Quantification of myocardial blood flow using the combination of bolus tracking and time-registered helical multidetector CT angiography during adenosine stress

Takashi Ichihara, Richard T. George, Richard Mather, Caterina Silva, Joao A.C. Lima, Albert C. Lardo

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

The purpose of this study was to develop a quantitative method for myocardial blood flow (MBF) measurement that can be used to derive accurate myocardial perfusion measurements from contrast-enhanced multidetector computed tomography (MDCT) images with bolus tracking and helical scanning. Nine canine models of left anterior descending artery (LAD) stenosis were prepared and underwent MDCT perfusion imaging during adenosine infusion (0.14-0.21 mg/kg/min) to study a wide range of flows. Neutron-activated microspheres were injected to document MBF during adenosine infusion. Six animals underwent dynamic MDCT perfusion imaging, and K1 and k2, which represent the first-order transfer constants from left ventricular blood to myocardium and from myocardium to the vascular system, respectively, were measured using a compartment model. The results were compared against microsphere MBF measurements, and the extraction fraction (E) of contrast agent and the mean value of K1/k2 were calculated. Six animals then underwent helical MDCT perfusion imaging during adenosine infusion. Prior to discontinuation of the

Original languageEnglish
Title of host publicationIEEE Nuclear Science Symposuim and Medical Imaging Conference, NSS/MIC 2010
Pages2573-2577
Number of pages5
DOIs
Publication statusPublished - 01-12-2010
Event2010 IEEE Nuclear Science Symposium, Medical Imaging Conference, NSS/MIC 2010 and 17th International Workshop on Room-Temperature Semiconductor X-ray and Gamma-ray Detectors, RTSD 2010 - Knoxville, TN, United States
Duration: 30-10-201006-11-2010

Publication series

NameIEEE Nuclear Science Symposium Conference Record
ISSN (Print)1095-7863

Conference

Conference2010 IEEE Nuclear Science Symposium, Medical Imaging Conference, NSS/MIC 2010 and 17th International Workshop on Room-Temperature Semiconductor X-ray and Gamma-ray Detectors, RTSD 2010
CountryUnited States
CityKnoxville, TN
Period30-10-1006-11-10

All Science Journal Classification (ASJC) codes

  • Radiation
  • Nuclear and High Energy Physics
  • Radiology Nuclear Medicine and imaging

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    Ichihara, T., George, R. T., Mather, R., Silva, C., Lima, J. A. C., & Lardo, A. C. (2010). Quantification of myocardial blood flow using the combination of bolus tracking and time-registered helical multidetector CT angiography during adenosine stress. In IEEE Nuclear Science Symposuim and Medical Imaging Conference, NSS/MIC 2010 (pp. 2573-2577). [5874252] (IEEE Nuclear Science Symposium Conference Record). https://doi.org/10.1109/NSSMIC.2010.5874252