Pseudomyxoma peritonei accompanied by intraductal papillary mucinous neoplasm of the pancreas

Yohei Mizuta, Yuko Akazawa, Ken Shiozawa, Hiroshi Ohara, Kazuo Ohba, Ken Ohnita, Hajime Isomoto, Fuminao Takeshima, Katsuhisa Omagari, Kenji Tanaka, Tohru Yasutake, Tohru Nakagoe, Kenji Shirono, Shigeru Kohno

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

We describe a case of pseudomyxoma peritonei (PMP) successfully managed with intraperitoneal hyperthermic chemoperfusion. This case is unique due to the concurrent presence of intraductal papillary mucinous neoplasm (IPMN) of the pancreas. The patient presented with abdominal fullness. Abdominal computed tomography revealed massive ascites, thickened peritoneum, and a cystic lesion of the pancreas. Cytological examination of ascitic fluid sample showed mucin-rich atypical cells. Endoscopic retrograde pancreatography revealed a cystic lesion with the defect probably due to mural nodule and mucin, communicating with the pancreatic duct. At exploratory laparotomy, massive ascites and multiple nodules were identified within the peritoneal cavity. No primary tumour, including mucinous neoplasm of the appendix, was found. Histopathological examination of the omentum showed mucinous adenocarcinoma in pools of mucoid material, consistent with PMP. The relation between PMP and IPMN of the pancreas was possible, but not conclusive. The patient received intraperitoneal perfusion of saline heated to 42°C containing cisplatin, etoposide, and mitomycin C, followed by 24 courses of postoperative chemotherapy with gemcitabine. The patient remains in good general condition with no signs of progression of PMP for 2 years, but with a gradual and progressive enlargement of the pancreatic cystic lesion.

Original languageEnglish
Pages (from-to)470-474
Number of pages5
JournalPancreatology
Volume5
Issue number4-5
DOIs
Publication statusPublished - 01-01-2005

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Pseudomyxoma Peritonei
Pancreatic Neoplasms
Mucins
gemcitabine
Ascites
Mucinous Adenocarcinoma
Omentum
Pancreatic Ducts
Ascitic Fluid
Peritoneum
Peritoneal Cavity
Appendix
Mitomycin
Etoposide
Laparotomy
Cisplatin
Pancreas
Neoplasms
Perfusion
Tomography

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Gastroenterology

Cite this

Mizuta, Y., Akazawa, Y., Shiozawa, K., Ohara, H., Ohba, K., Ohnita, K., ... Kohno, S. (2005). Pseudomyxoma peritonei accompanied by intraductal papillary mucinous neoplasm of the pancreas. Pancreatology, 5(4-5), 470-474. https://doi.org/10.1159/000086551
Mizuta, Yohei ; Akazawa, Yuko ; Shiozawa, Ken ; Ohara, Hiroshi ; Ohba, Kazuo ; Ohnita, Ken ; Isomoto, Hajime ; Takeshima, Fuminao ; Omagari, Katsuhisa ; Tanaka, Kenji ; Yasutake, Tohru ; Nakagoe, Tohru ; Shirono, Kenji ; Kohno, Shigeru. / Pseudomyxoma peritonei accompanied by intraductal papillary mucinous neoplasm of the pancreas. In: Pancreatology. 2005 ; Vol. 5, No. 4-5. pp. 470-474.
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abstract = "We describe a case of pseudomyxoma peritonei (PMP) successfully managed with intraperitoneal hyperthermic chemoperfusion. This case is unique due to the concurrent presence of intraductal papillary mucinous neoplasm (IPMN) of the pancreas. The patient presented with abdominal fullness. Abdominal computed tomography revealed massive ascites, thickened peritoneum, and a cystic lesion of the pancreas. Cytological examination of ascitic fluid sample showed mucin-rich atypical cells. Endoscopic retrograde pancreatography revealed a cystic lesion with the defect probably due to mural nodule and mucin, communicating with the pancreatic duct. At exploratory laparotomy, massive ascites and multiple nodules were identified within the peritoneal cavity. No primary tumour, including mucinous neoplasm of the appendix, was found. Histopathological examination of the omentum showed mucinous adenocarcinoma in pools of mucoid material, consistent with PMP. The relation between PMP and IPMN of the pancreas was possible, but not conclusive. The patient received intraperitoneal perfusion of saline heated to 42°C containing cisplatin, etoposide, and mitomycin C, followed by 24 courses of postoperative chemotherapy with gemcitabine. The patient remains in good general condition with no signs of progression of PMP for 2 years, but with a gradual and progressive enlargement of the pancreatic cystic lesion.",
author = "Yohei Mizuta and Yuko Akazawa and Ken Shiozawa and Hiroshi Ohara and Kazuo Ohba and Ken Ohnita and Hajime Isomoto and Fuminao Takeshima and Katsuhisa Omagari and Kenji Tanaka and Tohru Yasutake and Tohru Nakagoe and Kenji Shirono and Shigeru Kohno",
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Mizuta, Y, Akazawa, Y, Shiozawa, K, Ohara, H, Ohba, K, Ohnita, K, Isomoto, H, Takeshima, F, Omagari, K, Tanaka, K, Yasutake, T, Nakagoe, T, Shirono, K & Kohno, S 2005, 'Pseudomyxoma peritonei accompanied by intraductal papillary mucinous neoplasm of the pancreas', Pancreatology, vol. 5, no. 4-5, pp. 470-474. https://doi.org/10.1159/000086551

