Pseudoprogression successfully treated with bevacizumab in a child with spinal pilocytic astrocytoma

Kenji Miyata; Toshinori Hori; Yasuto Shimomura; Masahiro Joko; Masakazu Takayasu; Akihisa Okumura

doi:10.1007/s00381-018-3841-7

Pseudoprogression successfully treated with bevacizumab in a child with spinal pilocytic astrocytoma

Kenji Miyata, Toshinori Hori, Yasuto Shimomura, Masahiro Joko, Masakazu Takayasu, Akihisa Okumura

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Clinical case: We report on a 7-year-old female with spinal pilocytic astrocytoma complicated by pseudoprogression 1 month after completion of radiation therapy. Although she was initially treated with high-dose steroids, her clinical symptoms did not completely resolve, and magnetic resonance imaging (MRI) revealed extension of the lesions into the medulla oblongata. Treatment with bevacizumab was commenced, followed by rapid resolution of the clinical symptoms and improvements in the MRI findings. Conclusion: This case highlights the efficacy and tolerability of bevacizumab for the treatment of pseudoprogression in children with spinal low-grade gliomas.

Original language	English
Pages (from-to)	2305-2308
Number of pages	4
Journal	Child's Nervous System
Volume	34
Issue number	11
DOIs	https://doi.org/10.1007/s00381-018-3841-7
Publication status	Published - 01-11-2018
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pediatrics, Perinatology, and Child Health
Clinical Neurology

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10.1007/s00381-018-3841-7

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title = "Pseudoprogression successfully treated with bevacizumab in a child with spinal pilocytic astrocytoma",

abstract = "Clinical case: We report on a 7-year-old female with spinal pilocytic astrocytoma complicated by pseudoprogression 1 month after completion of radiation therapy. Although she was initially treated with high-dose steroids, her clinical symptoms did not completely resolve, and magnetic resonance imaging (MRI) revealed extension of the lesions into the medulla oblongata. Treatment with bevacizumab was commenced, followed by rapid resolution of the clinical symptoms and improvements in the MRI findings. Conclusion: This case highlights the efficacy and tolerability of bevacizumab for the treatment of pseudoprogression in children with spinal low-grade gliomas.",

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AU - Miyata, Kenji

AU - Hori, Toshinori

AU - Shimomura, Yasuto

AU - Joko, Masahiro

AU - Takayasu, Masakazu

AU - Okumura, Akihisa

PY - 2018/11/1

Y1 - 2018/11/1

N2 - Clinical case: We report on a 7-year-old female with spinal pilocytic astrocytoma complicated by pseudoprogression 1 month after completion of radiation therapy. Although she was initially treated with high-dose steroids, her clinical symptoms did not completely resolve, and magnetic resonance imaging (MRI) revealed extension of the lesions into the medulla oblongata. Treatment with bevacizumab was commenced, followed by rapid resolution of the clinical symptoms and improvements in the MRI findings. Conclusion: This case highlights the efficacy and tolerability of bevacizumab for the treatment of pseudoprogression in children with spinal low-grade gliomas.

AB - Clinical case: We report on a 7-year-old female with spinal pilocytic astrocytoma complicated by pseudoprogression 1 month after completion of radiation therapy. Although she was initially treated with high-dose steroids, her clinical symptoms did not completely resolve, and magnetic resonance imaging (MRI) revealed extension of the lesions into the medulla oblongata. Treatment with bevacizumab was commenced, followed by rapid resolution of the clinical symptoms and improvements in the MRI findings. Conclusion: This case highlights the efficacy and tolerability of bevacizumab for the treatment of pseudoprogression in children with spinal low-grade gliomas.

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Pseudoprogression successfully treated with bevacizumab in a child with spinal pilocytic astrocytoma

Abstract

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