Quantitative analysis of first-pass contrast-enhanced myocardial perfusion MRI using a Patlak plot method and blood saturation correction

Takashi Ichihara, Masaki Ishida, Kakuya Kitagawa, Yasutaka Ichikawa, Takahiro Natsume, Noriyasu Yamaki, Hisato Maeda, Kan Takeda, Hajime Sakuma

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)

Abstract

The objectives of this study were to develop a method for quantifying myocardial K1 and blood flow (MBF) with minimal operator interaction by using a Patlak plot method and to compare the MBF obtained by perfusion MRI with that from coronary sinus blood flow in the resting state. A method that can correct for the nonlinearity of the blood time-signal intensity curve on perfusion MR images was developed. Myocardial perfusion MR images were acquired with a saturation-recovery balanced turbo field-echo sequence in 10 patients. Coronary sinus blood flow was determined by phase-contrast cine MRI, and the average MBF was calculated as coronary sinus blood flow divided by left ventricular (LV) mass obtained by cine MRI. Patlak plot analysis was performed using the saturation-corrected blood time-signal intensity curve as an input function and the regional myocardial time-signal intensity curve as an output function. The mean MBF obtained by perfusion MRI was 86 ± 25 ml/min/100 g, showing good agreement with MBF calculated from coronary sinus blood flow (89 ± 30 ml/min/100 g, r = 0.74). The mean coefficient of variation for measuring regional MBF in 16 LV myocardial segments was 0.11. The current method using Patlak plot permits quantification of MBF with operator interaction limited to tracing the LV wall contours, registration, and time delays.

Original languageEnglish
Pages (from-to)373-383
Number of pages11
JournalMagnetic Resonance in Medicine
Volume62
Issue number2
DOIs
Publication statusPublished - 08-2009

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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