Pseudomyxoma peritonei accompanied by intraductal papillary mucinous neoplasm of the pancreas. / Mizuta, Yohei; Akazawa, Yuko; Shiozawa, Ken; Ohara, Hiroshi; Ohba, Kazuo; Ohnita, Ken; Isomoto, Hajime; Takeshima, Fuminao; Omagari, Katsuhisa; Tanaka, Kenji; Yasutake, Tohru; Nakagoe, Tohru; Shirono, Kenji; Kohno, Shigeru.

In: Pancreatology, Vol. 5, No. 4-5, 01.01.2005, p. 470-474.

Research output: Contribution to journalArticle

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T1 - Pseudomyxoma peritonei accompanied by intraductal papillary mucinous neoplasm of the pancreas

AU - Mizuta, Yohei

AU - Akazawa, Yuko

AU - Shiozawa, Ken

AU - Ohara, Hiroshi

AU - Ohba, Kazuo

AU - Ohnita, Ken

AU - Isomoto, Hajime

AU - Takeshima, Fuminao

AU - Omagari, Katsuhisa

AU - Tanaka, Kenji

AU - Yasutake, Tohru

AU - Nakagoe, Tohru

AU - Shirono, Kenji

AU - Kohno, Shigeru

PY - 2005/1/1

Y1 - 2005/1/1

N2 - We describe a case of pseudomyxoma peritonei (PMP) successfully managed with intraperitoneal hyperthermic chemoperfusion. This case is unique due to the concurrent presence of intraductal papillary mucinous neoplasm (IPMN) of the pancreas. The patient presented with abdominal fullness. Abdominal computed tomography revealed massive ascites, thickened peritoneum, and a cystic lesion of the pancreas. Cytological examination of ascitic fluid sample showed mucin-rich atypical cells. Endoscopic retrograde pancreatography revealed a cystic lesion with the defect probably due to mural nodule and mucin, communicating with the pancreatic duct. At exploratory laparotomy, massive ascites and multiple nodules were identified within the peritoneal cavity. No primary tumour, including mucinous neoplasm of the appendix, was found. Histopathological examination of the omentum showed mucinous adenocarcinoma in pools of mucoid material, consistent with PMP. The relation between PMP and IPMN of the pancreas was possible, but not conclusive. The patient received intraperitoneal perfusion of saline heated to 42°C containing cisplatin, etoposide, and mitomycin C, followed by 24 courses of postoperative chemotherapy with gemcitabine. The patient remains in good general condition with no signs of progression of PMP for 2 years, but with a gradual and progressive enlargement of the pancreatic cystic lesion.

AB - We describe a case of pseudomyxoma peritonei (PMP) successfully managed with intraperitoneal hyperthermic chemoperfusion. This case is unique due to the concurrent presence of intraductal papillary mucinous neoplasm (IPMN) of the pancreas. The patient presented with abdominal fullness. Abdominal computed tomography revealed massive ascites, thickened peritoneum, and a cystic lesion of the pancreas. Cytological examination of ascitic fluid sample showed mucin-rich atypical cells. Endoscopic retrograde pancreatography revealed a cystic lesion with the defect probably due to mural nodule and mucin, communicating with the pancreatic duct. At exploratory laparotomy, massive ascites and multiple nodules were identified within the peritoneal cavity. No primary tumour, including mucinous neoplasm of the appendix, was found. Histopathological examination of the omentum showed mucinous adenocarcinoma in pools of mucoid material, consistent with PMP. The relation between PMP and IPMN of the pancreas was possible, but not conclusive. The patient received intraperitoneal perfusion of saline heated to 42°C containing cisplatin, etoposide, and mitomycin C, followed by 24 courses of postoperative chemotherapy with gemcitabine. The patient remains in good general condition with no signs of progression of PMP for 2 years, but with a gradual and progressive enlargement of the pancreatic cystic lesion.

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