Proton pump inhibitor therapy did not increase the prevalence of small-bowel injury

A propensity-matched analysis

Atsuo Yamada, Ryota Niikura, Koutarou Maki, Masanao Nakamura, Hirotsugu Watabe, Mitsuhiro Fujishiro, Shiro Oka, Shunji Fujimori, Atsushi Nakajima, Naoki Omiya, Takayuki Matsumoto, Shinji Tanaka, Kazuhiko Koike, Choitsu Sakamoto

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Previous studies have reported that the suppression of acid secretion by using proton pump inhibitors (PPIs) results in dysbiosis of the small-bowel microbiota, leading to exacerbated small-bowel injuries, including erosions and ulcers. This study was designed to assess the association between PPI therapy and small-bowel lesions after adjustment for the differences in baseline characteristics between users and non-users of PPIs. Methods: We retrospectively studied patients suspected to be suffering from small-bowel diseases, who underwent capsule endoscopy between 2010 and 2013. We used propensity matching to adjust for the differences in baseline characteristics between users and non-users of PPIs. The outcomes included the prevalence of small-bowel lesions: erosion, ulcer, angioectasia, varices, and tumor. Results: We selected 327 patient pairs for analysis after propensity matching, and found no significant differences in the prevalence of small-bowel injuries, including erosions and ulcers, between users and non-users of PPIs. Two subgroup analyses of the effect of the type of PPI and the effect of PPI therapy in users and non-users of nonsteroidal anti-inflammatory drugs indicated no significant differences in the prevalence of small-bowel injuries in these two groups. Conclusion: PPI therapy did not increase the prevalence of small-bowel injury, regardless of the type of PPI used and the use of nonsteroidal anti-inflammatory drugs.

Original languageEnglish
Article numbere0182586
JournalPloS one
Volume12
Issue number8
DOIs
Publication statusPublished - 01-08-2017

Fingerprint

Proton Pump Inhibitors
therapeutics
Wounds and Injuries
Ulcer
Erosion
Therapeutics
nonsteroidal anti-inflammatory agents
capsule endoscopy
Anti-Inflammatory Agents
Dysbiosis
Capsule Endoscopy
proton pump inhibitors
Endoscopy
Microbiota
Varicose Veins
Pharmaceutical Preparations
Capsules
Tumors
secretion
microorganisms

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Yamada, A., Niikura, R., Maki, K., Nakamura, M., Watabe, H., Fujishiro, M., ... Sakamoto, C. (2017). Proton pump inhibitor therapy did not increase the prevalence of small-bowel injury: A propensity-matched analysis. PloS one, 12(8), [e0182586]. https://doi.org/10.1371/journal.pone.0182586
Yamada, Atsuo ; Niikura, Ryota ; Maki, Koutarou ; Nakamura, Masanao ; Watabe, Hirotsugu ; Fujishiro, Mitsuhiro ; Oka, Shiro ; Fujimori, Shunji ; Nakajima, Atsushi ; Omiya, Naoki ; Matsumoto, Takayuki ; Tanaka, Shinji ; Koike, Kazuhiko ; Sakamoto, Choitsu. / Proton pump inhibitor therapy did not increase the prevalence of small-bowel injury : A propensity-matched analysis. In: PloS one. 2017 ; Vol. 12, No. 8.
@article{19804edfd2fc46f79999c79455385eb2,
title = "Proton pump inhibitor therapy did not increase the prevalence of small-bowel injury: A propensity-matched analysis",
abstract = "Background: Previous studies have reported that the suppression of acid secretion by using proton pump inhibitors (PPIs) results in dysbiosis of the small-bowel microbiota, leading to exacerbated small-bowel injuries, including erosions and ulcers. This study was designed to assess the association between PPI therapy and small-bowel lesions after adjustment for the differences in baseline characteristics between users and non-users of PPIs. Methods: We retrospectively studied patients suspected to be suffering from small-bowel diseases, who underwent capsule endoscopy between 2010 and 2013. We used propensity matching to adjust for the differences in baseline characteristics between users and non-users of PPIs. The outcomes included the prevalence of small-bowel lesions: erosion, ulcer, angioectasia, varices, and tumor. Results: We selected 327 patient pairs for analysis after propensity matching, and found no significant differences in the prevalence of small-bowel injuries, including erosions and ulcers, between users and non-users of PPIs. Two subgroup analyses of the effect of the type of PPI and the effect of PPI therapy in users and non-users of nonsteroidal anti-inflammatory drugs indicated no significant differences in the prevalence of small-bowel injuries in these two groups. Conclusion: PPI therapy did not increase the prevalence of small-bowel injury, regardless of the type of PPI used and the use of nonsteroidal anti-inflammatory drugs.",
author = "Atsuo Yamada and Ryota Niikura and Koutarou Maki and Masanao Nakamura and Hirotsugu Watabe and Mitsuhiro Fujishiro and Shiro Oka and Shunji Fujimori and Atsushi Nakajima and Naoki Omiya and Takayuki Matsumoto and Shinji Tanaka and Kazuhiko Koike and Choitsu Sakamoto",
year = "2017",
month = "8",
day = "1",
doi = "10.1371/journal.pone.0182586",
language = "English",
volume = "12",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "8",

