Prospective study of screening for stomach cancer in Japan

Tetsuya Mizoue, Takesumi Yoshimura, Noritaka Tokui, Yoshiharu Hoshiyama, Hiroshi Yatsuya, Kiyomi Sakata, Takaaki Kondo, Shogo Kikuchi, Hideaki Toyoshima, Norihiko Hayakawa, Akiko Tamakoshi, Yoshiyuki Ohno, Yoshihisa Fujino, Satoshi Kaneko, M. Mori, Y. Motohashi, S. Hisamichi, Y. Nakamura, T. Shimamoto, H. MikamiShuji Hashimoto, Y. Inaba, H. Tanaka, H. Suzuki, H. Shimizu, S. Tokudome, Y. Ito, A. Koizumi, T. Kawamura, Y. Watanabe, M. Nakao, T. Suzuki, T. Hashimoto, T. Nose, K. Fukuda, T. Kitagawa, T. Kuroki, N. Okamoto, T. Ishibashi, H. Shio, K. Tajima, K. Aoki, S. Tominaga, S. Anzai, T. Kawaguchi, K. Nakamura, M. Masaki, S. Kanamori, M. Morimoto, S. Kamiyama, Y. Takizawa, N. Hachiya, K. Kawai, S. Nakagawa, H. Watanabe, M. Kurihara, Y. Komachi, R. Sasaki, M. Sugita, I. Sugimura, T. Tanaka, T. Hirohata, I. Fujimoto, M. Matsuzaki, H. Miyake, M. Murata, S. Morio, H. Yanagawa, S. Watanabe

Research output: Contribution to journalArticle

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Abstract

Although screening for stomach cancer is a widespread community service in Japan, the benefits of the screening program remain unclear. Our study investigated prospectively the relation between participation in stomach-cancer screening during the past 12 months and subsequent deaths. Data was derived from the Japan Collaborative Cohort Study, in which 480 stomach-cancer deaths were identified during an 8-year follow-up period. Cox proportional hazard regression was used to estimate the relative risk of death from stomach cancer and that from other causes while adjusting for potential confounding factors. In men, screening participation was associated significantly with a reduced risk of death from stomach cancer (relative risk [RR] = 0.54; 95% confidence interval [Cl] = 0.41-0.70). The extent of the risk reduction was greater than potential health selection (for deaths other than stomach, RR = 0.71). The adjustment for potential confounding variables, however, attenuated the difference in risk of death (stomach cancer, RR = 0.65; other causes, RR = 0.71). In women, the magnitude of the association between screening participation and death from stomach cancer (RR = 0.74; 95% Cl = 0.52-1.07) was equal to that for deaths from non-stomach cancers (RR = 0.74). Subgroup analysis showed that women with a parental history of stomach cancer had a reduced risk of death from stomach cancer associated with screening (RR = 0.32; 95% Cl = 0.12-0.87). The present results underline the potential for selection bias in observational studies, and thus it remains an open question whether screening for stomach cancer is effective.

Original languageEnglish
Pages (from-to)103-107
Number of pages5
JournalInternational Journal of Cancer
Volume106
Issue number1
DOIs
Publication statusPublished - 10-08-2003

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Stomach Neoplasms
Japan
Prospective Studies
Confounding Factors (Epidemiology)
Selection Bias
Social Welfare
Risk Reduction Behavior
Early Detection of Cancer
Observational Studies
Stomach
Cohort Studies
Confidence Intervals
Health

