Prostate Cancer Risk in Relation to Insulin-like Growth Factor (IGF)-I and IGF-Binding Protein-3

A Nested Case-Control Study in Large Scale Cohort Study in Japan (JACC Study)

Kazuya Mikami, Kotaro Ozasa, Masahiro Nakao, Tsuneharu Miki, Kyohei Hayashi, Yoshiyuki Watanabe, Mitsuru Mori, Fumio Sakauchi, Masakazu Washio, Tatsuhiko Kubo, Koji Suzuki, Kenji Wakai, Kei Nakachi, Kazuo Tajima, Yoshinori Ito, Yutaka Inaba, Akiko Tamakoshi, Mitsuru Mori, Fumio Sakauchi, Yutaka Motohashi & 23 others Ichiro Tsuji, Yosikazu Nakamura, Hiroyasu Iso, Haruo Mikami, Michiko Kurosawa, Yoshiharu Hoshiyama, Naohito Tanabe, Koji Tamakoshi, Shinkan Tokudome, Shuji Hashimoto, Shogo Kikuchi, Yasuhiko Wada, Takashi Kawamura, Yoshiyuki Watanabe, Tsuneharu Miki, Chigusa Date, Kiyomi Sakata, Yoichi Kurozawa, Takesumi Yoshimura, Yoshihisa Fujino, Akira Shibata, Naoyuki Okamoto, Hideo Shio

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

High levels of insulin-like growth factor (IGF)-I are reported to be associated with an increased risk of prostate cancer. On the other hand, the insulin-like growth factor binding protein-3 (IGFBP-3) may decrease the risk. We therefore investigated the influence of serum IGF-I and IGFBP-3 on prostate cancer risk in a casecontrol study nested within a large-scale cohort in Japan (the Japan Collaborative Cohort Study). Information on lifestyles and sera of the subjects were collected in 1988-90. Serum IGF-I, IGF-II and IGFBP-3 were measured in sera stored at -80oC by immuno-radiometric assay. In 13,508 male subjects of the cohort who donated sera, 40 cases and 120 controls (1:3 matched with age and survey area) were identified. Ages of the cases ranged from 59 to 79 years, with a mean of 69.8. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated for the highest and middle tertiles compared with the lowest in controls using a conditional logistic model. Nonadjusted ORs for the highest tertiles were 0.99 (95% CI, 0.34-2.91) for IGF-I (trend-P = 0.60), 1.91 (95% CI, 0.68-5.38) for IGFBP-3 (trend-P = 0.23), 1.73 (95% CI, 0.69-3.47) for IGF-II (trend-P = 0.23), and 0.67 (95% CI, 0.26-1.76) for the IGF-I/IGBP-3 ratio (trend-P = 0.83). Serum levels of IGF-I, IGF-II, IGFBP-3, or IGF-I/IGFBP-3 ratio were thus not thought to be associated with risk of prostate cancer.

Original languageEnglish
Pages (from-to)57-62
Number of pages6
JournalAsian Pacific Journal of Cancer Prevention
Volume10
Issue numberSUPPL.1
Publication statusPublished - 05-12-2009

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Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor I
Case-Control Studies
Prostatic Neoplasms
Japan
Cohort Studies
Insulin-Like Growth Factor II
Confidence Intervals
Serum
Odds Ratio
Life Style
Logistic Models

