS)were similar in the two groups. At follow-up, restenosis rate and target vessel revascularization rate were lower in the SES group(4% vs 19%, p< 0.001 and 4% vs 10%, p = 0.149, respectively). Furthermore, the occurrence of MACE at 270 days was significantly less frequent in the SES group compared with the BMS.

Original languageEnglish
Pages (from-to)253-261
Number of pages9
JournalJournal of cardiology
Volume48
Issue number5
Publication statusPublished - 01-12-2006

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Sirolimus
Stents
Myocardial Infarction
Metals
Ticlopidine
Thrombosis
Safety

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Gochi, T., Umeda, H., Yoshida, N., Maekawa, H., Watanabe, K., Okada, T., ... Hishida, H. (2006). Promising efficacy of the sirolimus-eluting stent in patients with acute myocardial infarction. Journal of cardiology, 48(5), 253-261.
Gochi, Tomoko ; Umeda, Hisashi ; Yoshida, Naoki ; Maekawa, Hironobu ; Watanabe, Kosuke ; Okada, Taro ; Katoh, Toshiaki ; Asai, Toru ; Tani, Tomomitsu ; Yokoya, Masaki ; Murakami, Yoshimasa ; Matsushita, Toyoaki ; Shimizu, Takeshi ; Ozaki, Yukio ; Hiramitsu, Shinya ; Murohara, Toyoaki ; Nomura, Masanori ; Morimoto, Shinichiro ; Hishida, Hitoshi. / Promising efficacy of the sirolimus-eluting stent in patients with acute myocardial infarction. In: Journal of cardiology. 2006 ; Vol. 48, No. 5. pp. 253-261.
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abstract = "Objectives. This study investigated the safety and efficacy of sirolimus-eluting stents (SESs) on early and late outcomes in patients with acute myocardial infarction. Methods. A series of 100 consecutive patients (September 2004 to November 2005) with acute myocardial infarction undergoing primary stenting using SES(≤ 24 hr)was compared with 100 consecutive patients (September 2003 to August 2004) treated with bare metal stent (BMS). The frequency of major adverse cardiac events (MACE) and stent thrombosis, and status of ticlopidine administration were assessed at 270 days. Results. The rates of premature discontinuation of ticlopidine (SES group < 3 months: 11{\%}, BMS group < 1 month: 11{\%}, p = NS)and stent thrombosis (SES group: 1{\%}, BMS group: 0{\%}, p = NS)were similar in the two groups. At follow-up, restenosis rate and target vessel revascularization rate were lower in the SES group(4{\%} vs 19{\%}, p< 0.001 and 4{\%} vs 10{\%}, p = 0.149, respectively). Furthermore, the occurrence of MACE at 270 days was significantly less frequent in the SES group compared with the BMS.",
author = "Tomoko Gochi and Hisashi Umeda and Naoki Yoshida and Hironobu Maekawa and Kosuke Watanabe and Taro Okada and Toshiaki Katoh and Toru Asai and Tomomitsu Tani and Masaki Yokoya and Yoshimasa Murakami and Toyoaki Matsushita and Takeshi Shimizu and Yukio Ozaki and Shinya Hiramitsu and Toyoaki Murohara and Masanori Nomura and Shinichiro Morimoto and Hitoshi Hishida",
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Gochi, T, Umeda, H, Yoshida, N, Maekawa, H, Watanabe, K, Okada, T, Katoh, T, Asai, T, Tani, T, Yokoya, M, Murakami, Y, Matsushita, T, Shimizu, T, Ozaki, Y, Hiramitsu, S, Murohara, T, Nomura, M, Morimoto, S & Hishida, H 2006, 'Promising efficacy of the sirolimus-eluting stent in patients with acute myocardial infarction', Journal of cardiology, vol. 48, no. 5, pp. 253-261.

Promising efficacy of the sirolimus-eluting stent in patients with acute myocardial infarction. / Gochi, Tomoko; Umeda, Hisashi; Yoshida, Naoki; Maekawa, Hironobu; Watanabe, Kosuke; Okada, Taro; Katoh, Toshiaki; Asai, Toru; Tani, Tomomitsu; Yokoya, Masaki; Murakami, Yoshimasa; Matsushita, Toyoaki; Shimizu, Takeshi; Ozaki, Yukio; Hiramitsu, Shinya; Murohara, Toyoaki; Nomura, Masanori; Morimoto, Shinichiro; Hishida, Hitoshi.

In: Journal of cardiology, Vol. 48, No. 5, 01.12.2006, p. 253-261.

Research output: Contribution to journalArticle

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T1 - Promising efficacy of the sirolimus-eluting stent in patients with acute myocardial infarction

AU - Gochi, Tomoko

AU - Umeda, Hisashi

AU - Yoshida, Naoki

AU - Maekawa, Hironobu

AU - Watanabe, Kosuke

AU - Okada, Taro

AU - Katoh, Toshiaki

AU - Asai, Toru

AU - Tani, Tomomitsu

AU - Yokoya, Masaki

AU - Murakami, Yoshimasa

AU - Matsushita, Toyoaki

AU - Shimizu, Takeshi

AU - Ozaki, Yukio

AU - Hiramitsu, Shinya

AU - Murohara, Toyoaki

AU - Nomura, Masanori

AU - Morimoto, Shinichiro

AU - Hishida, Hitoshi

PY - 2006/12/1

Y1 - 2006/12/1

N2 - Objectives. This study investigated the safety and efficacy of sirolimus-eluting stents (SESs) on early and late outcomes in patients with acute myocardial infarction. Methods. A series of 100 consecutive patients (September 2004 to November 2005) with acute myocardial infarction undergoing primary stenting using SES(≤ 24 hr)was compared with 100 consecutive patients (September 2003 to August 2004) treated with bare metal stent (BMS). The frequency of major adverse cardiac events (MACE) and stent thrombosis, and status of ticlopidine administration were assessed at 270 days. Results. The rates of premature discontinuation of ticlopidine (SES group < 3 months: 11%, BMS group < 1 month: 11%, p = NS)and stent thrombosis (SES group: 1%, BMS group: 0%, p = NS)were similar in the two groups. At follow-up, restenosis rate and target vessel revascularization rate were lower in the SES group(4% vs 19%, p< 0.001 and 4% vs 10%, p = 0.149, respectively). Furthermore, the occurrence of MACE at 270 days was significantly less frequent in the SES group compared with the BMS.

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Gochi T, Umeda H, Yoshida N, Maekawa H, Watanabe K, Okada T et al. Promising efficacy of the sirolimus-eluting stent in patients with acute myocardial infarction. Journal of cardiology. 2006 Dec 1;48(5):253-261.