Propentofylline improves learning and memory deficits in rats induced by β-amyloid protein-(1-40)

Kiyofumi Yamada, Tomoko Tanaka, Kouji Senzaki, Tsutomu Kameyama, Toshitaka Nabeshima

Research output: Contribution to journalArticle

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Abstract

We have reported that continuous infusion of β-amyloid protein-(1-40) into the cerebral ventricle produces learning and memory deficits in rats. Propentofylline has potent stimulatory effects on nerve growth factor (NGF) synthesis/secretion in mouse astrocytes in vitro and increases cerebral NGF content in aged rats. In the present study, we examined the effects of propentofylline on learning and memory deficits in β-amyloid protein- infused rats. The rats were given propentofylline orally once a day throughout the period of behavioral examination. In the β-amyloid protein- infused rats, spontaneous alternation behavior in a Y-maze, and performance in water maze and passive avoidance tasks were significantly impaired compared to sham-operated rats. Propentofylline prevented these behavioral deficits, but did not change the reduction of the activity of choline acetyltransferase in the hippocampus in the β-amyloid protein-infused rats. These results suggest that propentofylline is useful for the treatment of patients with Alzheimer's disease.

Original languageEnglish
Pages (from-to)15-22
Number of pages8
JournalEuropean Journal of Pharmacology
Volume349
Issue number1
DOIs
Publication statusPublished - 15-05-1998

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Amyloidogenic Proteins
Memory Disorders
Learning
Nerve Growth Factor
Cerebral Ventricles
Choline O-Acetyltransferase
propentofylline
Astrocytes
Hippocampus
Alzheimer Disease
Water

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Yamada, Kiyofumi ; Tanaka, Tomoko ; Senzaki, Kouji ; Kameyama, Tsutomu ; Nabeshima, Toshitaka. / Propentofylline improves learning and memory deficits in rats induced by β-amyloid protein-(1-40). In: European Journal of Pharmacology. 1998 ; Vol. 349, No. 1. pp. 15-22.
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Propentofylline improves learning and memory deficits in rats induced by β-amyloid protein-(1-40). / Yamada, Kiyofumi; Tanaka, Tomoko; Senzaki, Kouji; Kameyama, Tsutomu; Nabeshima, Toshitaka.

In: European Journal of Pharmacology, Vol. 349, No. 1, 15.05.1998, p. 15-22.

Research output: Contribution to journalArticle

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