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Mizoue, T., Yoshimura, T., Tokui, N., Hoshiyama, Y., Yatsuya, H., Sakata, K., ... Watanabe, S. (2003). Prospective study of screening for stomach cancer in Japan. International Journal of Cancer, 106(1), 103-107. https://doi.org/10.1002/ijc.11183
Mizoue, Tetsuya ; Yoshimura, Takesumi ; Tokui, Noritaka ; Hoshiyama, Yoshiharu ; Yatsuya, Hiroshi ; Sakata, Kiyomi ; Kondo, Takaaki ; Kikuchi, Shogo ; Toyoshima, Hideaki ; Hayakawa, Norihiko ; Tamakoshi, Akiko ; Ohno, Yoshiyuki ; Fujino, Yoshihisa ; Kaneko, Satoshi ; Mori, M. ; Motohashi, Y. ; Hisamichi, S. ; Nakamura, Y. ; Shimamoto, T. ; Mikami, H. ; Hashimoto, Shuji ; Inaba, Y. ; Tanaka, H. ; Suzuki, H. ; Shimizu, H. ; Tokudome, S. ; Ito, Y. ; Koizumi, A. ; Kawamura, T. ; Watanabe, Y. ; Nakao, M. ; Suzuki, T. ; Hashimoto, T. ; Nose, T. ; Fukuda, K. ; Kitagawa, T. ; Kuroki, T. ; Okamoto, N. ; Ishibashi, T. ; Shio, H. ; Tajima, K. ; Aoki, K. ; Tominaga, S. ; Anzai, S. ; Kawaguchi, T. ; Nakamura, K. ; Masaki, M. ; Kanamori, S. ; Morimoto, M. ; Kamiyama, S. ; Takizawa, Y. ; Hachiya, N. ; Kawai, K. ; Nakagawa, S. ; Watanabe, H. ; Kurihara, M. ; Komachi, Y. ; Sasaki, R. ; Sugita, M. ; Sugimura, I. ; Tanaka, T. ; Hirohata, T. ; Fujimoto, I. ; Matsuzaki, M. ; Miyake, H. ; Murata, M. ; Morio, S. ; Yanagawa, H. ; Watanabe, S. / Prospective study of screening for stomach cancer in Japan. In: International Journal of Cancer. 2003 ; Vol. 106, No. 1. pp. 103-107.
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abstract = "Although screening for stomach cancer is a widespread community service in Japan, the benefits of the screening program remain unclear. Our study investigated prospectively the relation between participation in stomach-cancer screening during the past 12 months and subsequent deaths. Data was derived from the Japan Collaborative Cohort Study, in which 480 stomach-cancer deaths were identified during an 8-year follow-up period. Cox proportional hazard regression was used to estimate the relative risk of death from stomach cancer and that from other causes while adjusting for potential confounding factors. In men, screening participation was associated significantly with a reduced risk of death from stomach cancer (relative risk [RR] = 0.54; 95{\%} confidence interval [Cl] = 0.41-0.70). The extent of the risk reduction was greater than potential health selection (for deaths other than stomach, RR = 0.71). The adjustment for potential confounding variables, however, attenuated the difference in risk of death (stomach cancer, RR = 0.65; other causes, RR = 0.71). In women, the magnitude of the association between screening participation and death from stomach cancer (RR = 0.74; 95{\%} Cl = 0.52-1.07) was equal to that for deaths from non-stomach cancers (RR = 0.74). Subgroup analysis showed that women with a parental history of stomach cancer had a reduced risk of death from stomach cancer associated with screening (RR = 0.32; 95{\%} Cl = 0.12-0.87). The present results underline the potential for selection bias in observational studies, and thus it remains an open question whether screening for stomach cancer is effective.",
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Mizoue, T, Yoshimura, T, Tokui, N, Hoshiyama, Y, Yatsuya, H, Sakata, K, Kondo, T, Kikuchi, S, Toyoshima, H, Hayakawa, N, Tamakoshi, A, Ohno, Y, Fujino, Y, Kaneko, S, Mori, M, Motohashi, Y, Hisamichi, S, Nakamura, Y, Shimamoto, T, Mikami, H, Hashimoto, S, Inaba, Y, Tanaka, H, Suzuki, H, Shimizu, H, Tokudome, S, Ito, Y, Koizumi, A, Kawamura, T, Watanabe, Y, Nakao, M, Suzuki, T, Hashimoto, T, Nose, T, Fukuda, K, Kitagawa, T, Kuroki, T, Okamoto, N, Ishibashi, T, Shio, H, Tajima, K, Aoki, K, Tominaga, S, Anzai, S, Kawaguchi, T, Nakamura, K, Masaki, M, Kanamori, S, Morimoto, M, Kamiyama, S, Takizawa, Y, Hachiya, N, Kawai, K, Nakagawa, S, Watanabe, H, Kurihara, M, Komachi, Y, Sasaki, R, Sugita, M, Sugimura, I, Tanaka, T, Hirohata, T, Fujimoto, I, Matsuzaki, M, Miyake, H, Murata, M, Morio, S, Yanagawa, H & Watanabe, S 2003, 'Prospective study of screening for stomach cancer in Japan', International Journal of Cancer, vol. 106, no. 1, pp. 103-107. https://doi.org/10.1002/ijc.11183

