Proposal for assignment of allele numbers for mobile colistin resistance (mcr) genes

Sally R. Partridge, Vincenzo Di Pilato, Yohei Doi, Michael Feldgarden, Daniel H. Haft, William Klimke, Samir Kumar-Singh, Jian Hua Liu, Surbhi Malhotra-Kumar, Arjun Prasad, Gian Maria Rossolini, Stefan Schwarz, Jianzhong Shen, Timothy Walsh, Yang Wang, Basil Britto Xavier

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The initial report of the mcr-1 (mobile colistin resistance) gene has led to many reports of mcr-1 variants and other mcr genes from different bacterial species originating from human, animal and environmental samples in different geographical locations. Resistance gene nomenclature is complex and unfortunately problems such as different names being used for the same gene/protein or the same name being used for different genes/proteins are not uncommon. Registries exist for some families, such as bla (b-lactamase) genes, but there is as yet no agreed nomenclature scheme for mcr genes. The National Center for Biotechnology Information (NCBI) recently took over assigning bla allele numbers from the longstanding Lahey b-lactamase website and has agreed to do the same for mcr genes. Here, we propose a nomenclature scheme that we hope will be acceptable to researchers in this area and that will reduce future confusion.

Original languageEnglish
Pages (from-to)2625-2630
Number of pages6
JournalJournal of Antimicrobial Chemotherapy
Volume73
Issue number10
DOIs
Publication statusPublished - 01-01-2018

Fingerprint

Colistin
Alleles
Terminology
Genes
Names
Bacterial Genes
Information Centers
Biotechnology
Registries
Proteins
Research Personnel

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Partridge, S. R., Pilato, V. D., Doi, Y., Feldgarden, M., Haft, D. H., Klimke, W., ... Xavier, B. B. (2018). Proposal for assignment of allele numbers for mobile colistin resistance (mcr) genes. Journal of Antimicrobial Chemotherapy, 73(10), 2625-2630. https://doi.org/10.1093/jac/dky262
Partridge, Sally R. ; Pilato, Vincenzo Di ; Doi, Yohei ; Feldgarden, Michael ; Haft, Daniel H. ; Klimke, William ; Kumar-Singh, Samir ; Liu, Jian Hua ; Malhotra-Kumar, Surbhi ; Prasad, Arjun ; Rossolini, Gian Maria ; Schwarz, Stefan ; Shen, Jianzhong ; Walsh, Timothy ; Wang, Yang ; Xavier, Basil Britto. / Proposal for assignment of allele numbers for mobile colistin resistance (mcr) genes. In: Journal of Antimicrobial Chemotherapy. 2018 ; Vol. 73, No. 10. pp. 2625-2630.
@article{ac94bf43a48d472cb643ef740b2c4c32,
title = "Proposal for assignment of allele numbers for mobile colistin resistance (mcr) genes",
abstract = "The initial report of the mcr-1 (mobile colistin resistance) gene has led to many reports of mcr-1 variants and other mcr genes from different bacterial species originating from human, animal and environmental samples in different geographical locations. Resistance gene nomenclature is complex and unfortunately problems such as different names being used for the same gene/protein or the same name being used for different genes/proteins are not uncommon. Registries exist for some families, such as bla (b-lactamase) genes, but there is as yet no agreed nomenclature scheme for mcr genes. The National Center for Biotechnology Information (NCBI) recently took over assigning bla allele numbers from the longstanding Lahey b-lactamase website and has agreed to do the same for mcr genes. Here, we propose a nomenclature scheme that we hope will be acceptable to researchers in this area and that will reduce future confusion.",
author = "Partridge, {Sally R.} and Pilato, {Vincenzo Di} and Yohei Doi and Michael Feldgarden and Haft, {Daniel H.} and William Klimke and Samir Kumar-Singh and Liu, {Jian Hua} and Surbhi Malhotra-Kumar and Arjun Prasad and Rossolini, {Gian Maria} and Stefan Schwarz and Jianzhong Shen and Timothy Walsh and Yang Wang and Xavier, {Basil Britto}",
year = "2018",
month = "1",
day = "1",
doi = "10.1093/jac/dky262",
language = "English",
volume = "73",
pages = "2625--2630",
journal = "Journal of Antimicrobial Chemotherapy",
issn = "0305-7453",
publisher = "Oxford University Press",
number = "10",

