Prostate apoptosis response 4 gene is not associated with methamphetamine-use disorder in the Jpanese population

Taro Kishi; Masashi Ikeda; Tsuyoshi Kitajima; Yoshio Yamanouchi; Yoko Kinoshita; Kunihiro Kawashima; Toshiya Inada; Mutsuo Harano; Tokutaro Komiyama; Toru Hori; Mitsuhiko Yamada; Masaomi Iyo; Ichiro Sora; Yoshimoto Sekine; Norio Ozaki; Hiroshi Ujike; Nakao Iwata

doi:10.1196/annals.1432.024

Prostate apoptosis response 4 gene is not associated with methamphetamine-use disorder in the Jpanese population

Taro Kishi, Masashi Ikeda, Tsuyoshi Kitajima, Yoshio Yamanouchi, Yoko Kinoshita, Kunihiro Kawashima, Toshiya Inada, Mutsuo Harano, Tokutaro Komiyama, Toru Hori, Mitsuhiko Yamada, Masaomi Iyo, Ichiro Sora, Yoshimoto Sekine, Norio Ozaki, Hiroshi Ujike, Nakao Iwata

Department of Psychiatry

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

4 Citations (Scopus)

Abstract

Abnormal intracellular signaling molecules in dopamine signal transduction are thought to be associated with the pathophysiology of methamphetamine (METH)-use disorder. A recent study reported that a new intracellular protein, prostate apoptosis response 4 (Par-4), plays a critical role in dopamine 2 receptor signaling. We therefore analyzed the association between the Par-4 gene (PAWR) and METH-use disorder in a Japanese population (191 patients with METH-use disorder and 466 healthy controls). Using the recommended "gene-based" association analysis, we selected five tagging SNPs in PAWR from the HapMap database. No significant allele/genotype-wise or haplotype-wise association was found between PAWR and METH-use disorder. These results suggest that PAWR does not play a major role in METH-use disorders in the Japanese population.

Original language	English
Title of host publication	Drug Addiction
Subtitle of host publication	Research Frontiers and Treatment Advances
Publisher	Blackwell Publishing Inc.
Pages	83-88
Number of pages	6
ISBN (Print)	9781573317184
DOIs	https://doi.org/10.1196/annals.1432.024
Publication status	Published - 10-2008

Publication series

Name	Annals of the New York Academy of Sciences
Volume	1139
ISSN (Print)	0077-8923
ISSN (Electronic)	1749-6632

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All Science Journal Classification (ASJC) codes

Neuroscience(all)
Biochemistry, Genetics and Molecular Biology(all)
History and Philosophy of Science

Cite this

Kishi, T., Ikeda, M., Kitajima, T., Yamanouchi, Y., Kinoshita, Y., Kawashima, K., Inada, T., Harano, M., Komiyama, T., Hori, T., Yamada, M., Iyo, M., Sora, I., Sekine, Y., Ozaki, N., Ujike, H., & Iwata, N. (2008). Prostate apoptosis response 4 gene is not associated with methamphetamine-use disorder in the Jpanese population. In Drug Addiction: Research Frontiers and Treatment Advances (pp. 83-88). (Annals of the New York Academy of Sciences; Vol. 1139). Blackwell Publishing Inc.. https://doi.org/10.1196/annals.1432.024

Kishi, Taro ; Ikeda, Masashi ; Kitajima, Tsuyoshi ; Yamanouchi, Yoshio ; Kinoshita, Yoko ; Kawashima, Kunihiro ; Inada, Toshiya ; Harano, Mutsuo ; Komiyama, Tokutaro ; Hori, Toru ; Yamada, Mitsuhiko ; Iyo, Masaomi ; Sora, Ichiro ; Sekine, Yoshimoto ; Ozaki, Norio ; Ujike, Hiroshi ; Iwata, Nakao. / Prostate apoptosis response 4 gene is not associated with methamphetamine-use disorder in the Jpanese population. Drug Addiction: Research Frontiers and Treatment Advances. Blackwell Publishing Inc., 2008. pp. 83-88 (Annals of the New York Academy of Sciences).

