Protein phosphorylation and mechanism of action of tumor-promoting phorbol esters.

U. Kikkawa; K. Kaibuchi; M. Castagna; J. Yamanishi; K. Sano; Y. Tanaka; R. Miyake; Y. Takai; Y. Nishizuka

Protein phosphorylation and mechanism of action of tumor-promoting phorbol esters.

U. Kikkawa, K. Kaibuchi, M. Castagna, J. Yamanishi, K. Sano, Y. Tanaka, R. Miyake, Y. Takai, Y. Nishizuka

Research project for neural and tumor signaling

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

The phorbol ester TPA may be intercalated into the membrane phospholipid bilayer and selectively binds to every molecule of C-kinase in exhibiting its full enzymatic activity. Available evidence suggests that C-kinase is the receptive protein of this tumor promoter, and the results presented seem to provide clues for clarifying the mechanism of controlling cell growth and differentiation.

Original language	English
Pages (from-to)	437-442
Number of pages	6
Journal	Advances in cyclic nucleotide and protein phosphorylation research
Volume	17
Publication status	Published - 1984

All Science Journal Classification (ASJC) codes

General Medicine

Cite this

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title = "Protein phosphorylation and mechanism of action of tumor-promoting phorbol esters.",

abstract = "The phorbol ester TPA may be intercalated into the membrane phospholipid bilayer and selectively binds to every molecule of C-kinase in exhibiting its full enzymatic activity. Available evidence suggests that C-kinase is the receptive protein of this tumor promoter, and the results presented seem to provide clues for clarifying the mechanism of controlling cell growth and differentiation.",

author = "U. Kikkawa and K. Kaibuchi and M. Castagna and J. Yamanishi and K. Sano and Y. Tanaka and R. Miyake and Y. Takai and Y. Nishizuka",

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AU - Kikkawa, U.

AU - Kaibuchi, K.

AU - Castagna, M.

AU - Yamanishi, J.

AU - Sano, K.

AU - Tanaka, Y.

AU - Miyake, R.

AU - Takai, Y.

AU - Nishizuka, Y.

PY - 1984

Y1 - 1984

N2 - The phorbol ester TPA may be intercalated into the membrane phospholipid bilayer and selectively binds to every molecule of C-kinase in exhibiting its full enzymatic activity. Available evidence suggests that C-kinase is the receptive protein of this tumor promoter, and the results presented seem to provide clues for clarifying the mechanism of controlling cell growth and differentiation.

AB - The phorbol ester TPA may be intercalated into the membrane phospholipid bilayer and selectively binds to every molecule of C-kinase in exhibiting its full enzymatic activity. Available evidence suggests that C-kinase is the receptive protein of this tumor promoter, and the results presented seem to provide clues for clarifying the mechanism of controlling cell growth and differentiation.

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AN - SCOPUS:0021314379

SN - 0747-7767

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JO - Advances in cyclic nucleotide and protein phosphorylation research

JF - Advances in cyclic nucleotide and protein phosphorylation research

ER -

Protein phosphorylation and mechanism of action of tumor-promoting phorbol esters.

Abstract

All Science Journal Classification (ASJC) codes

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