Protective effect of wogonin on endotoxin-induced lethal shock in D-galactosamine-sensitized mice

M. Van Dien, K. Takahashi, M. M. Mu, N. Koide, T. Sugiyama, I. Mori, T. Yoshida, T. Yokochi

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31 Citations (Scopus)

Abstract

The effects of wogonin, a major flavonoid from Scutellaria baicalensis Georgi, on lipopolysaccharide (LPS)-induced lethal shock in mice was investigated. Wogonin pretreatment prevented the lethal shock in mice injected with D-galactosamine (D-GaIN) and LPS, but not in mice injected with a high dose of LPS. Wogonin definitely inhibited the hepatic injury in mice injected with D-GaIN, and LPS and reduced the level of circulating tumor necrosis factor (TNF)-α. The reduction was more marked in mice injected with D-GaIN and LPS compared with that in mice injected with a high dose of LPS. Wogonin pretreatment did not inhibit the lipid peroxidation in mice receiving either D-GaIN and LPS or a high dose of LPS. Wogonin inhibited the in vitro production of TNF-α and nitric oxide in LPS-stimulated RAW 264.7 cells. The mechanism of the protective effect of wogonin on the lethal shock in mice injected with D-GaIN and LPS is discussed.

Original languageEnglish
Pages (from-to)751-756
Number of pages6
JournalMICROBIOLOGY and IMMUNOLOGY
Volume45
Issue number11
DOIs
Publication statusPublished - 2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Virology

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