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

Cite this

Mikami, Kazuya ; Ozasa, Kotaro ; Nakao, Masahiro ; Miki, Tsuneharu ; Hayashi, Kyohei ; Watanabe, Yoshiyuki ; Mori, Mitsuru ; Sakauchi, Fumio ; Washio, Masakazu ; Kubo, Tatsuhiko ; Suzuki, Koji ; Wakai, Kenji ; Nakachi, Kei ; Tajima, Kazuo ; Ito, Yoshinori ; Inaba, Yutaka ; Tamakoshi, Akiko ; Mori, Mitsuru ; Sakauchi, Fumio ; Motohashi, Yutaka ; Tsuji, Ichiro ; Nakamura, Yosikazu ; Iso, Hiroyasu ; Mikami, Haruo ; Kurosawa, Michiko ; Hoshiyama, Yoshiharu ; Tanabe, Naohito ; Tamakoshi, Koji ; Tokudome, Shinkan ; Hashimoto, Shuji ; Kikuchi, Shogo ; Wada, Yasuhiko ; Kawamura, Takashi ; Watanabe, Yoshiyuki ; Miki, Tsuneharu ; Date, Chigusa ; Sakata, Kiyomi ; Kurozawa, Yoichi ; Yoshimura, Takesumi ; Fujino, Yoshihisa ; Shibata, Akira ; Okamoto, Naoyuki ; Shio, Hideo. / Prostate Cancer Risk in Relation to Insulin-like Growth Factor (IGF)-I and IGF-Binding Protein-3 : A Nested Case-Control Study in Large Scale Cohort Study in Japan (JACC Study). In: Asian Pacific Journal of Cancer Prevention. 2009 ; Vol. 10, No. SUPPL.1. pp. 57-62.
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title = "Prostate Cancer Risk in Relation to Insulin-like Growth Factor (IGF)-I and IGF-Binding Protein-3: A Nested Case-Control Study in Large Scale Cohort Study in Japan (JACC Study)",
abstract = "High levels of insulin-like growth factor (IGF)-I are reported to be associated with an increased risk of prostate cancer. On the other hand, the insulin-like growth factor binding protein-3 (IGFBP-3) may decrease the risk. We therefore investigated the influence of serum IGF-I and IGFBP-3 on prostate cancer risk in a casecontrol study nested within a large-scale cohort in Japan (the Japan Collaborative Cohort Study). Information on lifestyles and sera of the subjects were collected in 1988-90. Serum IGF-I, IGF-II and IGFBP-3 were measured in sera stored at -80oC by immuno-radiometric assay. In 13,508 male subjects of the cohort who donated sera, 40 cases and 120 controls (1:3 matched with age and survey area) were identified. Ages of the cases ranged from 59 to 79 years, with a mean of 69.8. Odds ratios (ORs) and 95{\%} confidence intervals (CIs) were estimated for the highest and middle tertiles compared with the lowest in controls using a conditional logistic model. Nonadjusted ORs for the highest tertiles were 0.99 (95{\%} CI, 0.34-2.91) for IGF-I (trend-P = 0.60), 1.91 (95{\%} CI, 0.68-5.38) for IGFBP-3 (trend-P = 0.23), 1.73 (95{\%} CI, 0.69-3.47) for IGF-II (trend-P = 0.23), and 0.67 (95{\%} CI, 0.26-1.76) for the IGF-I/IGBP-3 ratio (trend-P = 0.83). Serum levels of IGF-I, IGF-II, IGFBP-3, or IGF-I/IGFBP-3 ratio were thus not thought to be associated with risk of prostate cancer.",
author = "Kazuya Mikami and Kotaro Ozasa and Masahiro Nakao and Tsuneharu Miki and Kyohei Hayashi and Yoshiyuki Watanabe and Mitsuru Mori and Fumio Sakauchi and Masakazu Washio and Tatsuhiko Kubo and Koji Suzuki and Kenji Wakai and Kei Nakachi and Kazuo Tajima and Yoshinori Ito and Yutaka Inaba and Akiko Tamakoshi and Mitsuru Mori and Fumio Sakauchi and Yutaka Motohashi and Ichiro Tsuji and Yosikazu Nakamura and Hiroyasu Iso and Haruo Mikami and Michiko Kurosawa and Yoshiharu Hoshiyama and Naohito Tanabe and Koji Tamakoshi and Shinkan Tokudome and Shuji Hashimoto and Shogo Kikuchi and Yasuhiko Wada and Takashi Kawamura and Yoshiyuki Watanabe and Tsuneharu Miki and Chigusa Date and Kiyomi Sakata and Yoichi Kurozawa and Takesumi Yoshimura and Yoshihisa Fujino and Akira Shibata and Naoyuki Okamoto and Hideo Shio",
year = "2009",
month = "12",
day = "5",
language = "English",
volume = "10",
pages = "57--62",
journal = "Asian Pacific Journal of Cancer Prevention",
issn = "1513-7368",
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Mikami, K, Ozasa, K, Nakao, M, Miki, T, Hayashi, K, Watanabe, Y, Mori, M, Sakauchi, F, Washio, M, Kubo, T, Suzuki, K, Wakai, K, Nakachi, K, Tajima, K, Ito, Y, Inaba, Y, Tamakoshi, A, Mori, M, Sakauchi, F, Motohashi, Y, Tsuji, I, Nakamura, Y, Iso, H, Mikami, H, Kurosawa, M, Hoshiyama, Y, Tanabe, N, Tamakoshi, K, Tokudome, S, Hashimoto, S, Kikuchi, S, Wada, Y, Kawamura, T, Watanabe, Y, Miki, T, Date, C, Sakata, K, Kurozawa, Y, Yoshimura, T, Fujino, Y, Shibata, A, Okamoto, N & Shio, H 2009, 'Prostate Cancer Risk in Relation to Insulin-like Growth Factor (IGF)-I and IGF-Binding Protein-3: A Nested Case-Control Study in Large Scale Cohort Study in Japan (JACC Study)', Asian Pacific Journal of Cancer Prevention, vol. 10, no. SUPPL.1, pp. 57-62.

