Abstract
Abnormal intracellular signaling molecules in dopamine signal transduction are thought to be associated with the pathophysiology of methamphetamine (METH)-use disorder. A recent study reported that a new intracellular protein, prostate apoptosis response 4 (Par-4), plays a critical role in dopamine 2 receptor signaling. We therefore analyzed the association between the Par-4 gene (PAWR) and METH-use disorder in a Japanese population (191 patients with METH-use disorder and 466 healthy controls). Using the recommended "gene-based" association analysis, we selected five tagging SNPs in PAWR from the HapMap database. No significant allele/genotype-wise or haplotype-wise association was found between PAWR and METH-use disorder. These results suggest that PAWR does not play a major role in METH-use disorders in the Japanese population.
| Original language | English |
|---|---|
| Title of host publication | Drug Addiction |
| Subtitle of host publication | Research Frontiers and Treatment Advances |
| Publisher | Blackwell Publishing Inc. |
| Pages | 83-88 |
| Number of pages | 6 |
| ISBN (Print) | 9781573317184 |
| DOIs | |
| Publication status | Published - 01-01-2008 |
Publication series
| Name | Annals of the New York Academy of Sciences |
|---|---|
| Volume | 1139 |
| ISSN (Print) | 0077-8923 |
| ISSN (Electronic) | 1749-6632 |
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All Science Journal Classification (ASJC) codes
- Neuroscience(all)
- Biochemistry, Genetics and Molecular Biology(all)
- History and Philosophy of Science
Cite this
}
Prostate apoptosis response 4 gene is not associated with methamphetamine-use disorder in the Jpanese population. / Kishi, Taro; Ikeda, Masashi; Kitajima, Tsuyoshi; Yamanouchi, Yoshio; Kinoshita, Yoko; Kawashima, Kunihiro; Inada, Toshiya; Harano, Mutsuo; Komiyama, Tokutaro; Hori, Toru; Yamada, Mitsuhiko; Iyo, Masaomi; Sora, Ichiro; Sekine, Yoshimoto; Ozaki, Norio; Ujike, Hiroshi; Iwata, Nakao.
Drug Addiction: Research Frontiers and Treatment Advances. Blackwell Publishing Inc., 2008. p. 83-88 (Annals of the New York Academy of Sciences; Vol. 1139).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
TY - GEN
T1 - Prostate apoptosis response 4 gene is not associated with methamphetamine-use disorder in the Jpanese population
AU - Kishi, Taro
AU - Ikeda, Masashi
AU - Kitajima, Tsuyoshi
AU - Yamanouchi, Yoshio
AU - Kinoshita, Yoko
AU - Kawashima, Kunihiro
AU - Inada, Toshiya
AU - Harano, Mutsuo
AU - Komiyama, Tokutaro
AU - Hori, Toru
AU - Yamada, Mitsuhiko
AU - Iyo, Masaomi
AU - Sora, Ichiro
AU - Sekine, Yoshimoto
AU - Ozaki, Norio
AU - Ujike, Hiroshi
AU - Iwata, Nakao
PY - 2008/1/1
Y1 - 2008/1/1
N2 - Abnormal intracellular signaling molecules in dopamine signal transduction are thought to be associated with the pathophysiology of methamphetamine (METH)-use disorder. A recent study reported that a new intracellular protein, prostate apoptosis response 4 (Par-4), plays a critical role in dopamine 2 receptor signaling. We therefore analyzed the association between the Par-4 gene (PAWR) and METH-use disorder in a Japanese population (191 patients with METH-use disorder and 466 healthy controls). Using the recommended "gene-based" association analysis, we selected five tagging SNPs in PAWR from the HapMap database. No significant allele/genotype-wise or haplotype-wise association was found between PAWR and METH-use disorder. These results suggest that PAWR does not play a major role in METH-use disorders in the Japanese population.
AB - Abnormal intracellular signaling molecules in dopamine signal transduction are thought to be associated with the pathophysiology of methamphetamine (METH)-use disorder. A recent study reported that a new intracellular protein, prostate apoptosis response 4 (Par-4), plays a critical role in dopamine 2 receptor signaling. We therefore analyzed the association between the Par-4 gene (PAWR) and METH-use disorder in a Japanese population (191 patients with METH-use disorder and 466 healthy controls). Using the recommended "gene-based" association analysis, we selected five tagging SNPs in PAWR from the HapMap database. No significant allele/genotype-wise or haplotype-wise association was found between PAWR and METH-use disorder. These results suggest that PAWR does not play a major role in METH-use disorders in the Japanese population.
UR - http://www.scopus.com/inward/record.url?scp=53549089620&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=53549089620&partnerID=8YFLogxK
U2 - 10.1196/annals.1432.024
DO - 10.1196/annals.1432.024
M3 - Conference contribution
C2 - 18991852
AN - SCOPUS:53549089620
SN - 9781573317184
T3 - Annals of the New York Academy of Sciences
SP - 83
EP - 88
BT - Drug Addiction
PB - Blackwell Publishing Inc.
ER -