QT interval prolongation and the risks of stroke and coronary heart disease in a general Japanese population

The Hisayama study

Daisuke Maebuchi, Hisatomi Arima, Yasufumi Doi, Toshiharu Ninomiya, Koji Yonemoto, Yumihiro Tanizaki, Michiaki Kubo, Jun Hata, Kiyoshi Matsumura, Mitsuo Iida, Yutaka Kiyohara

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Uncertainty remains regarding the value of heart-rate-corrected QT interval (QTc) prolongation on electrocardiogram for predicting cardiovascular disease (CVD), particularly among Asian populations. The objective of the present analysis was to analyze the association of QTc prolongation with the development of CVD in a general Japanese population. During the follow-up period, 303 CVD events were observed. Among men, the age-adjusted incidence rates of CVD rose with prolonged QTc levels: 10.9, 12.1, 14.1 and 37.8 per 1000 person-years for subgroups defined by QTc levels of < 400, 400-419, 420-439 and ≤ 440 ms, respectively (P0.0007 for trend). The risk of CVD in the highest group was 3.09-fold (95% confidence interval, 1.82-5.25) higher than that in the lowest group even after controlling for other confounding factors: age, hypertension, heart rate, electrocardiogram abnormalities, diabetes, impaired glucose tolerance, impaired fasting glycemia, body mass index, total and high-density lipoprotein cholesterols, alcohol intake, smoking habit and regular exercise. Similar associations were observed for the outcomes of stroke and coronary heart disease. Among women, in contrast, no clear associations were found between QTc levels and the risk of CVD events. In conclusion, prolonged QTc levels were associated with the development of CVD among general Japanese men. Measurement of QTc intervals is likely to provide additional information for the detection of individuals at high risk of future CVD events.

Original languageEnglish
Pages (from-to)916-921
Number of pages6
JournalHypertension Research
Volume33
Issue number9
DOIs
Publication statusPublished - 01-09-2010

Fingerprint

Coronary Disease
Cardiovascular Diseases
Stroke
Population
Electrocardiography
Heart Rate
Glucose Intolerance
Age Factors
HDL Cholesterol
Uncertainty
Habits
Fasting
Body Mass Index
Smoking
Alcohols
Confidence Intervals
Exercise
Hypertension
Incidence

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Maebuchi, Daisuke ; Arima, Hisatomi ; Doi, Yasufumi ; Ninomiya, Toshiharu ; Yonemoto, Koji ; Tanizaki, Yumihiro ; Kubo, Michiaki ; Hata, Jun ; Matsumura, Kiyoshi ; Iida, Mitsuo ; Kiyohara, Yutaka. / QT interval prolongation and the risks of stroke and coronary heart disease in a general Japanese population : The Hisayama study. In: Hypertension Research. 2010 ; Vol. 33, No. 9. pp. 916-921.
@article{cebc4361a90a443fa2d91a122b5eb6c7,
title = "QT interval prolongation and the risks of stroke and coronary heart disease in a general Japanese population: The Hisayama study",
abstract = "Uncertainty remains regarding the value of heart-rate-corrected QT interval (QTc) prolongation on electrocardiogram for predicting cardiovascular disease (CVD), particularly among Asian populations. The objective of the present analysis was to analyze the association of QTc prolongation with the development of CVD in a general Japanese population. During the follow-up period, 303 CVD events were observed. Among men, the age-adjusted incidence rates of CVD rose with prolonged QTc levels: 10.9, 12.1, 14.1 and 37.8 per 1000 person-years for subgroups defined by QTc levels of < 400, 400-419, 420-439 and ≤ 440 ms, respectively (P0.0007 for trend). The risk of CVD in the highest group was 3.09-fold (95{\%} confidence interval, 1.82-5.25) higher than that in the lowest group even after controlling for other confounding factors: age, hypertension, heart rate, electrocardiogram abnormalities, diabetes, impaired glucose tolerance, impaired fasting glycemia, body mass index, total and high-density lipoprotein cholesterols, alcohol intake, smoking habit and regular exercise. Similar associations were observed for the outcomes of stroke and coronary heart disease. Among women, in contrast, no clear associations were found between QTc levels and the risk of CVD events. In conclusion, prolonged QTc levels were associated with the development of CVD among general Japanese men. Measurement of QTc intervals is likely to provide additional information for the detection of individuals at high risk of future CVD events.",
author = "Daisuke Maebuchi and Hisatomi Arima and Yasufumi Doi and Toshiharu Ninomiya and Koji Yonemoto and Yumihiro Tanizaki and Michiaki Kubo and Jun Hata and Kiyoshi Matsumura and Mitsuo Iida and Yutaka Kiyohara",
year = "2010",
month = "9",
day = "1",
doi = "10.1038/hr.2010.88",
language = "English",
volume = "33",
pages = "916--921",
journal = "Hypertension Research",
issn = "0916-9636",
publisher = "Nature Publishing Group",
number = "9",

