Quantification of anthranilic acid and its related enzyme activity in several different species

S. Fujigaki, K. Saito, H. Fujii, H. Wada, M. Seishima

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Anthranilic acid (AA) has been attracted considerable attention as one of the L-tryptophan-kynurenine pathway metabolites in the central nervous system. In this study, the concentration of L-kynurenine (L-KYN) and AA in serum and CSF, and its related enzyme activities were determined in several species. In rabbits, CSF AA concentrations were lower and serum AA concentrations were slightly higher than those in other species. However, the concentrations of L-KYN were substantially higher in rabbits in both serum and CSF compared with other species. Tissue enzyme activities varied among species. In rabbits, lung IDO activities were higher, but liver kynurenine 3-hydroxylase activities were lower than those of the other species tested. Furthermore, brain kynurenine 3-hydroxylase activities were higher in gerbils than those in other species. These results clearly demonstrated that kynurenine pathway enzyme activities and metabolite concentrations vary with species.

Original languageEnglish
Pages (from-to)625-628
Number of pages4
JournalAdvances in Experimental Medicine and Biology
Volume467
Publication statusPublished - 01-12-2000
Externally publishedYes

Fingerprint

Kynurenine
Enzyme activity
Kynurenine 3-Monooxygenase
Enzymes
Metabolites
Rabbits
Serum
Gerbillinae
Neurology
Tryptophan
Liver
Brain
Central Nervous System
Tissue
Lung
anthranilic acid

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

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Quantification of anthranilic acid and its related enzyme activity in several different species. / Fujigaki, S.; Saito, K.; Fujii, H.; Wada, H.; Seishima, M.

In: Advances in Experimental Medicine and Biology, Vol. 467, 01.12.2000, p. 625-628.

Research output: Contribution to journalArticle

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AU - Fujigaki, S.

AU - Saito, K.

AU - Fujii, H.

AU - Wada, H.

AU - Seishima, M.

PY - 2000/12/1

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