PTPRD gene associated with blood pressure response to atenolol and resistant hypertension

Yan Gong, Caitrin W. McDonough, Amber L. Beitelshees, Nihal El Rouby, Timo P. Hiltunen, Jeffrey R. O'Connell, Sandosh Padmanabhan, Taimour Y. Langaee, Karen Hall, Siegfried O.F. Schmidt, Robert W. Curry, John G. Gums, Kati M. Donner, Kimmo K. Kontula, Kent R. Bailey, Eric Boerwinkle, Atsushi Takahashi, Toshihiro Tanaka, Michiaki Kubo, Arlene B. ChapmanStephen T. Turner, Carl J. Pepine, Rhonda M. Cooper-DeHoff, Julie A. Johnson

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Objective: The aim of this study is to identify singlenucleotide polymorphisms (SNPs) influencing blood pressure (BP) response to the b-blocker atenolol. Methods: Genome-wide association analysis of BP response to atenolol monotherapy was performed in 233 white participants with uncomplicated hypertension in the pharmacogenomic evaluation of antihypertensive responses study. Forty-two polymorphisms with P less than 10-5 for association with either diastolic or systolic response to atenolol monotherapy were validated in four independent groups of hypertensive individuals (total n=2114). Results: In whites, two polymorphisms near the gene PTPRD (rs12346562 and rs1104514) were associated with DBP response to atenolol (P=3.2.10-6 and P=5.9.10-6, respectively) with directionally opposite association for response to hydrochlorothiazide in another group of 228 whites (P=0.0018 and P=0.00012). A different polymorphism (rs10739150) near PTPRD was associated with response to atenolol in 150 black hypertensive individuals (P=8.2510-6). rs12346562 had a similar trend in association with response to bisoprolol (a different b-blocker) in 207 Finnish men in the genetics of drug responsiveness in essential hypertension study. In addition, an intronic single-nucleotide polymorphism (rs4742610) in the PTPRD gene was associated with resistant hypertension in whites and Hispanics in the international verapamil SR trandolapril study (meta-analysis P=3.210-5). Conclusion: PTPRD was identified as a novel locus potentially associated with BP response to atenolol and resistant hypertension in multiple ethnic groups.

Original languageEnglish
Pages (from-to)2278-2285
Number of pages8
JournalJournal of Hypertension
Volume33
Issue number11
DOIs
Publication statusPublished - 01-01-2015