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title = "Prostate apoptosis response 4 gene is not associated with methamphetamine-use disorder in the Jpanese population",

abstract = "Abnormal intracellular signaling molecules in dopamine signal transduction are thought to be associated with the pathophysiology of methamphetamine (METH)-use disorder. A recent study reported that a new intracellular protein, prostate apoptosis response 4 (Par-4), plays a critical role in dopamine 2 receptor signaling. We therefore analyzed the association between the Par-4 gene (PAWR) and METH-use disorder in a Japanese population (191 patients with METH-use disorder and 466 healthy controls). Using the recommended {"}gene-based{"} association analysis, we selected five tagging SNPs in PAWR from the HapMap database. No significant allele/genotype-wise or haplotype-wise association was found between PAWR and METH-use disorder. These results suggest that PAWR does not play a major role in METH-use disorders in the Japanese population.",

author = "Taro Kishi and Masashi Ikeda and Tsuyoshi Kitajima and Yoshio Yamanouchi and Yoko Kinoshita and Kunihiro Kawashima and Toshiya Inada and Mutsuo Harano and Tokutaro Komiyama and Toru Hori and Mitsuhiko Yamada and Masaomi Iyo and Ichiro Sora and Yoshimoto Sekine and Norio Ozaki and Hiroshi Ujike and Nakao Iwata",

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Kishi, T, Ikeda, M , Kitajima, T, Yamanouchi, Y, Kinoshita, Y, Kawashima, K, Inada, T, Harano, M, Komiyama, T, Hori, T, Yamada, M, Iyo, M, Sora, I, Sekine, Y, Ozaki, N, Ujike, H & Iwata, N 2008, Prostate apoptosis response 4 gene is not associated with methamphetamine-use disorder in the Jpanese population. in Drug Addiction: Research Frontiers and Treatment Advances. Annals of the New York Academy of Sciences, vol. 1139, Blackwell Publishing Inc., pp. 83-88. https://doi.org/10.1196/annals.1432.024

Prostate apoptosis response 4 gene is not associated with methamphetamine-use disorder in the Jpanese population. / Kishi, Taro; Ikeda, Masashi ; Kitajima, Tsuyoshi; Yamanouchi, Yoshio; Kinoshita, Yoko; Kawashima, Kunihiro; Inada, Toshiya; Harano, Mutsuo; Komiyama, Tokutaro; Hori, Toru; Yamada, Mitsuhiko; Iyo, Masaomi; Sora, Ichiro; Sekine, Yoshimoto; Ozaki, Norio; Ujike, Hiroshi; Iwata, Nakao.

Drug Addiction: Research Frontiers and Treatment Advances. Blackwell Publishing Inc., 2008. p. 83-88 (Annals of the New York Academy of Sciences; Vol. 1139).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AU - Kishi, Taro

AU - Ikeda, Masashi

AU - Kitajima, Tsuyoshi

AU - Yamanouchi, Yoshio

AU - Kinoshita, Yoko

AU - Kawashima, Kunihiro

AU - Inada, Toshiya

AU - Harano, Mutsuo

AU - Komiyama, Tokutaro

AU - Hori, Toru

AU - Yamada, Mitsuhiko

AU - Iyo, Masaomi

AU - Sora, Ichiro

AU - Sekine, Yoshimoto

AU - Ozaki, Norio

AU - Ujike, Hiroshi

AU - Iwata, Nakao

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N2 - Abnormal intracellular signaling molecules in dopamine signal transduction are thought to be associated with the pathophysiology of methamphetamine (METH)-use disorder. A recent study reported that a new intracellular protein, prostate apoptosis response 4 (Par-4), plays a critical role in dopamine 2 receptor signaling. We therefore analyzed the association between the Par-4 gene (PAWR) and METH-use disorder in a Japanese population (191 patients with METH-use disorder and 466 healthy controls). Using the recommended "gene-based" association analysis, we selected five tagging SNPs in PAWR from the HapMap database. No significant allele/genotype-wise or haplotype-wise association was found between PAWR and METH-use disorder. These results suggest that PAWR does not play a major role in METH-use disorders in the Japanese population.

AB - Abnormal intracellular signaling molecules in dopamine signal transduction are thought to be associated with the pathophysiology of methamphetamine (METH)-use disorder. A recent study reported that a new intracellular protein, prostate apoptosis response 4 (Par-4), plays a critical role in dopamine 2 receptor signaling. We therefore analyzed the association between the Par-4 gene (PAWR) and METH-use disorder in a Japanese population (191 patients with METH-use disorder and 466 healthy controls). Using the recommended "gene-based" association analysis, we selected five tagging SNPs in PAWR from the HapMap database. No significant allele/genotype-wise or haplotype-wise association was found between PAWR and METH-use disorder. These results suggest that PAWR does not play a major role in METH-use disorders in the Japanese population.

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Kishi T, Ikeda M , Kitajima T, Yamanouchi Y, Kinoshita Y, Kawashima K et al. Prostate apoptosis response 4 gene is not associated with methamphetamine-use disorder in the Jpanese population. In Drug Addiction: Research Frontiers and Treatment Advances. Blackwell Publishing Inc. 2008. p. 83-88. (Annals of the New York Academy of Sciences). https://doi.org/10.1196/annals.1432.024

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10.1196/annals.1432.024