}

Yamada, A, Niikura, R, Maki, K, Nakamura, M, Watabe, H, Fujishiro, M, Oka, S, Fujimori, S, Nakajima, A, Omiya, N, Matsumoto, T, Tanaka, S, Koike, K & Sakamoto, C 2017, 'Proton pump inhibitor therapy did not increase the prevalence of small-bowel injury: A propensity-matched analysis', PloS one, vol. 12, no. 8, e0182586. https://doi.org/10.1371/journal.pone.0182586

Proton pump inhibitor therapy did not increase the prevalence of small-bowel injury : A propensity-matched analysis. / Yamada, Atsuo; Niikura, Ryota; Maki, Koutarou; Nakamura, Masanao; Watabe, Hirotsugu; Fujishiro, Mitsuhiro; Oka, Shiro; Fujimori, Shunji; Nakajima, Atsushi; Omiya, Naoki; Matsumoto, Takayuki; Tanaka, Shinji; Koike, Kazuhiko; Sakamoto, Choitsu.

In: PloS one, Vol. 12, No. 8, e0182586, 01.08.2017.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Proton pump inhibitor therapy did not increase the prevalence of small-bowel injury

T2 - A propensity-matched analysis

AU - Yamada, Atsuo

AU - Niikura, Ryota

AU - Maki, Koutarou

AU - Nakamura, Masanao

AU - Watabe, Hirotsugu

AU - Fujishiro, Mitsuhiro

AU - Oka, Shiro

AU - Fujimori, Shunji

AU - Nakajima, Atsushi

AU - Omiya, Naoki

AU - Matsumoto, Takayuki

AU - Tanaka, Shinji

AU - Koike, Kazuhiko

AU - Sakamoto, Choitsu

PY - 2017/8/1

Y1 - 2017/8/1

N2 - Background: Previous studies have reported that the suppression of acid secretion by using proton pump inhibitors (PPIs) results in dysbiosis of the small-bowel microbiota, leading to exacerbated small-bowel injuries, including erosions and ulcers. This study was designed to assess the association between PPI therapy and small-bowel lesions after adjustment for the differences in baseline characteristics between users and non-users of PPIs. Methods: We retrospectively studied patients suspected to be suffering from small-bowel diseases, who underwent capsule endoscopy between 2010 and 2013. We used propensity matching to adjust for the differences in baseline characteristics between users and non-users of PPIs. The outcomes included the prevalence of small-bowel lesions: erosion, ulcer, angioectasia, varices, and tumor. Results: We selected 327 patient pairs for analysis after propensity matching, and found no significant differences in the prevalence of small-bowel injuries, including erosions and ulcers, between users and non-users of PPIs. Two subgroup analyses of the effect of the type of PPI and the effect of PPI therapy in users and non-users of nonsteroidal anti-inflammatory drugs indicated no significant differences in the prevalence of small-bowel injuries in these two groups. Conclusion: PPI therapy did not increase the prevalence of small-bowel injury, regardless of the type of PPI used and the use of nonsteroidal anti-inflammatory drugs.

AB - Background: Previous studies have reported that the suppression of acid secretion by using proton pump inhibitors (PPIs) results in dysbiosis of the small-bowel microbiota, leading to exacerbated small-bowel injuries, including erosions and ulcers. This study was designed to assess the association between PPI therapy and small-bowel lesions after adjustment for the differences in baseline characteristics between users and non-users of PPIs. Methods: We retrospectively studied patients suspected to be suffering from small-bowel diseases, who underwent capsule endoscopy between 2010 and 2013. We used propensity matching to adjust for the differences in baseline characteristics between users and non-users of PPIs. The outcomes included the prevalence of small-bowel lesions: erosion, ulcer, angioectasia, varices, and tumor. Results: We selected 327 patient pairs for analysis after propensity matching, and found no significant differences in the prevalence of small-bowel injuries, including erosions and ulcers, between users and non-users of PPIs. Two subgroup analyses of the effect of the type of PPI and the effect of PPI therapy in users and non-users of nonsteroidal anti-inflammatory drugs indicated no significant differences in the prevalence of small-bowel injuries in these two groups. Conclusion: PPI therapy did not increase the prevalence of small-bowel injury, regardless of the type of PPI used and the use of nonsteroidal anti-inflammatory drugs.

UR - http://www.scopus.com/inward/record.url?scp=85026848007&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85026848007&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0182586

DO - 10.1371/journal.pone.0182586

M3 - Article

VL - 12

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 8

M1 - e0182586

ER -