Promoter methylation status of multidrug resistance 1 (MDR1) gene in noncancerous gastric mucosa correlates with helicobacter pylori infection and gastric cancer occurrence

Tomomitsu Tahara; Tomoyuki Shibata; Hiromi Yamashita; Daisuke Yoshioka; Ichiro Hirata; Tomiyasu Arisawa

doi:10.3109/07357907.2010.483505

Promoter methylation status of multidrug resistance 1 (MDR1) gene in noncancerous gastric mucosa correlates with helicobacter pylori infection and gastric cancer occurrence

Tomomitsu Tahara, Tomoyuki Shibata, Hiromi Yamashita, Daisuke Yoshioka, Ichiro Hirata, Tomiyasu Arisawa

Gastroenterology

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

We investigated the methylation status of multidrug resistance 1 (MDR1) gene promoter in noncancerous gastric mucosa in relation to gastric cancer (GC) occurrence. Methylation of the MDR1 promoter was estimated in 127 GC and 82 non-GC patients. A significant association was found between higher methylation ratio and occurrence of GC. Higher methylation ratio was also associated with occurrence of GC in both Helicobacter pyloripositive and Helicobacter pylorinegative subjects. Higher MR was also associated with Helicobacter pylori infection. Methylation status of MDR1 gene in noncancerous gastric mucosa would be useful for predicting GC occurrence.

Original language	English
Pages (from-to)	711-716
Number of pages	6
Journal	Cancer Investigation
Volume	28
Issue number	7
DOIs	https://doi.org/10.3109/07357907.2010.483505
Publication status	Published - 07-2010

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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10.3109/07357907.2010.483505

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abstract = "We investigated the methylation status of multidrug resistance 1 (MDR1) gene promoter in noncancerous gastric mucosa in relation to gastric cancer (GC) occurrence. Methylation of the MDR1 promoter was estimated in 127 GC and 82 non-GC patients. A significant association was found between higher methylation ratio and occurrence of GC. Higher methylation ratio was also associated with occurrence of GC in both Helicobacter pyloripositive and Helicobacter pylorinegative subjects. Higher MR was also associated with Helicobacter pylori infection. Methylation status of MDR1 gene in noncancerous gastric mucosa would be useful for predicting GC occurrence.",

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AU - Tahara, Tomomitsu

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AU - Yamashita, Hiromi

AU - Yoshioka, Daisuke

AU - Hirata, Ichiro

AU - Arisawa, Tomiyasu

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Promoter methylation status of multidrug resistance 1 (MDR1) gene in noncancerous gastric mucosa correlates with helicobacter pylori infection and gastric cancer occurrence

Abstract

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