TY - JOUR
T1 - Pulmonary symptoms measured by the national institutes of health lung score predict overall survival, nonrelapse mortality, and patient-reported outcomes in chronic graft-versus-host disease
AU - Palmer, Jeanne
AU - Williams, Kirsten
AU - Inamoto, Yoshihiro
AU - Chai, Xiaoyu
AU - Martin, Paul J.
AU - Tomas, Linus Santo
AU - Cutler, Corey
AU - Weisdorf, Daniel
AU - Kurland, Brenda F.
AU - Carpenter, Paul A.
AU - Pidala, Joseph
AU - Pavletic, Steven Z.
AU - Wood, William
AU - Jacobsohn, David
AU - Arai, Sally
AU - Arora, Mukta
AU - Jagasia, Madan
AU - Vogelsang, Georgia B.
AU - Lee, Stephanie J.
PY - 2014/3
Y1 - 2014/3
N2 - The 2005 National Institutes of Health (NIH) Consensus Conference recommended assessment of lung function in patients with chronic graft-versus-host disease (GVHD) by both pulmonary function tests (PFTs) and assessment of pulmonary symptoms. We tested whether pulmonary measures were associated with nonrelapse mortality (NRM), overall survival (OS), and patient-reported outcomes (PRO). Clinician and patient-reported data were collected serially in a prospective, multicenter, observational study. Available PFT data were abstracted. Cox regression models were fit for outcomes using a time-varying covariate model for lung function measures and adjusting for patient and transplantation characteristics and nonlung chronic GVHD severity. A total of 1591 visits (496 patients) were used in this analysis. The NIH symptom-based lung score was associated with NRM (P= .02), OS (P= .02), patient-reported symptoms (P < .001) and functional status (P < .001). Worsening of NIH symptom-based lung score over time was associated with higher NRM and lower survival. All other measures were not associated with OS or NRM; although, some were associated with patient-reported lung symptoms. In conclusion, the NIH symptom-based lung symptom score of 0 to 3 is associated with NRM, OS, and PRO measures in patients with chronic GVHD. Worsening of the NIH symptom-based lung score was associated with increased mortality.
AB - The 2005 National Institutes of Health (NIH) Consensus Conference recommended assessment of lung function in patients with chronic graft-versus-host disease (GVHD) by both pulmonary function tests (PFTs) and assessment of pulmonary symptoms. We tested whether pulmonary measures were associated with nonrelapse mortality (NRM), overall survival (OS), and patient-reported outcomes (PRO). Clinician and patient-reported data were collected serially in a prospective, multicenter, observational study. Available PFT data were abstracted. Cox regression models were fit for outcomes using a time-varying covariate model for lung function measures and adjusting for patient and transplantation characteristics and nonlung chronic GVHD severity. A total of 1591 visits (496 patients) were used in this analysis. The NIH symptom-based lung score was associated with NRM (P= .02), OS (P= .02), patient-reported symptoms (P < .001) and functional status (P < .001). Worsening of NIH symptom-based lung score over time was associated with higher NRM and lower survival. All other measures were not associated with OS or NRM; although, some were associated with patient-reported lung symptoms. In conclusion, the NIH symptom-based lung symptom score of 0 to 3 is associated with NRM, OS, and PRO measures in patients with chronic GVHD. Worsening of the NIH symptom-based lung score was associated with increased mortality.
UR - https://www.scopus.com/pages/publications/84896815699
UR - https://www.scopus.com/pages/publications/84896815699#tab=citedBy
U2 - 10.1016/j.bbmt.2013.11.025
DO - 10.1016/j.bbmt.2013.11.025
M3 - Article
C2 - 24315845
AN - SCOPUS:84896815699
SN - 1083-8791
VL - 20
SP - 337
EP - 344
JO - Biology of Blood and Marrow Transplantation
JF - Biology of Blood and Marrow Transplantation
IS - 3
ER -