}

Partridge, SR, Pilato, VD, Doi, Y, Feldgarden, M, Haft, DH, Klimke, W, Kumar-Singh, S, Liu, JH, Malhotra-Kumar, S, Prasad, A, Rossolini, GM, Schwarz, S, Shen, J, Walsh, T, Wang, Y & Xavier, BB 2018, 'Proposal for assignment of allele numbers for mobile colistin resistance (mcr) genes', Journal of Antimicrobial Chemotherapy, vol. 73, no. 10, pp. 2625-2630. https://doi.org/10.1093/jac/dky262

Proposal for assignment of allele numbers for mobile colistin resistance (mcr) genes. / Partridge, Sally R.; Pilato, Vincenzo Di; Doi, Yohei; Feldgarden, Michael; Haft, Daniel H.; Klimke, William; Kumar-Singh, Samir; Liu, Jian Hua; Malhotra-Kumar, Surbhi; Prasad, Arjun; Rossolini, Gian Maria; Schwarz, Stefan; Shen, Jianzhong; Walsh, Timothy; Wang, Yang; Xavier, Basil Britto.

In: Journal of Antimicrobial Chemotherapy, Vol. 73, No. 10, 01.01.2018, p. 2625-2630.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Proposal for assignment of allele numbers for mobile colistin resistance (mcr) genes

AU - Partridge, Sally R.

AU - Pilato, Vincenzo Di

AU - Doi, Yohei

AU - Feldgarden, Michael

AU - Haft, Daniel H.

AU - Klimke, William

AU - Kumar-Singh, Samir

AU - Liu, Jian Hua

AU - Malhotra-Kumar, Surbhi

AU - Prasad, Arjun

AU - Rossolini, Gian Maria

AU - Schwarz, Stefan

AU - Shen, Jianzhong

AU - Walsh, Timothy

AU - Wang, Yang

AU - Xavier, Basil Britto

PY - 2018/1/1

Y1 - 2018/1/1

N2 - The initial report of the mcr-1 (mobile colistin resistance) gene has led to many reports of mcr-1 variants and other mcr genes from different bacterial species originating from human, animal and environmental samples in different geographical locations. Resistance gene nomenclature is complex and unfortunately problems such as different names being used for the same gene/protein or the same name being used for different genes/proteins are not uncommon. Registries exist for some families, such as bla (b-lactamase) genes, but there is as yet no agreed nomenclature scheme for mcr genes. The National Center for Biotechnology Information (NCBI) recently took over assigning bla allele numbers from the longstanding Lahey b-lactamase website and has agreed to do the same for mcr genes. Here, we propose a nomenclature scheme that we hope will be acceptable to researchers in this area and that will reduce future confusion.

AB - The initial report of the mcr-1 (mobile colistin resistance) gene has led to many reports of mcr-1 variants and other mcr genes from different bacterial species originating from human, animal and environmental samples in different geographical locations. Resistance gene nomenclature is complex and unfortunately problems such as different names being used for the same gene/protein or the same name being used for different genes/proteins are not uncommon. Registries exist for some families, such as bla (b-lactamase) genes, but there is as yet no agreed nomenclature scheme for mcr genes. The National Center for Biotechnology Information (NCBI) recently took over assigning bla allele numbers from the longstanding Lahey b-lactamase website and has agreed to do the same for mcr genes. Here, we propose a nomenclature scheme that we hope will be acceptable to researchers in this area and that will reduce future confusion.

UR - http://www.scopus.com/inward/record.url?scp=85052963733&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85052963733&partnerID=8YFLogxK

U2 - 10.1093/jac/dky262

DO - 10.1093/jac/dky262

M3 - Article

AN - SCOPUS:85052963733

VL - 73

SP - 2625

EP - 2630

JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

SN - 0305-7453

IS - 10

ER -