Prospective study of screening for stomach cancer in Japan. / Mizoue, Tetsuya; Yoshimura, Takesumi; Tokui, Noritaka; Hoshiyama, Yoshiharu; Yatsuya, Hiroshi; Sakata, Kiyomi; Kondo, Takaaki; Kikuchi, Shogo; Toyoshima, Hideaki; Hayakawa, Norihiko; Tamakoshi, Akiko; Ohno, Yoshiyuki; Fujino, Yoshihisa; Kaneko, Satoshi; Mori, M.; Motohashi, Y.; Hisamichi, S.; Nakamura, Y.; Shimamoto, T.; Mikami, H.; Hashimoto, Shuji; Inaba, Y.; Tanaka, H.; Suzuki, H.; Shimizu, H.; Tokudome, S.; Ito, Y.; Koizumi, A.; Kawamura, T.; Watanabe, Y.; Nakao, M.; Suzuki, T.; Hashimoto, T.; Nose, T.; Fukuda, K.; Kitagawa, T.; Kuroki, T.; Okamoto, N.; Ishibashi, T.; Shio, H.; Tajima, K.; Aoki, K.; Tominaga, S.; Anzai, S.; Kawaguchi, T.; Nakamura, K.; Masaki, M.; Kanamori, S.; Morimoto, M.; Kamiyama, S.; Takizawa, Y.; Hachiya, N.; Kawai, K.; Nakagawa, S.; Watanabe, H.; Kurihara, M.; Komachi, Y.; Sasaki, R.; Sugita, M.; Sugimura, I.; Tanaka, T.; Hirohata, T.; Fujimoto, I.; Matsuzaki, M.; Miyake, H.; Murata, M.; Morio, S.; Yanagawa, H.; Watanabe, S.

In: International Journal of Cancer, Vol. 106, No. 1, 10.08.2003, p. 103-107.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prospective study of screening for stomach cancer in Japan

AU - Mizoue, Tetsuya

AU - Yoshimura, Takesumi

AU - Tokui, Noritaka

AU - Hoshiyama, Yoshiharu

AU - Yatsuya, Hiroshi

AU - Sakata, Kiyomi

AU - Kondo, Takaaki

AU - Kikuchi, Shogo

AU - Toyoshima, Hideaki

AU - Hayakawa, Norihiko

AU - Tamakoshi, Akiko

AU - Ohno, Yoshiyuki

AU - Fujino, Yoshihisa

AU - Kaneko, Satoshi

AU - Mori, M.

AU - Motohashi, Y.

AU - Hisamichi, S.

AU - Nakamura, Y.

AU - Shimamoto, T.

AU - Mikami, H.

AU - Hashimoto, Shuji

AU - Inaba, Y.

AU - Tanaka, H.

AU - Suzuki, H.

AU - Shimizu, H.

AU - Tokudome, S.

AU - Ito, Y.

AU - Koizumi, A.

AU - Kawamura, T.

AU - Watanabe, Y.

AU - Nakao, M.

AU - Suzuki, T.

AU - Hashimoto, T.

AU - Nose, T.

AU - Fukuda, K.

AU - Kitagawa, T.

AU - Kuroki, T.

AU - Okamoto, N.

