TY - JOUR
T1 - Proposal for assignment of allele numbers for mobile colistin resistance (mcr) genes
AU - Partridge, Sally R.
AU - Pilato, Vincenzo Di
AU - Doi, Yohei
AU - Feldgarden, Michael
AU - Haft, Daniel H.
AU - Klimke, William
AU - Kumar-Singh, Samir
AU - Liu, Jian Hua
AU - Malhotra-Kumar, Surbhi
AU - Prasad, Arjun
AU - Rossolini, Gian Maria
AU - Schwarz, Stefan
AU - Shen, Jianzhong
AU - Walsh, Timothy
AU - Wang, Yang
AU - Xavier, Basil Britto
N1 - Publisher Copyright:
© 2018 Oxford University Press. All Rights Reserved.
PY - 2018/10/1
Y1 - 2018/10/1
N2 - The initial report of the mcr-1 (mobile colistin resistance) gene has led to many reports of mcr-1 variants and other mcr genes from different bacterial species originating from human, animal and environmental samples in different geographical locations. Resistance gene nomenclature is complex and unfortunately problems such as different names being used for the same gene/protein or the same name being used for different genes/proteins are not uncommon. Registries exist for some families, such as bla (b-lactamase) genes, but there is as yet no agreed nomenclature scheme for mcr genes. The National Center for Biotechnology Information (NCBI) recently took over assigning bla allele numbers from the longstanding Lahey b-lactamase website and has agreed to do the same for mcr genes. Here, we propose a nomenclature scheme that we hope will be acceptable to researchers in this area and that will reduce future confusion.
AB - The initial report of the mcr-1 (mobile colistin resistance) gene has led to many reports of mcr-1 variants and other mcr genes from different bacterial species originating from human, animal and environmental samples in different geographical locations. Resistance gene nomenclature is complex and unfortunately problems such as different names being used for the same gene/protein or the same name being used for different genes/proteins are not uncommon. Registries exist for some families, such as bla (b-lactamase) genes, but there is as yet no agreed nomenclature scheme for mcr genes. The National Center for Biotechnology Information (NCBI) recently took over assigning bla allele numbers from the longstanding Lahey b-lactamase website and has agreed to do the same for mcr genes. Here, we propose a nomenclature scheme that we hope will be acceptable to researchers in this area and that will reduce future confusion.
UR - https://www.scopus.com/pages/publications/85052963733
UR - https://www.scopus.com/pages/publications/85052963733#tab=citedBy
U2 - 10.1093/jac/dky262
DO - 10.1093/jac/dky262
M3 - Article
C2 - 30053115
AN - SCOPUS:85052963733
SN - 0305-7453
VL - 73
SP - 2625
EP - 2630
JO - Journal of Antimicrobial Chemotherapy
JF - Journal of Antimicrobial Chemotherapy
IS - 10
ER -
