Prospective study of early chronic pancreatitis diagnosed based on the Japanese diagnostic criteria

Atsushi Masamune, Tatsuhide Nabeshima, Kazuhiro Kikuta, Shin Hamada, Eriko Nakano, Kiyoshi Kume, Atsushi Kanno, Ai Sato, Yuichi Tachibana, Osamu Inatomi, Satoshi Yamamoto, Tsukasa Ikeura, Seiji Futagami, Masashi Taguchi, Keiji Hanada, Kyoko Shimizu, Masanobu Kageoka, Tomotaka Saito, Takaaki Eguchi, Kensuke KubotaMamoru Takenaka, Atsushi Mima, Atsushi Irisawa, Tetsuhide Ito, Akira Andoh, Kazuo Inui, Yoshifumi Takeyama, Hiroki Yamaue, Kazuichi Okazaki, Tooru Shimosegawa

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)


Background: Chronic pancreatitis (CP) is a fibro-inflammatory disease of the pancreas. Early diagnosis and intervention, before CP becomes established and irreversible, are essential to improve the long-term outcomes. The world’s first diagnostic criteria for early CP were proposed in Japan in 2009, but their clinical utility remains elusive. This study aimed to clarify whether patients with early CP progress to definite CP. Methods: This is a multicenter, prospective study. Patients diagnosed as having early CP according to the Japanese diagnostic criteria were prospectively followed for 2 years. Clinical profiles including symptoms, drinking and smoking status, laboratory data, imaging findings and treatments were analyzed. Results: Among the 83 patients who completed the 2-year follow-up period, four (4.8%) patients progressed to definite CP. The diagnosis of 48 (57.8%) patients was unchanged, and that of 31 (37.3%) patients was downgraded. All the four progressive patients were male, alcohol-related, smokers (3 current and 1 ever), and continued drinking. Comparison of the clinical profiles between the progression group (n = 4) and non-progression group (n = 79) revealed that etiology (alcohol-related), smoking status and presence of acute pancreatitis episodes were associated with the progression to definite CP. Conclusions: The Japanese diagnostic criteria could identify some patients before the progression to definite CP, while the majority of the patients did not progress. Trial registration number: UMIN000015992.

Original languageEnglish
Pages (from-to)928-935
Number of pages8
JournalJournal of Gastroenterology
Issue number10
Publication statusPublished - 01-10-2019

All Science Journal Classification (ASJC) codes

  • Gastroenterology


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