AU - Ishibashi, T.

AU - Shio, H.

AU - Tajima, K.

AU - Aoki, K.

AU - Tominaga, S.

AU - Anzai, S.

AU - Kawaguchi, T.

AU - Nakamura, K.

AU - Masaki, M.

AU - Kanamori, S.

AU - Morimoto, M.

AU - Kamiyama, S.

AU - Takizawa, Y.

AU - Hachiya, N.

AU - Kawai, K.

AU - Nakagawa, S.

AU - Watanabe, H.

AU - Kurihara, M.

AU - Komachi, Y.

AU - Sasaki, R.

AU - Sugita, M.

AU - Sugimura, I.

AU - Tanaka, T.

AU - Hirohata, T.

AU - Fujimoto, I.

AU - Matsuzaki, M.

AU - Miyake, H.

AU - Murata, M.

AU - Morio, S.

AU - Yanagawa, H.

AU - Watanabe, S.

PY - 2003/8/10

Y1 - 2003/8/10

N2 - Although screening for stomach cancer is a widespread community service in Japan, the benefits of the screening program remain unclear. Our study investigated prospectively the relation between participation in stomach-cancer screening during the past 12 months and subsequent deaths. Data was derived from the Japan Collaborative Cohort Study, in which 480 stomach-cancer deaths were identified during an 8-year follow-up period. Cox proportional hazard regression was used to estimate the relative risk of death from stomach cancer and that from other causes while adjusting for potential confounding factors. In men, screening participation was associated significantly with a reduced risk of death from stomach cancer (relative risk [RR] = 0.54; 95% confidence interval [Cl] = 0.41-0.70). The extent of the risk reduction was greater than potential health selection (for deaths other than stomach, RR = 0.71). The adjustment for potential confounding variables, however, attenuated the difference in risk of death (stomach cancer, RR = 0.65; other causes, RR = 0.71). In women, the magnitude of the association between screening participation and death from stomach cancer (RR = 0.74; 95% Cl = 0.52-1.07) was equal to that for deaths from non-stomach cancers (RR = 0.74). Subgroup analysis showed that women with a parental history of stomach cancer had a reduced risk of death from stomach cancer associated with screening (RR = 0.32; 95% Cl = 0.12-0.87). The present results underline the potential for selection bias in observational studies, and thus it remains an open question whether screening for stomach cancer is effective.

AB - Although screening for stomach cancer is a widespread community service in Japan, the benefits of the screening program remain unclear. Our study investigated prospectively the relation between participation in stomach-cancer screening during the past 12 months and subsequent deaths. Data was derived from the Japan Collaborative Cohort Study, in which 480 stomach-cancer deaths were identified during an 8-year follow-up period. Cox proportional hazard regression was used to estimate the relative risk of death from stomach cancer and that from other causes while adjusting for potential confounding factors. In men, screening participation was associated significantly with a reduced risk of death from stomach cancer (relative risk [RR] = 0.54; 95% confidence interval [Cl] = 0.41-0.70). The extent of the risk reduction was greater than potential health selection (for deaths other than stomach, RR = 0.71). The adjustment for potential confounding variables, however, attenuated the difference in risk of death (stomach cancer, RR = 0.65; other causes, RR = 0.71). In women, the magnitude of the association between screening participation and death from stomach cancer (RR = 0.74; 95% Cl = 0.52-1.07) was equal to that for deaths from non-stomach cancers (RR = 0.74). Subgroup analysis showed that women with a parental history of stomach cancer had a reduced risk of death from stomach cancer associated with screening (RR = 0.32; 95% Cl = 0.12-0.87). The present results underline the potential for selection bias in observational studies, and thus it remains an open question whether screening for stomach cancer is effective.

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Mizoue T, Yoshimura T, Tokui N, Hoshiyama Y, Yatsuya H, Sakata K et al. Prospective study of screening for stomach cancer in Japan. International Journal of Cancer. 2003 Aug 10;106(1):103-107. https://doi.org/10.1002/ijc.11183