Abstract
We examined the neuroprotective role of nicergoline in neuron-microglia or neuron-astrocytes co-cultures. Nicergoline, an ergoline derivative, significantly suppressed the neuronal cell death induced by co-culture with activated microglia or astrocytes stimulated with lipopolysaccharide (LPS) and interferon (IFN)-γ. To elucidate the mechanism by which nicergoline exerts a neuroprotective effect, we examined the production of inflammatory mediators and neurotrophic factors in activated microglia and astrocytes following nicergoline treatment. In microglia stimulated with LPS and IFN-γ, nicergoline suppressed the production of superoxide anions, interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α in a dose-dependent manner. In astrocytes, nicergoline also suppressed the production of proinflammatory cytokines and enhanced brain-derived neurotrophic factor (BDNF). Thus, nicergoline-mediated neuroprotection resulted primarily from the inhibition of inflammatory mediators and the upregulation of neurotrophic factors by glial cells.
Original language | English |
---|---|
Pages (from-to) | 78-85 |
Number of pages | 8 |
Journal | Brain Research |
Volume | 1066 |
Issue number | 1-2 |
DOIs | |
Publication status | Published - 20-12-2005 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- General Neuroscience
- Molecular Biology
- Clinical Neurology
- Developmental Biology