Protective effect of hyperpigmented skin on UV-mediated cutaneous cancer development

Masashi Kato; Nobutaka Ohgami; Yoshiyuki Kawamoto; Toyonori Tsuzuki; Khaled Hossain; Takeshi Yanagishita; Yuichiro Ohshima; Hideo Tsuboi; Osamu Yamanoshita; Yoshinari Matsumoto; Masahide Takahashi; Izumi Nakashima

doi:10.1038/sj.jid.5700659

Protective effect of hyperpigmented skin on UV-mediated cutaneous cancer development

Masashi Kato, Nobutaka Ohgami, Yoshiyuki Kawamoto, Toyonori Tsuzuki, Khaled Hossain, Takeshi Yanagishita, Yuichiro Ohshima, Hideo Tsuboi, Osamu Yamanoshita, Yoshinari Matsumoto, Masahide Takahashi, Izumi Nakashima

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19 Citations (Scopus)

Abstract

Recently, we crossed an original haired RET-transgenic mouse of line 242 with a hairless mouse and established a hairless RET-(HL/RET)-transgenic mouse line (242-hr/hr) with hyperpigmented skin but no tumors. In this study, we examined the effect of hyperpigmented skin in HL/RET-transgenic mice on UV irradiation-mediated cutaneous cancer development. UV irradiation to this mouse line never induced melanoma despite the presence of melanoma-inducible transgenic RET oncogenes. On the contrary, the hyperpigmented skin efficiently protected UV-mediated squamous carcinoma development in the skin. Probably underlying this result, hyperpigmentation protected the skin from damage and blocked the accompanying signal transduction for tyrosine phosphorylation of multiple cellular proteins and activation/phosphorylation of extracellular signal-regulated, c-Jun N-terminal, and p38 kinases. Thus, we demonstrated hyperpigmentation-mediated in vivo protection against UV irradiation-induced skin cancer.

Original language	English
Pages (from-to)	1244-1249
Number of pages	6
Journal	Journal of Investigative Dermatology
Volume	127
Issue number	5
DOIs	https://doi.org/10.1038/sj.jid.5700659
Publication status	Published - 05-2007

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Dermatology
Cell Biology

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Kato, M., Ohgami, N., Kawamoto, Y., Tsuzuki, T., Hossain, K., Yanagishita, T., Ohshima, Y., Tsuboi, H., Yamanoshita, O., Matsumoto, Y., Takahashi, M., & Nakashima, I. (2007). Protective effect of hyperpigmented skin on UV-mediated cutaneous cancer development. Journal of Investigative Dermatology, 127(5), 1244-1249. https://doi.org/10.1038/sj.jid.5700659

Kato, Masashi ; Ohgami, Nobutaka ; Kawamoto, Yoshiyuki ; Tsuzuki, Toyonori ; Hossain, Khaled ; Yanagishita, Takeshi ; Ohshima, Yuichiro ; Tsuboi, Hideo ; Yamanoshita, Osamu ; Matsumoto, Yoshinari ; Takahashi, Masahide ; Nakashima, Izumi. / Protective effect of hyperpigmented skin on UV-mediated cutaneous cancer development. In: Journal of Investigative Dermatology. 2007 ; Vol. 127, No. 5. pp. 1244-1249.

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abstract = "Recently, we crossed an original haired RET-transgenic mouse of line 242 with a hairless mouse and established a hairless RET-(HL/RET)-transgenic mouse line (242-hr/hr) with hyperpigmented skin but no tumors. In this study, we examined the effect of hyperpigmented skin in HL/RET-transgenic mice on UV irradiation-mediated cutaneous cancer development. UV irradiation to this mouse line never induced melanoma despite the presence of melanoma-inducible transgenic RET oncogenes. On the contrary, the hyperpigmented skin efficiently protected UV-mediated squamous carcinoma development in the skin. Probably underlying this result, hyperpigmentation protected the skin from damage and blocked the accompanying signal transduction for tyrosine phosphorylation of multiple cellular proteins and activation/phosphorylation of extracellular signal-regulated, c-Jun N-terminal, and p38 kinases. Thus, we demonstrated hyperpigmentation-mediated in vivo protection against UV irradiation-induced skin cancer.",

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Protective effect of hyperpigmented skin on UV-mediated cutaneous cancer development. / Kato, Masashi; Ohgami, Nobutaka; Kawamoto, Yoshiyuki; Tsuzuki, Toyonori; Hossain, Khaled; Yanagishita, Takeshi; Ohshima, Yuichiro; Tsuboi, Hideo; Yamanoshita, Osamu; Matsumoto, Yoshinari; Takahashi, Masahide; Nakashima, Izumi.

In: Journal of Investigative Dermatology, Vol. 127, No. 5, 05.2007, p. 1244-1249.

Research output: Contribution to journal › Article

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AU - Kato, Masashi

AU - Ohgami, Nobutaka

AU - Kawamoto, Yoshiyuki

AU - Tsuzuki, Toyonori

AU - Hossain, Khaled

AU - Yanagishita, Takeshi

AU - Ohshima, Yuichiro

AU - Tsuboi, Hideo

AU - Yamanoshita, Osamu

AU - Matsumoto, Yoshinari

AU - Takahashi, Masahide

AU - Nakashima, Izumi

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