Proposal for assignment of allele numbers for mobile colistin resistance (mcr) genes

Sally R. Partridge, Vincenzo Di Pilato, Yohei Doi, Michael Feldgarden, Daniel H. Haft, William Klimke, Samir Kumar-Singh, Jian Hua Liu, Surbhi Malhotra-Kumar, Arjun Prasad, Gian Maria Rossolini, Stefan Schwarz, Jianzhong Shen, Timothy Walsh, Yang Wang, Basil Britto Xavier

Research output: Contribution to journalArticlepeer-review

77 Citations (Scopus)


The initial report of the mcr-1 (mobile colistin resistance) gene has led to many reports of mcr-1 variants and other mcr genes from different bacterial species originating from human, animal and environmental samples in different geographical locations. Resistance gene nomenclature is complex and unfortunately problems such as different names being used for the same gene/protein or the same name being used for different genes/proteins are not uncommon. Registries exist for some families, such as bla (b-lactamase) genes, but there is as yet no agreed nomenclature scheme for mcr genes. The National Center for Biotechnology Information (NCBI) recently took over assigning bla allele numbers from the longstanding Lahey b-lactamase website and has agreed to do the same for mcr genes. Here, we propose a nomenclature scheme that we hope will be acceptable to researchers in this area and that will reduce future confusion.

Original languageEnglish
Pages (from-to)2625-2630
Number of pages6
JournalJournal of Antimicrobial Chemotherapy
Issue number10
Publication statusPublished - 01-10-2018
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases


Dive into the research topics of 'Proposal for assignment of allele numbers for mobile colistin resistance (mcr) genes'. Together they form a unique fingerprint.

Cite this