TY - JOUR
T1 - Protective effect of wogonin on endotoxin-induced lethal shock in D-galactosamine-sensitized mice
AU - Van Dien, M.
AU - Takahashi, K.
AU - Mu, M. M.
AU - Koide, N.
AU - Sugiyama, T.
AU - Mori, I.
AU - Yoshida, T.
AU - Yokochi, T.
PY - 2001
Y1 - 2001
N2 - The effects of wogonin, a major flavonoid from Scutellaria baicalensis Georgi, on lipopolysaccharide (LPS)-induced lethal shock in mice was investigated. Wogonin pretreatment prevented the lethal shock in mice injected with D-galactosamine (D-GaIN) and LPS, but not in mice injected with a high dose of LPS. Wogonin definitely inhibited the hepatic injury in mice injected with D-GaIN, and LPS and reduced the level of circulating tumor necrosis factor (TNF)-α. The reduction was more marked in mice injected with D-GaIN and LPS compared with that in mice injected with a high dose of LPS. Wogonin pretreatment did not inhibit the lipid peroxidation in mice receiving either D-GaIN and LPS or a high dose of LPS. Wogonin inhibited the in vitro production of TNF-α and nitric oxide in LPS-stimulated RAW 264.7 cells. The mechanism of the protective effect of wogonin on the lethal shock in mice injected with D-GaIN and LPS is discussed.
AB - The effects of wogonin, a major flavonoid from Scutellaria baicalensis Georgi, on lipopolysaccharide (LPS)-induced lethal shock in mice was investigated. Wogonin pretreatment prevented the lethal shock in mice injected with D-galactosamine (D-GaIN) and LPS, but not in mice injected with a high dose of LPS. Wogonin definitely inhibited the hepatic injury in mice injected with D-GaIN, and LPS and reduced the level of circulating tumor necrosis factor (TNF)-α. The reduction was more marked in mice injected with D-GaIN and LPS compared with that in mice injected with a high dose of LPS. Wogonin pretreatment did not inhibit the lipid peroxidation in mice receiving either D-GaIN and LPS or a high dose of LPS. Wogonin inhibited the in vitro production of TNF-α and nitric oxide in LPS-stimulated RAW 264.7 cells. The mechanism of the protective effect of wogonin on the lethal shock in mice injected with D-GaIN and LPS is discussed.
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U2 - 10.1111/j.1348-0421.2001.tb01311.x
DO - 10.1111/j.1348-0421.2001.tb01311.x
M3 - Article
C2 - 11791668
AN - SCOPUS:0035193063
SN - 0385-5600
VL - 45
SP - 751
EP - 756
JO - MICROBIOLOGY and IMMUNOLOGY
JF - MICROBIOLOGY and IMMUNOLOGY
IS - 11
ER -