Protein phosphorylation and mechanism of action of tumor-promoting phorbol esters.

U. Kikkawa, K. Kaibuchi, M. Castagna, J. Yamanishi, K. Sano, Y. Tanaka, R. Miyake, Y. Takai, Y. Nishizuka

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

The phorbol ester TPA may be intercalated into the membrane phospholipid bilayer and selectively binds to every molecule of C-kinase in exhibiting its full enzymatic activity. Available evidence suggests that C-kinase is the receptive protein of this tumor promoter, and the results presented seem to provide clues for clarifying the mechanism of controlling cell growth and differentiation.

Original languageEnglish
Pages (from-to)437-442
Number of pages6
JournalAdvances in cyclic nucleotide and protein phosphorylation research
Volume17
Publication statusPublished - 01-01-1984

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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