Promoter methylation status of multidrug resistance 1 (MDR1) gene in noncancerous gastric mucosa correlates with helicobacter pylori infection and gastric cancer occurrence

Tomomitsu Tahara, Tomoyuki Shibata, Hiromi Yamashita, Daisuke Yoshioka, Ichiro Hirata, Tomiyasu Arisawa

Research output: Contribution to journalArticle

7 Citations (Scopus)


We investigated the methylation status of multidrug resistance 1 (MDR1) gene promoter in noncancerous gastric mucosa in relation to gastric cancer (GC) occurrence. Methylation of the MDR1 promoter was estimated in 127 GC and 82 non-GC patients. A significant association was found between higher methylation ratio and occurrence of GC. Higher methylation ratio was also associated with occurrence of GC in both Helicobacter pyloripositive and Helicobacter pylorinegative subjects. Higher MR was also associated with Helicobacter pylori infection. Methylation status of MDR1 gene in noncancerous gastric mucosa would be useful for predicting GC occurrence.

Original languageEnglish
Pages (from-to)711-716
Number of pages6
JournalCancer Investigation
Issue number7
Publication statusPublished - 01-07-2010


All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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