Protective effect of sivelestat sodium (Eraspol®) on postoperative lung dysfunction in patients with type A acute aortic dissection: A pilot study

Toshiya Nishibe, Y. Kondo, A. Muto, A. Dardik, Y. Ohara, M. Kainuma, K. Takeda

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Aim. The authors evaluated the protective effect of sivelestat sodium on postoperative lung dysfunction in patients with type A acute aortic dissection who underwent aortic arch surgery with cardiopulmonary bypass (CPB) under deep hypothermia with circulatory arrest (DHCA). Methods. Twelve patients with type A acute aortic dissection who underwent aortic arch replacement under CPB with DHCA and were pretreated with or without sivelestat sodium (sivelestat group, N.=7 patients; control group, N.=5 patients) were observed. The ratio of arterial oxygen tension to inspired oxygen fraction (P/F ratio) was measured as a parameter of pulmonary function before and after operation. The number of white blood cells was also counted as an index of inflammatory reaction before and after the operation. Results. The P/F ratio decreased significantly after operation in the control group. However, the P/F ratio was unchanged between before and after operation in the sivelestat group. The number of white blood cells tended to increase after operation in the control group, whereas it decreased significantly after operation in the sivelestat group. Conclusion. The present study demonstrated the protective effect of sivelestat sodium on postoperative lung injury in patients with acute type A aortic dissection undergoing aortic arch surgery under CPB with DHCA.

Original languageEnglish
Pages (from-to)627-631
Number of pages5
JournalJournal of Cardiovascular Surgery
Volume49
Issue number5
Publication statusPublished - 10-2008

All Science Journal Classification (ASJC) codes

  • Surgery
  • Cardiology and Cardiovascular Medicine

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