Prostaglandin E receptor EP1 controls impulsive behavior under stress

Yoko Matsuoka, Tomoyuki Furuyashiki, Kiyofumi Yamada, Taku Nagai, Haruhiko Bito, Yasuhiro Tanaka, Shiho Kitaoka, Fumitaka Ushikubi, Toshitaka Nabeshima, Shuh Narumiya

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Animals under stress take adaptive actions that may lead to various types of behavioral disinhibition. Such behavioral disinhibition, when expressed excessively and impulsively, can result in harm in individuals and cause a problem in our society. We now show that, under social or environmental stress, mice deficient in prostaglandin E receptor subtype EP1 (Ptger1-/-) manifest behavioral disinhibition, including impulsive aggression with defective social interaction, impaired cliff avoidance, and an exaggerated acoustic startle response. This phenotype was reproduced in wild-type mice by administration of an EP1-selective antagonist, whereas administration of an EP1-selective agonist suppressed electric-shock-induced impulsive aggression. Dopamine turnover in the frontal cortex and striatum was increased in Ptger1-/- mice, and administration of dopaminergic antagonists corrected their behavioral phenotype. These results suggest that prostaglandin E2 acts through EP1 to control impulsive behavior under stress, a finding potentially exploitable for development of drugs that attenuate impulsive behavior in humans.

Original languageEnglish
Pages (from-to)16066-16071
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume102
Issue number44
DOIs
Publication statusPublished - 01-11-2005
Externally publishedYes

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Prostaglandin E Receptors
Impulsive Behavior
Receptors, Prostaglandin E, EP1 Subtype
Aggression
Startle Reflex
Phenotype
Dopamine Antagonists
Frontal Lobe
Interpersonal Relations
Dinoprostone
Acoustics
Shock
Dopamine
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • General

Cite this

Matsuoka, Y., Furuyashiki, T., Yamada, K., Nagai, T., Bito, H., Tanaka, Y., ... Narumiya, S. (2005). Prostaglandin E receptor EP1 controls impulsive behavior under stress. Proceedings of the National Academy of Sciences of the United States of America, 102(44), 16066-16071. https://doi.org/10.1073/pnas.0504908102
Matsuoka, Yoko ; Furuyashiki, Tomoyuki ; Yamada, Kiyofumi ; Nagai, Taku ; Bito, Haruhiko ; Tanaka, Yasuhiro ; Kitaoka, Shiho ; Ushikubi, Fumitaka ; Nabeshima, Toshitaka ; Narumiya, Shuh. / Prostaglandin E receptor EP1 controls impulsive behavior under stress. In: Proceedings of the National Academy of Sciences of the United States of America. 2005 ; Vol. 102, No. 44. pp. 16066-16071.
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Matsuoka, Y, Furuyashiki, T, Yamada, K, Nagai, T, Bito, H, Tanaka, Y, Kitaoka, S, Ushikubi, F, Nabeshima, T & Narumiya, S 2005, 'Prostaglandin E receptor EP1 controls impulsive behavior under stress', Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 44, pp. 16066-16071. https://doi.org/10.1073/pnas.0504908102

Prostaglandin E receptor EP1 controls impulsive behavior under stress. / Matsuoka, Yoko; Furuyashiki, Tomoyuki; Yamada, Kiyofumi; Nagai, Taku; Bito, Haruhiko; Tanaka, Yasuhiro; Kitaoka, Shiho; Ushikubi, Fumitaka; Nabeshima, Toshitaka; Narumiya, Shuh.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, No. 44, 01.11.2005, p. 16066-16071.

Research output: Contribution to journalArticle

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