TY - JOUR
T1 - Proposal for novel histological findings of colorectal liver metastases with preoperative chemotherapy
AU - Ishida, Kazuyuki
AU - Uesugi, Noriyuki
AU - Hasegawa, Yasushi
AU - Sugimoto, Ryo
AU - Takahara, Takeshi
AU - Otsuka, Koki
AU - Nitta, Hiroyuki
AU - Kawasaki, Tomonori
AU - Wakabayashi, Go
AU - Sugai, Tamotsu
N1 - Publisher Copyright:
© 2015 The Authors.
PY - 2015/7/1
Y1 - 2015/7/1
N2 - This study aimed to clarify the histological characteristics related to preoperative chemotherapy for colorectal liver metastases (CRLM). Sixty-three patients with CRLM were divided into two groups: CRLM with chemotherapy (41 cases, group A) and CRLM without chemotherapy (22 cases; surgical treatment alone, group S) to identify the histological differences associated with chemotherapy. In addition, we investigated the effects of combination chemotherapy on the histology of metastatic lesions. Infarct-like necrosis (ILN), three-zonal changes, and cholesterol clefts were more frequent in group A than in group S (P < 0.05). ILN and three-zonal changes were more common in the 5-FU with leucovorin and oxaliplatin (FOLFOX), or 5-FU with leucovorin and irinotecan (FOLFIRI) with or without additional bevacizumab groups than in group S (P < 0.05). Cholesterol clefts in the FOLFOX or FOLFIRI with bevacizumab group and foamy macrophages in the FOLFOX or FOLFIRI group were more common than in group S (P < 0.05). Cases with more than three of the four histological findings-i.e. ILN, three-zonal changes, cholesterol clefts, and foamy macrophages-were more frequent in the FOLFOX or FOLFIRI with or without additional bevacizumab groups than in group S (P < 0.05). We showed histological findings for every representative chemotherapy regimen for CRLM to clarify the effects of preoperative chemotherapy.
AB - This study aimed to clarify the histological characteristics related to preoperative chemotherapy for colorectal liver metastases (CRLM). Sixty-three patients with CRLM were divided into two groups: CRLM with chemotherapy (41 cases, group A) and CRLM without chemotherapy (22 cases; surgical treatment alone, group S) to identify the histological differences associated with chemotherapy. In addition, we investigated the effects of combination chemotherapy on the histology of metastatic lesions. Infarct-like necrosis (ILN), three-zonal changes, and cholesterol clefts were more frequent in group A than in group S (P < 0.05). ILN and three-zonal changes were more common in the 5-FU with leucovorin and oxaliplatin (FOLFOX), or 5-FU with leucovorin and irinotecan (FOLFIRI) with or without additional bevacizumab groups than in group S (P < 0.05). Cholesterol clefts in the FOLFOX or FOLFIRI with bevacizumab group and foamy macrophages in the FOLFOX or FOLFIRI group were more common than in group S (P < 0.05). Cases with more than three of the four histological findings-i.e. ILN, three-zonal changes, cholesterol clefts, and foamy macrophages-were more frequent in the FOLFOX or FOLFIRI with or without additional bevacizumab groups than in group S (P < 0.05). We showed histological findings for every representative chemotherapy regimen for CRLM to clarify the effects of preoperative chemotherapy.
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U2 - 10.1111/pin.12300
DO - 10.1111/pin.12300
M3 - Article
C2 - 25940915
AN - SCOPUS:84933679456
SN - 1320-5463
VL - 65
SP - 367
EP - 373
JO - Pathology International
JF - Pathology International
IS - 7
ER -