Fingerprint

Atenolol
Blood Pressure
Hypertension
Genes
trandolapril
Bisoprolol
Hydrochlorothiazide
Genome-Wide Association Study
Pharmacogenetics
Verapamil
Hispanic Americans
Ethnic Groups
Antihypertensive Agents
Single Nucleotide Polymorphism
Meta-Analysis
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Gong, Y., McDonough, C. W., Beitelshees, A. L., Rouby, N. E., Hiltunen, T. P., O'Connell, J. R., ... Johnson, J. A. (2015). PTPRD gene associated with blood pressure response to atenolol and resistant hypertension. Journal of Hypertension, 33(11), 2278-2285. https://doi.org/10.1097/HJH.0000000000000714
Gong, Yan ; McDonough, Caitrin W. ; Beitelshees, Amber L. ; Rouby, Nihal El ; Hiltunen, Timo P. ; O'Connell, Jeffrey R. ; Padmanabhan, Sandosh ; Langaee, Taimour Y. ; Hall, Karen ; Schmidt, Siegfried O.F. ; Curry, Robert W. ; Gums, John G. ; Donner, Kati M. ; Kontula, Kimmo K. ; Bailey, Kent R. ; Boerwinkle, Eric ; Takahashi, Atsushi ; Tanaka, Toshihiro ; Kubo, Michiaki ; Chapman, Arlene B. ; Turner, Stephen T. ; Pepine, Carl J. ; Cooper-DeHoff, Rhonda M. ; Johnson, Julie A. / PTPRD gene associated with blood pressure response to atenolol and resistant hypertension. In: Journal of Hypertension. 2015 ; Vol. 33, No. 11. pp. 2278-2285.
@article{6971478f50174f418b82f235c1b9fe4b,
title = "PTPRD gene associated with blood pressure response to atenolol and resistant hypertension",
abstract = "Objective: The aim of this study is to identify singlenucleotide polymorphisms (SNPs) influencing blood pressure (BP) response to the b-blocker atenolol. Methods: Genome-wide association analysis of BP response to atenolol monotherapy was performed in 233 white participants with uncomplicated hypertension in the pharmacogenomic evaluation of antihypertensive responses study. Forty-two polymorphisms with P less than 10-5 for association with either diastolic or systolic response to atenolol monotherapy were validated in four independent groups of hypertensive individuals (total n=2114). Results: In whites, two polymorphisms near the gene PTPRD (rs12346562 and rs1104514) were associated with DBP response to atenolol (P=3.2.10-6 and P=5.9.10-6, respectively) with directionally opposite association for response to hydrochlorothiazide in another group of 228 whites (P=0.0018 and P=0.00012). A different polymorphism (rs10739150) near PTPRD was associated with response to atenolol in 150 black hypertensive individuals (P=8.2510-6). rs12346562 had a similar trend in association with response to bisoprolol (a different b-blocker) in 207 Finnish men in the genetics of drug responsiveness in essential hypertension study. In addition, an intronic single-nucleotide polymorphism (rs4742610) in the PTPRD gene was associated with resistant hypertension in whites and Hispanics in the international verapamil SR trandolapril study (meta-analysis P=3.210-5). Conclusion: PTPRD was identified as a novel locus potentially associated with BP response to atenolol and resistant hypertension in multiple ethnic groups.",
author = "Yan Gong and McDonough, {Caitrin W.} and Beitelshees, {Amber L.} and Rouby, {Nihal El} and Hiltunen, {Timo P.} and O'Connell, {Jeffrey R.} and Sandosh Padmanabhan and Langaee, {Taimour Y.} and Karen Hall and Schmidt, {Siegfried O.F.} and Curry, {Robert W.} and Gums, {John G.} and Donner, {Kati M.} and Kontula, {Kimmo K.} and Bailey, {Kent R.} and Eric Boerwinkle and Atsushi Takahashi and Toshihiro Tanaka and Michiaki Kubo and Chapman, {Arlene B.} and Turner, {Stephen T.} and Pepine, {Carl J.} and Cooper-DeHoff, {Rhonda M.} and Johnson, {Julie A.}",
year = "2015",
month = "1",
day = "1",
doi = "10.1097/HJH.0000000000000714",
language = "English",
volume = "33",
pages = "2278--2285",
journal = "Journal of Hypertension",
issn = "0263-6352",
publisher = "Lippincott Williams and Wilkins",
number = "11",

}

Gong, Y, McDonough, CW, Beitelshees, AL, Rouby, NE, Hiltunen, TP, O'Connell, JR, Padmanabhan, S, Langaee, TY, Hall, K, Schmidt, SOF, Curry, RW, Gums, JG, Donner, KM, Kontula, KK, Bailey, KR, Boerwinkle, E, Takahashi, A, Tanaka, T, Kubo, M, Chapman, AB, Turner, ST, Pepine, CJ, Cooper-DeHoff, RM & Johnson, JA 2015, 'PTPRD gene associated with blood pressure response to atenolol and resistant hypertension', Journal of Hypertension, vol. 33, no. 11, pp. 2278-2285. https://doi.org/10.1097/HJH.0000000000000714

PTPRD gene associated with blood pressure response to atenolol and resistant hypertension. / Gong, Yan; McDonough, Caitrin W.; Beitelshees, Amber L.; Rouby, Nihal El; Hiltunen, Timo P.; O'Connell, Jeffrey R.; Padmanabhan, Sandosh; Langaee, Taimour Y.; Hall, Karen; Schmidt, Siegfried O.F.; Curry, Robert W.; Gums, John G.; Donner, Kati M.; Kontula, Kimmo K.; Bailey, Kent R.; Boerwinkle, Eric; Takahashi, Atsushi; Tanaka, Toshihiro; Kubo, Michiaki; Chapman, Arlene B.; Turner, Stephen T.; Pepine, Carl J.; Cooper-DeHoff, Rhonda M.; Johnson, Julie A.

In: Journal of Hypertension, Vol. 33, No. 11, 01.01.2015, p. 2278-2285.

Research output: Contribution to journalArticle

TY - JOUR

T1 - PTPRD gene associated with blood pressure response to atenolol and resistant hypertension

AU - Gong, Yan

AU - McDonough, Caitrin W.

AU - Beitelshees, Amber L.

AU - Rouby, Nihal El

AU - Hiltunen, Timo P.

AU - O'Connell, Jeffrey R.

