Prospective study on the outcome of patients with hepatocellular carcinoma registered for living donor liver transplantation: How long can they wait?

Shugo Mizuno, Hajime Yokoi, Katsuya Shiraki, Masanobu Usui, Hiroyuki Sakurai, Masami Tabata, Kazushi Sugimoto, Yoshiyuki Takei, Koichiro Yamakado, Kan Takeda, Shinji Uemoto, Shuji Isaji

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Background: In countries where cadaveric organ donation is limited, living donor liver transplantation (LDLT) has been reserved as a rescue option for the patients with uncontrollable hepatocellular carcinoma (HCC). Patients and Methods: Between March 2002 and June 2006, 56 patients with HCC had been registered as a LDLT candidate after HCC cannot be treated conventionally. We compared the survival rates between the patients who underwent LDLT (living donor liver transplantation group: LT, n=29) and those who did not undergo LDLT (no transplantation group: NLT, n=27). In the NLT group, we examined the periods suitable for resection or ablation (from first diagnosis to registration), suitable for LDLT, and unsuitable for LDLT. Results: Even among the patients who did not meet Milan criteria (LT: n=10, NLT: n=16), 1-and 3-year survival rates were significantly higher in the LT group than in the NLT group: 90.0% and 60.0% vs. 75.0% and 8.3%, respectively (P=0.046). In the NLT group, the median periods suitable for resection or ablation, suitable for LDLT, and unsuitable for LDLT were 28.9, 12.2, and 3.5 months, respectively. Conclusions: LDLT is acceptable for the patients who gave up the conventional treatment. Approximately 12 months remain for the LDLT candidates with HCC to decide to undergo it.

Original languageEnglish
Pages (from-to)650-654
Number of pages5
JournalTransplantation
Volume89
Issue number6
DOIs
Publication statusPublished - 01-03-2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Transplantation

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