Pseudomembranous invasive tracheobronchial aspergillosis with fulminant hepatitis and hemophagocytic syndrome

Suguru Majima, Shotaro Okachi, Motoyo Asano, Keiko Wakahara, Naozumi Hashimoto, Mitsuo Sato, Masatoshi Ishigami, Yoshinori Hasegawa

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Invasive tracheobronchial aspergillosis (ITBA), a rare form of invasive pulmonary Aspergillus infection (IPA), is predominantly confined to the tracheobronchial tree. We herein report a case of ITBA with severe necrotic pseudomembrane in a 57-year-old woman with fulminant hepatitis and hemophagocytic syndrome. Bronchoscopic findings revealed a widespread pseudomembranous formation of the trachea and bronchi. Aspergillus fumigatus was cultured from bronchial lavage fluid, and the histological findings of an endobronchial biopsy revealed necrosis and invasive hyphae. Although she responded to antifungal treatment, she ultimately died of a septic shock with Burkholderia cepacia 57 days after admission.

Original languageEnglish
Pages (from-to)2371-2375
Number of pages5
JournalInternal Medicine
Volume57
Issue number16
DOIs
Publication statusPublished - 2018
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Internal Medicine

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