AU - Padmanabhan, Sandosh

AU - Langaee, Taimour Y.

AU - Hall, Karen

AU - Schmidt, Siegfried O.F.

AU - Curry, Robert W.

AU - Gums, John G.

AU - Donner, Kati M.

AU - Kontula, Kimmo K.

AU - Bailey, Kent R.

AU - Boerwinkle, Eric

AU - Takahashi, Atsushi

AU - Tanaka, Toshihiro

AU - Kubo, Michiaki

AU - Chapman, Arlene B.

AU - Turner, Stephen T.

AU - Pepine, Carl J.

AU - Cooper-DeHoff, Rhonda M.

AU - Johnson, Julie A.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Objective: The aim of this study is to identify singlenucleotide polymorphisms (SNPs) influencing blood pressure (BP) response to the b-blocker atenolol. Methods: Genome-wide association analysis of BP response to atenolol monotherapy was performed in 233 white participants with uncomplicated hypertension in the pharmacogenomic evaluation of antihypertensive responses study. Forty-two polymorphisms with P less than 10-5 for association with either diastolic or systolic response to atenolol monotherapy were validated in four independent groups of hypertensive individuals (total n=2114). Results: In whites, two polymorphisms near the gene PTPRD (rs12346562 and rs1104514) were associated with DBP response to atenolol (P=3.2.10-6 and P=5.9.10-6, respectively) with directionally opposite association for response to hydrochlorothiazide in another group of 228 whites (P=0.0018 and P=0.00012). A different polymorphism (rs10739150) near PTPRD was associated with response to atenolol in 150 black hypertensive individuals (P=8.2510-6). rs12346562 had a similar trend in association with response to bisoprolol (a different b-blocker) in 207 Finnish men in the genetics of drug responsiveness in essential hypertension study. In addition, an intronic single-nucleotide polymorphism (rs4742610) in the PTPRD gene was associated with resistant hypertension in whites and Hispanics in the international verapamil SR trandolapril study (meta-analysis P=3.210-5). Conclusion: PTPRD was identified as a novel locus potentially associated with BP response to atenolol and resistant hypertension in multiple ethnic groups.

AB - Objective: The aim of this study is to identify singlenucleotide polymorphisms (SNPs) influencing blood pressure (BP) response to the b-blocker atenolol. Methods: Genome-wide association analysis of BP response to atenolol monotherapy was performed in 233 white participants with uncomplicated hypertension in the pharmacogenomic evaluation of antihypertensive responses study. Forty-two polymorphisms with P less than 10-5 for association with either diastolic or systolic response to atenolol monotherapy were validated in four independent groups of hypertensive individuals (total n=2114). Results: In whites, two polymorphisms near the gene PTPRD (rs12346562 and rs1104514) were associated with DBP response to atenolol (P=3.2.10-6 and P=5.9.10-6, respectively) with directionally opposite association for response to hydrochlorothiazide in another group of 228 whites (P=0.0018 and P=0.00012). A different polymorphism (rs10739150) near PTPRD was associated with response to atenolol in 150 black hypertensive individuals (P=8.2510-6). rs12346562 had a similar trend in association with response to bisoprolol (a different b-blocker) in 207 Finnish men in the genetics of drug responsiveness in essential hypertension study. In addition, an intronic single-nucleotide polymorphism (rs4742610) in the PTPRD gene was associated with resistant hypertension in whites and Hispanics in the international verapamil SR trandolapril study (meta-analysis P=3.210-5). Conclusion: PTPRD was identified as a novel locus potentially associated with BP response to atenolol and resistant hypertension in multiple ethnic groups.

UR - http://www.scopus.com/inward/record.url?scp=84943159217&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84943159217&partnerID=8YFLogxK

U2 - 10.1097/HJH.0000000000000714

DO - 10.1097/HJH.0000000000000714

M3 - Article

C2 - 26425837

AN - SCOPUS:84943159217

VL - 33

SP - 2278

EP - 2285

JO - Journal of Hypertension

JF - Journal of Hypertension

SN - 0263-6352

IS - 11

ER -

Gong Y, McDonough CW, Beitelshees AL, Rouby NE, Hiltunen TP, O'Connell JR et al. PTPRD gene associated with blood pressure response to atenolol and resistant hypertension. Journal of Hypertension. 2015 Jan 1;33(11):2278-2285. https://doi.org/10.1097/HJH.0000000000000714