}

Maebuchi, D, Arima, H, Doi, Y, Ninomiya, T, Yonemoto, K, Tanizaki, Y, Kubo, M, Hata, J, Matsumura, K, Iida, M & Kiyohara, Y 2010, 'QT interval prolongation and the risks of stroke and coronary heart disease in a general Japanese population: The Hisayama study', Hypertension Research, vol. 33, no. 9, pp. 916-921. https://doi.org/10.1038/hr.2010.88

QT interval prolongation and the risks of stroke and coronary heart disease in a general Japanese population : The Hisayama study. / Maebuchi, Daisuke; Arima, Hisatomi; Doi, Yasufumi; Ninomiya, Toshiharu; Yonemoto, Koji; Tanizaki, Yumihiro; Kubo, Michiaki; Hata, Jun; Matsumura, Kiyoshi; Iida, Mitsuo; Kiyohara, Yutaka.

In: Hypertension Research, Vol. 33, No. 9, 01.09.2010, p. 916-921.

Research output: Contribution to journalArticle

TY - JOUR

T1 - QT interval prolongation and the risks of stroke and coronary heart disease in a general Japanese population

T2 - The Hisayama study

AU - Maebuchi, Daisuke

AU - Arima, Hisatomi

AU - Doi, Yasufumi

AU - Ninomiya, Toshiharu

AU - Yonemoto, Koji

AU - Tanizaki, Yumihiro

AU - Kubo, Michiaki

AU - Hata, Jun

AU - Matsumura, Kiyoshi

AU - Iida, Mitsuo

AU - Kiyohara, Yutaka

PY - 2010/9/1

Y1 - 2010/9/1

N2 - Uncertainty remains regarding the value of heart-rate-corrected QT interval (QTc) prolongation on electrocardiogram for predicting cardiovascular disease (CVD), particularly among Asian populations. The objective of the present analysis was to analyze the association of QTc prolongation with the development of CVD in a general Japanese population. During the follow-up period, 303 CVD events were observed. Among men, the age-adjusted incidence rates of CVD rose with prolonged QTc levels: 10.9, 12.1, 14.1 and 37.8 per 1000 person-years for subgroups defined by QTc levels of < 400, 400-419, 420-439 and ≤ 440 ms, respectively (P0.0007 for trend). The risk of CVD in the highest group was 3.09-fold (95% confidence interval, 1.82-5.25) higher than that in the lowest group even after controlling for other confounding factors: age, hypertension, heart rate, electrocardiogram abnormalities, diabetes, impaired glucose tolerance, impaired fasting glycemia, body mass index, total and high-density lipoprotein cholesterols, alcohol intake, smoking habit and regular exercise. Similar associations were observed for the outcomes of stroke and coronary heart disease. Among women, in contrast, no clear associations were found between QTc levels and the risk of CVD events. In conclusion, prolonged QTc levels were associated with the development of CVD among general Japanese men. Measurement of QTc intervals is likely to provide additional information for the detection of individuals at high risk of future CVD events.

AB - Uncertainty remains regarding the value of heart-rate-corrected QT interval (QTc) prolongation on electrocardiogram for predicting cardiovascular disease (CVD), particularly among Asian populations. The objective of the present analysis was to analyze the association of QTc prolongation with the development of CVD in a general Japanese population. During the follow-up period, 303 CVD events were observed. Among men, the age-adjusted incidence rates of CVD rose with prolonged QTc levels: 10.9, 12.1, 14.1 and 37.8 per 1000 person-years for subgroups defined by QTc levels of < 400, 400-419, 420-439 and ≤ 440 ms, respectively (P0.0007 for trend). The risk of CVD in the highest group was 3.09-fold (95% confidence interval, 1.82-5.25) higher than that in the lowest group even after controlling for other confounding factors: age, hypertension, heart rate, electrocardiogram abnormalities, diabetes, impaired glucose tolerance, impaired fasting glycemia, body mass index, total and high-density lipoprotein cholesterols, alcohol intake, smoking habit and regular exercise. Similar associations were observed for the outcomes of stroke and coronary heart disease. Among women, in contrast, no clear associations were found between QTc levels and the risk of CVD events. In conclusion, prolonged QTc levels were associated with the development of CVD among general Japanese men. Measurement of QTc intervals is likely to provide additional information for the detection of individuals at high risk of future CVD events.

UR - http://www.scopus.com/inward/record.url?scp=77956412080&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77956412080&partnerID=8YFLogxK

U2 - 10.1038/hr.2010.88

DO - 10.1038/hr.2010.88

M3 - Article

VL - 33

SP - 916

EP - 921

JO - Hypertension Research

JF - Hypertension Research

SN - 0916-9636

IS - 9

ER -