Prospective cohort study of the risk of prostate cancer among rotating-shift workers: Findings from the Japan Collaborative Cohort Study

Tatsuhiko Kubo, Kotaro Ozasa, Kazuya Mikami, Kenji Wakai, Yoshihisa Fujino, Yoshiyuki Watanabe, Tsuneharu Miki, Masahiro Nakao, Kyohei Hayashi, Koji Suzuki, Mitsuru Mori, Masakazu Washio, Fumio Sakauchi, Yoshinori Ito, Takesumi Yoshimura, Akiko Tamakoshi

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271 Citations (Scopus)

Abstract

Shift workers have been reported to have an increased risk of some cancers. However, the risk of prostate cancer in shift workers is not known to have been examined previously. This study prospectively examined the association between shift work and risk of prostate cancer incidence among 14,052 working men in Japan enrolled in a large-scale prospective cohort. A baseline survey was conducted between 1988 and 1990. Subjects were asked to indicate the most regular work schedule they had undertaken previously: day work, rotating-shift work, or fixed-night work. During 111,974 person-years, 31 cases of prostate cancer were recorded. The Cox proportional hazards model was used to estimate the risk, with adjustments for age, family history of prostate cancer, study area surveyed, body mass index, smoking, alcohol drinking, job type, physical activity at work, workplace, perceived stress, educational level, and marriage status. Compared with day workers, rotating-shift workers were significantly at risk for prostate cancer (relative risk = 3.0, 95% confidence interval: 1.2, 7.7), whereas fixed-night work was associated with a small and nonsignificant increase in risk. This report is the first known to reveal a significant relation between rotating-shift work and prostate cancer.

Original languageEnglish
Pages (from-to)549-555
Number of pages7
JournalAmerican Journal of Epidemiology
Volume164
Issue number6
DOIs
Publication statusPublished - 01-09-2006

All Science Journal Classification (ASJC) codes

  • Epidemiology

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    Kubo, T., Ozasa, K., Mikami, K., Wakai, K., Fujino, Y., Watanabe, Y., Miki, T., Nakao, M., Hayashi, K., Suzuki, K., Mori, M., Washio, M., Sakauchi, F., Ito, Y., Yoshimura, T., & Tamakoshi, A. (2006). Prospective cohort study of the risk of prostate cancer among rotating-shift workers: Findings from the Japan Collaborative Cohort Study. American Journal of Epidemiology, 164(6), 549-555. https://doi.org/10.1093/aje/kwj232