Prospective Study of seaweed consumption and thyroid cancer incidence in women: The Japan Collaborative Cohort Study

Chaochen Wang, Hiroshi Yatsuya, Enei Ri, Atsuhiko Ota, Koji Tamakoshi, Yoshihisa Fujino, Haruo Mikami, Hiroyasu Iso, Akiko Tamakoshi, Mitsuru Mori, Fumio Sakauchi, Yoshihiro Kaneko, Ichiro Tsuji, Yosikazu Nakamura, Michiko Kurosawa, Yoshiharu Hoshiyama, Naohito Tanabe, Kenji Wakai, Shinkan Tokudome, Koji SuzukiShuji Hashimoto, Shogo Kikuchi, Yasuhiko Wada, Takashi Kawamura, Yoshiyuki Watanabe, Kotaro Ozasa, Tsuneharu Miki, Chigusa Date, Kiyomi Sakata, Yoichi Kurozawa, Takesumi Yoshimura, Akira Shibata, Naoyuki Okamoto, Hideo Shio

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Excess intake of iodine is a suspected risk factor for thyroid cancer. Previous epidemiological research from Japan reported that daily intake of seaweed was associated with a four-fold higher risk in postmenopausal women, whereas others reported a null association. A major source of iodine intake in Japan is from edible seaweeds, and it is reported to be among the highest in the world. We examined the association between seaweed intake frequency and the risk of thyroid cancer in women in the Japan Collaborative Cohort Study followed from 1988 to 2009. Seaweed intake, together with other lifestyle-related information was collected using a self-administered questionnaire at baseline. Seaweed intake frequency was categorized as follows: 1-2 times/week or less, 3-4 times/week, and almost daily. Hazard ratios and the 95% confidence intervals of thyroid cancer incidence according to seaweed intake frequency were estimated using Cox proportional hazards regression. During 447 876 person-years of follow-up (n=35 687), 94 new cases of thyroid cancer were identified. The crude incidence rate was 20.9 per 100 000 personyears. The hazard ratio of thyroid cancer in women who consumed seaweed daily compared with women who ate it 1-2 times/week or less was 1.15 (95% confidence interval: 0.69-1.90, P for trend= 0.59). Further analyses did not indicate any association between seaweed intake and the risk of thyroid cancer on statistically adjusting for potential confounding variables as well as on stratification by menopausal status. The present study did not find an association between seaweed intake and thyroid cancer incidence in premenopausal or in postmenopausal women.

Original languageEnglish
Pages (from-to)239-245
Number of pages7
JournalEuropean Journal of Cancer Prevention
Volume25
Issue number3
DOIs
Publication statusPublished - 13-04-2016

Fingerprint

Seaweed
Thyroid Neoplasms
Japan
Cohort Studies
Prospective Studies
Incidence
Iodine
Confidence Intervals
Confounding Factors (Epidemiology)
Life Style

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

Cite this

Wang, Chaochen ; Yatsuya, Hiroshi ; Ri, Enei ; Ota, Atsuhiko ; Tamakoshi, Koji ; Fujino, Yoshihisa ; Mikami, Haruo ; Iso, Hiroyasu ; Tamakoshi, Akiko ; Mori, Mitsuru ; Sakauchi, Fumio ; Kaneko, Yoshihiro ; Tsuji, Ichiro ; Nakamura, Yosikazu ; Kurosawa, Michiko ; Hoshiyama, Yoshiharu ; Tanabe, Naohito ; Wakai, Kenji ; Tokudome, Shinkan ; Suzuki, Koji ; Hashimoto, Shuji ; Kikuchi, Shogo ; Wada, Yasuhiko ; Kawamura, Takashi ; Watanabe, Yoshiyuki ; Ozasa, Kotaro ; Miki, Tsuneharu ; Date, Chigusa ; Sakata, Kiyomi ; Kurozawa, Yoichi ; Yoshimura, Takesumi ; Shibata, Akira ; Okamoto, Naoyuki ; Shio, Hideo. / Prospective Study of seaweed consumption and thyroid cancer incidence in women : The Japan Collaborative Cohort Study. In: European Journal of Cancer Prevention. 2016 ; Vol. 25, No. 3. pp. 239-245.
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abstract = "Excess intake of iodine is a suspected risk factor for thyroid cancer. Previous epidemiological research from Japan reported that daily intake of seaweed was associated with a four-fold higher risk in postmenopausal women, whereas others reported a null association. A major source of iodine intake in Japan is from edible seaweeds, and it is reported to be among the highest in the world. We examined the association between seaweed intake frequency and the risk of thyroid cancer in women in the Japan Collaborative Cohort Study followed from 1988 to 2009. Seaweed intake, together with other lifestyle-related information was collected using a self-administered questionnaire at baseline. Seaweed intake frequency was categorized as follows: 1-2 times/week or less, 3-4 times/week, and almost daily. Hazard ratios and the 95{\%} confidence intervals of thyroid cancer incidence according to seaweed intake frequency were estimated using Cox proportional hazards regression. During 447 876 person-years of follow-up (n=35 687), 94 new cases of thyroid cancer were identified. The crude incidence rate was 20.9 per 100 000 personyears. The hazard ratio of thyroid cancer in women who consumed seaweed daily compared with women who ate it 1-2 times/week or less was 1.15 (95{\%} confidence interval: 0.69-1.90, P for trend= 0.59). Further analyses did not indicate any association between seaweed intake and the risk of thyroid cancer on statistically adjusting for potential confounding variables as well as on stratification by menopausal status. The present study did not find an association between seaweed intake and thyroid cancer incidence in premenopausal or in postmenopausal women.",
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Wang, C, Yatsuya, H, Ri, E, Ota, A, Tamakoshi, K, Fujino, Y, Mikami, H, Iso, H, Tamakoshi, A, Mori, M, Sakauchi, F, Kaneko, Y, Tsuji, I, Nakamura, Y, Kurosawa, M, Hoshiyama, Y, Tanabe, N, Wakai, K, Tokudome, S, Suzuki, K, Hashimoto, S, Kikuchi, S, Wada, Y, Kawamura, T, Watanabe, Y, Ozasa, K, Miki, T, Date, C, Sakata, K, Kurozawa, Y, Yoshimura, T, Shibata, A, Okamoto, N & Shio, H 2016, 'Prospective Study of seaweed consumption and thyroid cancer incidence in women: The Japan Collaborative Cohort Study', European Journal of Cancer Prevention, vol. 25, no. 3, pp. 239-245. https://doi.org/10.1097/CEJ.0000000000000168