Prostate Cancer Risk in Relation to Insulin-like Growth Factor (IGF)-I and IGF-Binding Protein-3 : A Nested Case-Control Study in Large Scale Cohort Study in Japan (JACC Study). / Mikami, Kazuya; Ozasa, Kotaro; Nakao, Masahiro; Miki, Tsuneharu; Hayashi, Kyohei; Watanabe, Yoshiyuki; Mori, Mitsuru; Sakauchi, Fumio; Washio, Masakazu; Kubo, Tatsuhiko; Suzuki, Koji; Wakai, Kenji; Nakachi, Kei; Tajima, Kazuo; Ito, Yoshinori; Inaba, Yutaka; Tamakoshi, Akiko; Mori, Mitsuru; Sakauchi, Fumio; Motohashi, Yutaka; Tsuji, Ichiro; Nakamura, Yosikazu; Iso, Hiroyasu; Mikami, Haruo; Kurosawa, Michiko; Hoshiyama, Yoshiharu; Tanabe, Naohito; Tamakoshi, Koji; Tokudome, Shinkan; Hashimoto, Shuji; Kikuchi, Shogo; Wada, Yasuhiko; Kawamura, Takashi; Watanabe, Yoshiyuki; Miki, Tsuneharu; Date, Chigusa; Sakata, Kiyomi; Kurozawa, Yoichi; Yoshimura, Takesumi; Fujino, Yoshihisa; Shibata, Akira; Okamoto, Naoyuki; Shio, Hideo.

In: Asian Pacific Journal of Cancer Prevention, Vol. 10, No. SUPPL.1, 05.12.2009, p. 57-62.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prostate Cancer Risk in Relation to Insulin-like Growth Factor (IGF)-I and IGF-Binding Protein-3

T2 - A Nested Case-Control Study in Large Scale Cohort Study in Japan (JACC Study)

