TY - JOUR
T1 - Pulmonary MR imaging with ultra-short TEs
T2 - Utility for disease severity assessment of connective tissue disease patients
AU - Ohno, Yoshiharu
AU - Nishio, Mizuho
AU - Koyama, Hisanobu
AU - Takenaka, Daisuke
AU - Takahashi, Masaya
AU - Yoshikawa, Takeshi
AU - Matsumoto, Sumiaki
AU - Obara, Makoto
AU - Van Cauteren, Marc
AU - Sugimura, Kazuro
N1 - Funding Information:
The authors wish to thank Yoshiyuki Ohno, MD, PhD, M.P.H., Professor Emeritus, Nagoya University (Department of Preventive Medicine, Graduate School of Medicine), Kazuyuki Kobayashi, MD, PhD, Yasuhiro Funada, MD, PhD, Tetuari Onishi, MD, Yoshikazu Kotani, MD, PhD, and Yoshihiro Nishimura, MD, PhD (Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine), and Shin-ichi Kumagai, MD, PhD, Professor Emeritus, Kobe University Graduate School of Medicine (Department of Laboratory Medicine, Kobe University Graduate School of Medicine) for their contributions to this study. This work was supported Philips Healthcare Philips Electronics Japan, and Smoking Research Foundation .
PY - 2013/8
Y1 - 2013/8
N2 - Purpose To evaluate the utility of pulmonary magnetic resonance (MR) imaging with ultra-short echo times (UTEs) at a 3.0 T MR system for pulmonary functional loss and disease severity assessments of connective tissue disease (CTD) patients with interstitial lung disease (ILD). Materials and methods This prospective study was approved by the institutional review board, and written informed consent was obtained from 18 CTD patients (eight men and ten women) and eight normal subjects with suspected chest disease (three men and five women). All subjects underwent thin-section MDCT, pulmonary MR imaging with UTEs, pulmonary function test and serum KL-6. Regional T2* maps were generated from each MR data set, and mean T2* values were determined from ROI measurements. From each thin-section MDCT data set, CT-based disease severity was evaluated with a visual scoring system. Mean T2* values for normal and CTD subjects were statistically compared by using Student's t-test. To assess capability for pulmonary functional loss and disease severity assessments, mean T2* values were statistically correlated with pulmonary functional parameters, serum KL-6 and CT-based disease severity. Results Mean T2* values for normal and CTD subjects were significantly different (p = 0.0019) and showed significant correlations with %VC, %DLCO, serum KL-6 and CT-based disease severity of CTD patients (p < 0.05). Conclusion Pulmonary MR imaging with UTEs is useful for pulmonary functional loss and disease severity assessments of CTD patients with ILD.
AB - Purpose To evaluate the utility of pulmonary magnetic resonance (MR) imaging with ultra-short echo times (UTEs) at a 3.0 T MR system for pulmonary functional loss and disease severity assessments of connective tissue disease (CTD) patients with interstitial lung disease (ILD). Materials and methods This prospective study was approved by the institutional review board, and written informed consent was obtained from 18 CTD patients (eight men and ten women) and eight normal subjects with suspected chest disease (three men and five women). All subjects underwent thin-section MDCT, pulmonary MR imaging with UTEs, pulmonary function test and serum KL-6. Regional T2* maps were generated from each MR data set, and mean T2* values were determined from ROI measurements. From each thin-section MDCT data set, CT-based disease severity was evaluated with a visual scoring system. Mean T2* values for normal and CTD subjects were statistically compared by using Student's t-test. To assess capability for pulmonary functional loss and disease severity assessments, mean T2* values were statistically correlated with pulmonary functional parameters, serum KL-6 and CT-based disease severity. Results Mean T2* values for normal and CTD subjects were significantly different (p = 0.0019) and showed significant correlations with %VC, %DLCO, serum KL-6 and CT-based disease severity of CTD patients (p < 0.05). Conclusion Pulmonary MR imaging with UTEs is useful for pulmonary functional loss and disease severity assessments of CTD patients with ILD.
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U2 - 10.1016/j.ejrad.2013.02.031
DO - 10.1016/j.ejrad.2013.02.031
M3 - Article
C2 - 23523024
AN - SCOPUS:84879507162
SN - 0720-048X
VL - 82
SP - 1359
EP - 1365
JO - European journal of radiology
JF - European journal of radiology
IS - 8
ER -