Prospective Study of seaweed consumption and thyroid cancer incidence in women : The Japan Collaborative Cohort Study. / Wang, Chaochen; Yatsuya, Hiroshi; Ri, Enei; Ota, Atsuhiko; Tamakoshi, Koji; Fujino, Yoshihisa; Mikami, Haruo; Iso, Hiroyasu; Tamakoshi, Akiko; Mori, Mitsuru; Sakauchi, Fumio; Kaneko, Yoshihiro; Tsuji, Ichiro; Nakamura, Yosikazu; Kurosawa, Michiko; Hoshiyama, Yoshiharu; Tanabe, Naohito; Wakai, Kenji; Tokudome, Shinkan; Suzuki, Koji; Hashimoto, Shuji; Kikuchi, Shogo; Wada, Yasuhiko; Kawamura, Takashi; Watanabe, Yoshiyuki; Ozasa, Kotaro; Miki, Tsuneharu; Date, Chigusa; Sakata, Kiyomi; Kurozawa, Yoichi; Yoshimura, Takesumi; Shibata, Akira; Okamoto, Naoyuki; Shio, Hideo.

In: European Journal of Cancer Prevention, Vol. 25, No. 3, 13.04.2016, p. 239-245.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prospective Study of seaweed consumption and thyroid cancer incidence in women

T2 - The Japan Collaborative Cohort Study

AU - Wang, Chaochen

AU - Yatsuya, Hiroshi

AU - Ri, Enei

AU - Ota, Atsuhiko

AU - Tamakoshi, Koji

AU - Fujino, Yoshihisa

AU - Mikami, Haruo

AU - Iso, Hiroyasu

AU - Tamakoshi, Akiko

AU - Mori, Mitsuru

AU - Sakauchi, Fumio

AU - Kaneko, Yoshihiro

AU - Tsuji, Ichiro

AU - Nakamura, Yosikazu

AU - Kurosawa, Michiko

AU - Hoshiyama, Yoshiharu

AU - Tanabe, Naohito

AU - Wakai, Kenji

AU - Tokudome, Shinkan

AU - Suzuki, Koji

AU - Hashimoto, Shuji

AU - Kikuchi, Shogo

AU - Wada, Yasuhiko

AU - Kawamura, Takashi

AU - Watanabe, Yoshiyuki

AU - Ozasa, Kotaro

AU - Miki, Tsuneharu

AU - Date, Chigusa

AU - Sakata, Kiyomi

AU - Kurozawa, Yoichi

AU - Yoshimura, Takesumi

AU - Shibata, Akira

AU - Okamoto, Naoyuki

AU - Shio, Hideo

PY - 2016/4/13

Y1 - 2016/4/13

N2 - Excess intake of iodine is a suspected risk factor for thyroid cancer. Previous epidemiological research from Japan reported that daily intake of seaweed was associated with a four-fold higher risk in postmenopausal women, whereas others reported a null association. A major source of iodine intake in Japan is from edible seaweeds, and it is reported to be among the highest in the world. We examined the association between seaweed intake frequency and the risk of thyroid cancer in women in the Japan Collaborative Cohort Study followed from 1988 to 2009. Seaweed intake, together with other lifestyle-related information was collected using a self-administered questionnaire at baseline. Seaweed intake frequency was categorized as follows: 1-2 times/week or less, 3-4 times/week, and almost daily. Hazard ratios and the 95% confidence intervals of thyroid cancer incidence according to seaweed intake frequency were estimated using Cox proportional hazards regression. During 447 876 person-years of follow-up (n=35 687), 94 new cases of thyroid cancer were identified. The crude incidence rate was 20.9 per 100 000 personyears. The hazard ratio of thyroid cancer in women who consumed seaweed daily compared with women who ate it 1-2 times/week or less was 1.15 (95% confidence interval: 0.69-1.90, P for trend= 0.59). Further analyses did not indicate any association between seaweed intake and the risk of thyroid cancer on statistically adjusting for potential confounding variables as well as on stratification by menopausal status. The present study did not find an association between seaweed intake and thyroid cancer incidence in premenopausal or in postmenopausal women.

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