Pulmonary infectious complications associated with anti-TNFα therapy (infliximab) for rheumatoid arthritis

Kazuyoshi Imaizumi; Mihoko Sugishita; Miho Usui; Tsutomu Kawabe; Naozumi Hashimoto; Yoshinori Hasegawa

doi:10.2169/internalmedicine.45.1623

Pulmonary infectious complications associated with anti-TNFα therapy (infliximab) for rheumatoid arthritis

Kazuyoshi Imaizumi, Mihoko Sugishita, Miho Usui, Tsutomu Kawabe, Naozumi Hashimoto, Yoshinori Hasegawa

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Two patients with rheumatoid arthritis (RA) that developed serious infectious complications following anti-TNFα therapy (infliximab) are reported. Patient 1 developed tuberculosis with high fever, refractory diarrhea and mediastinal lymphadenopathy. Trans-bronchial needle biopsy was useful to confirm the diagnosis. Patient 2 showed sudden onset of dyspnea with diffuse bilateral lung infiltration caused by pneumocystis jiroveci pneumonia and the diagnosis was confirmed by broncho-alveolar lavage. Physicians should be alerted to infectious complications with atypical presentation and rapid progression in infliximab-treated patients. Invasive diagnostic procedures including fiber-optic bronchoscopy may be necessary early in the course for such cases.

Original language	English
Pages (from-to)	685-688
Number of pages	4
Journal	Internal Medicine
Volume	45
Issue number	10
DOIs	https://doi.org/10.2169/internalmedicine.45.1623
Publication status	Published - 15-06-2006
Externally published	Yes

All Science Journal Classification (ASJC) codes

Internal Medicine

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2169/internalmedicine.45.1623

Cite this

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title = "Pulmonary infectious complications associated with anti-TNFα therapy (infliximab) for rheumatoid arthritis",

abstract = "Two patients with rheumatoid arthritis (RA) that developed serious infectious complications following anti-TNFα therapy (infliximab) are reported. Patient 1 developed tuberculosis with high fever, refractory diarrhea and mediastinal lymphadenopathy. Trans-bronchial needle biopsy was useful to confirm the diagnosis. Patient 2 showed sudden onset of dyspnea with diffuse bilateral lung infiltration caused by pneumocystis jiroveci pneumonia and the diagnosis was confirmed by broncho-alveolar lavage. Physicians should be alerted to infectious complications with atypical presentation and rapid progression in infliximab-treated patients. Invasive diagnostic procedures including fiber-optic bronchoscopy may be necessary early in the course for such cases.",

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AU - Imaizumi, Kazuyoshi

AU - Sugishita, Mihoko

AU - Usui, Miho

AU - Kawabe, Tsutomu

AU - Hashimoto, Naozumi

AU - Hasegawa, Yoshinori

PY - 2006/6/15

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AB - Two patients with rheumatoid arthritis (RA) that developed serious infectious complications following anti-TNFα therapy (infliximab) are reported. Patient 1 developed tuberculosis with high fever, refractory diarrhea and mediastinal lymphadenopathy. Trans-bronchial needle biopsy was useful to confirm the diagnosis. Patient 2 showed sudden onset of dyspnea with diffuse bilateral lung infiltration caused by pneumocystis jiroveci pneumonia and the diagnosis was confirmed by broncho-alveolar lavage. Physicians should be alerted to infectious complications with atypical presentation and rapid progression in infliximab-treated patients. Invasive diagnostic procedures including fiber-optic bronchoscopy may be necessary early in the course for such cases.

KW - Anti-TNFα therapy

KW - Fiber-optic bronchoscopy

KW - Infliximab

KW - Pneumocystis jiroveci (carinii) pneumonia

KW - Rheumatoid arthritis

KW - Tuberculosis

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Pulmonary infectious complications associated with anti-TNFα therapy (infliximab) for rheumatoid arthritis

Abstract

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