AU - Mikami, Kazuya

AU - Ozasa, Kotaro

AU - Nakao, Masahiro

AU - Miki, Tsuneharu

AU - Hayashi, Kyohei

AU - Watanabe, Yoshiyuki

AU - Mori, Mitsuru

AU - Sakauchi, Fumio

AU - Washio, Masakazu

AU - Kubo, Tatsuhiko

AU - Suzuki, Koji

AU - Wakai, Kenji

AU - Nakachi, Kei

AU - Tajima, Kazuo

AU - Ito, Yoshinori

AU - Inaba, Yutaka

AU - Tamakoshi, Akiko

AU - Mori, Mitsuru

AU - Sakauchi, Fumio

AU - Motohashi, Yutaka

AU - Tsuji, Ichiro

AU - Nakamura, Yosikazu

AU - Iso, Hiroyasu

AU - Mikami, Haruo

AU - Kurosawa, Michiko

AU - Hoshiyama, Yoshiharu

AU - Tanabe, Naohito

AU - Tamakoshi, Koji

AU - Tokudome, Shinkan

AU - Hashimoto, Shuji

AU - Kikuchi, Shogo

AU - Wada, Yasuhiko

AU - Kawamura, Takashi

AU - Watanabe, Yoshiyuki

AU - Miki, Tsuneharu

AU - Date, Chigusa

AU - Sakata, Kiyomi

AU - Kurozawa, Yoichi

AU - Yoshimura, Takesumi

AU - Fujino, Yoshihisa

AU - Shibata, Akira

AU - Okamoto, Naoyuki

AU - Shio, Hideo

PY - 2009/12/5

Y1 - 2009/12/5

N2 - High levels of insulin-like growth factor (IGF)-I are reported to be associated with an increased risk of prostate cancer. On the other hand, the insulin-like growth factor binding protein-3 (IGFBP-3) may decrease the risk. We therefore investigated the influence of serum IGF-I and IGFBP-3 on prostate cancer risk in a casecontrol study nested within a large-scale cohort in Japan (the Japan Collaborative Cohort Study). Information on lifestyles and sera of the subjects were collected in 1988-90. Serum IGF-I, IGF-II and IGFBP-3 were measured in sera stored at -80oC by immuno-radiometric assay. In 13,508 male subjects of the cohort who donated sera, 40 cases and 120 controls (1:3 matched with age and survey area) were identified. Ages of the cases ranged from 59 to 79 years, with a mean of 69.8. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated for the highest and middle tertiles compared with the lowest in controls using a conditional logistic model. Nonadjusted ORs for the highest tertiles were 0.99 (95% CI, 0.34-2.91) for IGF-I (trend-P = 0.60), 1.91 (95% CI, 0.68-5.38) for IGFBP-3 (trend-P = 0.23), 1.73 (95% CI, 0.69-3.47) for IGF-II (trend-P = 0.23), and 0.67 (95% CI, 0.26-1.76) for the IGF-I/IGBP-3 ratio (trend-P = 0.83). Serum levels of IGF-I, IGF-II, IGFBP-3, or IGF-I/IGFBP-3 ratio were thus not thought to be associated with risk of prostate cancer.

AB - High levels of insulin-like growth factor (IGF)-I are reported to be associated with an increased risk of prostate cancer. On the other hand, the insulin-like growth factor binding protein-3 (IGFBP-3) may decrease the risk. We therefore investigated the influence of serum IGF-I and IGFBP-3 on prostate cancer risk in a casecontrol study nested within a large-scale cohort in Japan (the Japan Collaborative Cohort Study). Information on lifestyles and sera of the subjects were collected in 1988-90. Serum IGF-I, IGF-II and IGFBP-3 were measured in sera stored at -80oC by immuno-radiometric assay. In 13,508 male subjects of the cohort who donated sera, 40 cases and 120 controls (1:3 matched with age and survey area) were identified. Ages of the cases ranged from 59 to 79 years, with a mean of 69.8. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated for the highest and middle tertiles compared with the lowest in controls using a conditional logistic model. Nonadjusted ORs for the highest tertiles were 0.99 (95% CI, 0.34-2.91) for IGF-I (trend-P = 0.60), 1.91 (95% CI, 0.68-5.38) for IGFBP-3 (trend-P = 0.23), 1.73 (95% CI, 0.69-3.47) for IGF-II (trend-P = 0.23), and 0.67 (95% CI, 0.26-1.76) for the IGF-I/IGBP-3 ratio (trend-P = 0.83). Serum levels of IGF-I, IGF-II, IGFBP-3, or IGF-I/IGFBP-3 ratio were thus not thought to be associated with risk of prostate cancer.

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