Prospective study of alcohol consumption and breast cancer risk in Japanese women

Yingsong Lin, Shogo Kikuchi, Koji Tamakoshi, Kenji Wakai, Takaaki Kondo, Yoshimizu Niwa, Hiroshi Yatsuya, Kazuko Nishio, Sadao Suzuki, Shinkan Tokudome, Akio Yamamoto, Hideaki Toyoshima, Akiko Tamakoshi

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Epidemiologic evidence is lacking for the association between alcohol consumption and the risk of breast cancer in Japanese women. We addressed this association in a prospective cohort study with an average follow-up of 7.6 years. At baseline (1988-1990), cohort participants completed a self-administered questionnaire that included alcohol use, reproductive history and hormone use. The women were followed up for breast cancer incidence through December 31, 1997. Cox proportional hazards models were used to calculate relative risks (RRs) and 95% confidence intervals (CIs) for breast cancer incidence and any association with alcohol consumption. During a follow-up of 271,412 person-years, we identified 151 women with breast cancer, of whom 45 were current drinkers and 11 drank ≥15 g of alcohol/day. After adjustment for age and other potential risk factors for breast cancer, the RR for current drinkers was 1.27 (95% CI 0.87-1.84) compared to non-drinkers. Average alcohol intake of <15 g/day did not significantly increase the risk for breast cancer. However, risk was significantly increased for women who consumed >15 g/day of alcohol (RR = 2.93, 95% CI 1.55-5.54). Age at starting drinking and frequency of consumption per week were not significantly associated with breast cancer risk. Our cohort study demonstrated that Japanese women who consume at least a moderate amount of alcohol have an increased risk of breast cancer.

Original languageEnglish
Pages (from-to)779-783
Number of pages5
JournalInternational Journal of Cancer
Volume116
Issue number5
DOIs
Publication statusPublished - 20-09-2005

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Alcohol Drinking
Prospective Studies
Breast Neoplasms
Alcohols
Confidence Intervals
Cohort Studies
Reproductive History
Incidence
Proportional Hazards Models
Drinking
Hormones

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Lin, Y., Kikuchi, S., Tamakoshi, K., Wakai, K., Kondo, T., Niwa, Y., ... Tamakoshi, A. (2005). Prospective study of alcohol consumption and breast cancer risk in Japanese women. International Journal of Cancer, 116(5), 779-783. https://doi.org/10.1002/ijc.20980
Lin, Yingsong ; Kikuchi, Shogo ; Tamakoshi, Koji ; Wakai, Kenji ; Kondo, Takaaki ; Niwa, Yoshimizu ; Yatsuya, Hiroshi ; Nishio, Kazuko ; Suzuki, Sadao ; Tokudome, Shinkan ; Yamamoto, Akio ; Toyoshima, Hideaki ; Tamakoshi, Akiko. / Prospective study of alcohol consumption and breast cancer risk in Japanese women. In: International Journal of Cancer. 2005 ; Vol. 116, No. 5. pp. 779-783.
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abstract = "Epidemiologic evidence is lacking for the association between alcohol consumption and the risk of breast cancer in Japanese women. We addressed this association in a prospective cohort study with an average follow-up of 7.6 years. At baseline (1988-1990), cohort participants completed a self-administered questionnaire that included alcohol use, reproductive history and hormone use. The women were followed up for breast cancer incidence through December 31, 1997. Cox proportional hazards models were used to calculate relative risks (RRs) and 95{\%} confidence intervals (CIs) for breast cancer incidence and any association with alcohol consumption. During a follow-up of 271,412 person-years, we identified 151 women with breast cancer, of whom 45 were current drinkers and 11 drank ≥15 g of alcohol/day. After adjustment for age and other potential risk factors for breast cancer, the RR for current drinkers was 1.27 (95{\%} CI 0.87-1.84) compared to non-drinkers. Average alcohol intake of <15 g/day did not significantly increase the risk for breast cancer. However, risk was significantly increased for women who consumed >15 g/day of alcohol (RR = 2.93, 95{\%} CI 1.55-5.54). Age at starting drinking and frequency of consumption per week were not significantly associated with breast cancer risk. Our cohort study demonstrated that Japanese women who consume at least a moderate amount of alcohol have an increased risk of breast cancer.",
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Lin, Y, Kikuchi, S, Tamakoshi, K, Wakai, K, Kondo, T, Niwa, Y, Yatsuya, H, Nishio, K, Suzuki, S, Tokudome, S, Yamamoto, A, Toyoshima, H & Tamakoshi, A 2005, 'Prospective study of alcohol consumption and breast cancer risk in Japanese women', International Journal of Cancer, vol. 116, no. 5, pp. 779-783. https://doi.org/10.1002/ijc.20980

Prospective study of alcohol consumption and breast cancer risk in Japanese women. / Lin, Yingsong; Kikuchi, Shogo; Tamakoshi, Koji; Wakai, Kenji; Kondo, Takaaki; Niwa, Yoshimizu; Yatsuya, Hiroshi; Nishio, Kazuko; Suzuki, Sadao; Tokudome, Shinkan; Yamamoto, Akio; Toyoshima, Hideaki; Tamakoshi, Akiko.

In: International Journal of Cancer, Vol. 116, No. 5, 20.09.2005, p. 779-783.

Research output: Contribution to journalArticle

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T1 - Prospective study of alcohol consumption and breast cancer risk in Japanese women

AU - Lin, Yingsong

AU - Kikuchi, Shogo

AU - Tamakoshi, Koji

AU - Wakai, Kenji

AU - Kondo, Takaaki

AU - Niwa, Yoshimizu

AU - Yatsuya, Hiroshi

AU - Nishio, Kazuko

AU - Suzuki, Sadao

AU - Tokudome, Shinkan

AU - Yamamoto, Akio

AU - Toyoshima, Hideaki

AU - Tamakoshi, Akiko

PY - 2005/9/20

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N2 - Epidemiologic evidence is lacking for the association between alcohol consumption and the risk of breast cancer in Japanese women. We addressed this association in a prospective cohort study with an average follow-up of 7.6 years. At baseline (1988-1990), cohort participants completed a self-administered questionnaire that included alcohol use, reproductive history and hormone use. The women were followed up for breast cancer incidence through December 31, 1997. Cox proportional hazards models were used to calculate relative risks (RRs) and 95% confidence intervals (CIs) for breast cancer incidence and any association with alcohol consumption. During a follow-up of 271,412 person-years, we identified 151 women with breast cancer, of whom 45 were current drinkers and 11 drank ≥15 g of alcohol/day. After adjustment for age and other potential risk factors for breast cancer, the RR for current drinkers was 1.27 (95% CI 0.87-1.84) compared to non-drinkers. Average alcohol intake of <15 g/day did not significantly increase the risk for breast cancer. However, risk was significantly increased for women who consumed >15 g/day of alcohol (RR = 2.93, 95% CI 1.55-5.54). Age at starting drinking and frequency of consumption per week were not significantly associated with breast cancer risk. Our cohort study demonstrated that Japanese women who consume at least a moderate amount of alcohol have an increased risk of breast cancer.

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