Pulmonary infectious complications associated with anti-TNFα therapy (infliximab) for rheumatoid arthritis

Kazuyoshi Imaizumi, Mihoko Sugishita, Miho Usui, Tsutomu Kawabe, Naozumi Hashimoto, Yoshinori Hasegawa

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23 Citations (Scopus)


Two patients with rheumatoid arthritis (RA) that developed serious infectious complications following anti-TNFα therapy (infliximab) are reported. Patient 1 developed tuberculosis with high fever, refractory diarrhea and mediastinal lymphadenopathy. Trans-bronchial needle biopsy was useful to confirm the diagnosis. Patient 2 showed sudden onset of dyspnea with diffuse bilateral lung infiltration caused by pneumocystis jiroveci pneumonia and the diagnosis was confirmed by broncho-alveolar lavage. Physicians should be alerted to infectious complications with atypical presentation and rapid progression in infliximab-treated patients. Invasive diagnostic procedures including fiber-optic bronchoscopy may be necessary early in the course for such cases.

Original languageEnglish
Pages (from-to)685-688
Number of pages4
JournalInternal Medicine
Issue number10
Publication statusPublished - 15-06-2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Internal Medicine


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